Exertional heat stroke and susceptibility to malignant hyperthermia in an athlete: Evidence for a link?

Journal of Athletic Training

Volumn 50, Issue 11, 2015, Pages 1212-1214

  Poussel, Mathias ^a   Guerci, Philippe ^a   Kaminsky, Pierre ^a   Heymonet, Marie ^a   Roux Buisson, Nathalie ^b   Faure, Julien ^b   Fronzaroli, Emilien ^a   Chenuel, Bruno ^a  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Exertional rhabdomyolysis; Heat illness; RYR1 gene; Thermoregulation

Indexed keywords

RYANODINE RECEPTOR;

ADULT; CASE REPORT; EXERCISE; EXERCISE TEST; FOOTBALL; GENETIC PREDISPOSITION; GENETICS; HEAT STROKE; HUMAN; MALE; MALIGNANT HYPERTHERMIA; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RHABDOMYOLYSIS; RUNNING; SEIZURE;

ADULT; EXERCISE TEST; FOOTBALL; GENETIC PREDISPOSITION TO DISEASE; HEAT STROKE; HUMANS; MALE; MALIGNANT HYPERTHERMIA; MUTATION; PHYSICAL EXERTION; RHABDOMYOLYSIS; RUNNING; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SEIZURES;

EID: 84949226001     PISSN: 10626050     EISSN: None     Source Type: Journal    
DOI: 10.4085/1062-6050-50.12.01     Document Type: Article

References (13)

1. Casa DJ, Armstrong LE, Kenny GP, O'Connor FG, Huggins RA. Exertional heat stroke: new concepts regarding cause and care. Curr Sports Med Rep. 2012;11(3):115-123.
2. Grogan H, Hopkins PM. Heat stroke: implications for critical care and anaesthesia. Br J Anaesth. 2002;88(5):700-707.
3. Capacchione JF, Muldoon SM. The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia. Anesth Analg. 2009;109(4):1065-1069.
4. Riazi S, Kraeva N, Muldoon SM, et al. Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference. Can J Anaesth. 2014;61(11):1040-1049.
5. Tobin JR, Jason DR, Challa VR, Nelson TE, Sambuughin N. Malignant hyperthermia and apparent heat stroke. JAMA. 2001; 286(2):168-169.
6. Wappler F, Fiege M, Steinfath M, et al. Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdo-myolysis. Anesthesiology. 2001;94(1):95-100.
7. Carsana A. Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyper-thermia susceptibility, and RYR1 gene sequence variations. Sci World J. 2013;531465.
8. Vukcevic M, Broman M, Islander G, et al. Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease. Anesth Analg. 2010;111(1): 185-190.
9. Dlamini N, Voermans NC, Lillis S, et al. Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis. Neuro-muscul Disord. 2013;23(7):540-548.
10. Vanuxem P, Vanuxem D, Raharison L, Aubert M, Pouliquen G, Deslangles O. Maximal exercise and muscle energy metabolism after recovery from exercise hyperthermia syndrome. Muscle Nerve. 2001; 24(8):1071-1077.
11. Campbell IT, Ellis FR, Evans RT, Mortimer MG. Studies of body temperatures, blood lactate, cortisol and free fatty acid levels during exercise in human subjects susceptible to malignant hyperpyrexia. Acta Anaesthesiol Scand. 1983;27(5):349-355.
12. Armstrong LE, Casa DJ, Millard-Stafford M, et al. American College of Sports Medicine position stand: exertional heat illness during training and competition. Med Sci Sports Exerc. 2007;39(3):556-572.
13. Hopkins PM. Is there a link between malignant hyperthermia and exertional heat illness? Br J Sports Med. 2007;41(5):283-284.