Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking

Social Neuroscience

Volumn 11, Issue 5, 2016, Pages 487-494

  Chester, David S ^a   DeWall, C Nathan ^a   Derefinko, Karen J ^b   Estus, Steven ^c   Lynam, Donald R ^d   Peters, Jessica R ^a,e   Jiang, Yang ^c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d PURDUE UNIVERSITY   (United States)

^e BROWN UNIVERSITY   (United States)

Author keywords

aggression; Dopamine; DRD2; reward; sensation seeking

Indexed keywords

DOPAMINE 2 RECEPTOR; DRD2 PROTEIN, HUMAN;

AGGRESSION; BIOLOGICAL MODEL; CAUCASIAN; EXECUTIVE FUNCTION; FEMALE; GENETICS; GENOTYPING TECHNIQUE; HUMAN; MALE; PSYCHOLOGIC TEST; PSYCHOLOGICAL MODEL; REWARD; SINGLE NUCLEOTIDE POLYMORPHISM;

AGGRESSION; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXECUTIVE FUNCTION; FEMALE; GENOTYPING TECHNIQUES; HUMANS; MALE; MODELS, GENETIC; MODELS, PSYCHOLOGICAL; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOLOGICAL TESTS; RECEPTORS, DOPAMINE D2; REWARD;

EID: 84949206522     PISSN: 17470919     EISSN: 17470927     Source Type: Journal    
DOI: 10.1080/17470919.2015.1119191     Document Type: Article

References (48)

1. R.D.Baler, & N.D.Volkow, (2006). Drug addiction:The neurobiology of disrupted self-control. Trends in Molecular Medicine, 12(12), 559–566. doi:10.1016/j.molmed.2006.10.005
2. J.C.Barnes, B.B.Boutwell, K.M.Beaver, C.L.Gibson, & J.P.Wright, (2014). On the consequences of ignoring genetic influences in criminological research. Journal of Criminal Justice, 42(6), 471–482. doi:10.1016/j.jcrimjus.2014.08.003
3. K.M.Beaver, E.J.Connolly, J.A.Schwartz, M.S.Al-Ghamdi, & A.N.Kobeisy, (2013). Genetic and environmental contributions to stability and change in levels of self-control. Journal of Criminal Justice, 41(5), 300–308. doi:10.1016/j.jcrimjus.2013.07.003
4. K.M.Beaver, C.L.Gibson, M.DeLisi, M.G.Vaughn, & J.P.Wright, (2012). The interaction between neighborhood disadvantage and genetic factors in the prediction of antisocial outcomes. Youth Violence and Juvenile Justice, 10(1), 25–40. doi:10.1177/1541204011422085
5. L.Berkowitz, (1989). Affective aggression:The role of stress, pain, and negative affect. In R.G.Geen & E.Donnerstein (Eds.), Human aggression:Theories, research, and implications for social policy (pp. 49–72). San Diego, CA:Academic Press.
6. K.Blum, P.J.Sheridan, R.C.Wood, E.R.Braverman, T.J.H.Chen, J.G.Cull, & D.E.Comings, (1996). The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. Journal of the Royal Society of Medicine, 89(7), 396–400.
7. B.J.Bushman, R.F.Baumeister, & C.M.Phillips, (2001). Do people aggress to improve their mood? Catharsis beliefs, affect regulation opportunity, and aggressive responding. Journal of Personality and Social Psychology, 81(1), 17–32. doi:10.1037/0022-3514.81.1.17
8. D.S.Chester, & C.N.DeWall, (in press). The pleasure of revenge:Retaliatory aggression arises from a neural imbalance towards reward. Social Cognitive and Affective Neuroscience. Advance online publication. doi:10.1093/scan/nsv082
9. D.S.Chester, C.N.DeWall, K.J.Derefinko, S.Estus, J.R.Peters, D.R.Lynam, & Y.Jiang, (2015). Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect. Behavioural Brain Research, 283, 97–101. doi:10.1016/j.bbr.2015.01.034
10. D.E.Comings, & K.Blum, (2000). Reward deficiency syndrome:Genetic aspects of behavioral disorders. In G.G.Van E., J.P.C.De Bruin, M.G.P.Feenstra, C.M.A.Pennartz, & H.B.M.Uylings (Eds.), Progress in brain research (Vol. 126, pp. 325–341). Philadelphia, PA:Elsevier.
11. D.E.Comings, L.Ferry, S.Bradshaw-Robinson, R.Burchette, C.Chiu, & D.Muhleman, (1996). The dopamine D2 receptor (DRD2) gene:A genetic risk factor in smoking. Pharmacogenetics, 6(1), 73–79. doi:10.1097/00008571-199602000-00006
12. M.H.Couppis, & C.H.Kennedy, (2008). The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice. Psychopharmacology, 197(3), 449–456. doi:10.1007/s00213-007-1054-y
13. C.Davis, & N.J.Loxton, (2013). Addictive behaviors and addiction-prone personality traits:Associations with a dopamine multilocus genetic profile. Addictive Behaviors, 38(7), 2306–2312. doi:10.1016/j.addbeh.2013.02.012
14. M.DeLisi, K.M.Beaver, M.G.Vaughn, & J.P.Wright, (2009). All in the family:Gene  environment interaction between DRD2 and criminal father is associated with five antisocial phenotypes. Criminal Justice and Behavior, 36(11), 1187–1197. doi:10.1177/0093854809342884
15. M.DeLisi, & M.G.Vaughn, (2014). Foundation for a temperament-based theory of antisocial behavior and criminal justice system involvement. Journal of Criminal Justice, 42(1), 10–25. doi:10.1016/j.jcrimjus.2013.11.001
16. T.F.Denson, C.N.DeWall, & E.J.Finkel, (2012). Self-control and aggression. Current Directions in Psychological Science, 21(1), 20–25. doi:10.1177/0963721411429451
17. K.J.Derefinko, C.N.DeWall, A.V.Metze, E.C.Walsh, & D.R.Lynam, (2011). Do different facets of impulsivity predict different types of aggression? Aggressive Behavior, 37(3), 223–233. doi:10.1002/ab.v37.3
18. C.Esposito-Smythers, A.Spirito, C.Rizzo, J.E.McGeary, & V.S.Knopik, (2009). Associations of the DRD2 TaqIA polymorphism with impulsivity and substance use:Preliminary results from a clinical sample of adolescents. Pharmacology Biochemistry and Behavior, 93(3), 306–312. doi:10.1016/j.pbb.2009.03.012
19. E.J.Finkel, (2013). The I3 model:Metatheory, theory, and evidence. Advances in Experimental Social Psychology, 49, 1.
20. M.R.Gottfredson, & T.Hirschi, (1990). A general theory of crime (Vol. xvi). Stanford, CA:Stanford University Press.
21. G.Guo, M.E.Roettger, & J.C.Shih, (2007). Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Human Genetics, 121(1), 125–136. doi:10.1007/s00439-006-0244-8
22. G.Guo, & Y.Tong, (2006). Age at first sexual intercourse, genes, and social context:Evidence from twins and the dopamine D4 receptor gene. Demography, 43(4), 747–769. doi:10.1353/dem.2006.0029
23. C.Helmstaedter, Y.Mihov, M.R.Toliat, H.Thiele, P.Nuernberg, S.Schoch, … R.Hurlemann, (2013). Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia, 54(1), 36–44. doi:10.1111/j.1528-1167.2012.03603.x
24. S.Ikemoto, (2007). Dopamine reward circuitry:Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex. Brain Research Reviews, 56(1), 27–78. doi:10.1016/j.brainresrev.2007.05.004
25. J.Joireman, J.Anderson, & A.Strathman, (2003). The aggression paradox:Understanding links among aggression, sensation seeking, and the consideration of future consequences. Journal of Personality and Social Psychology, 84(6), 1287–1302. doi:10.1037/0022-3514.84.6.1287
26. K.Kasiakogia-Worlley, A.McQuillin, G.J.Lydall, S.Patel, G.Kottalgi, P.Gunwardena, & H.M.D.Gurling, (2011). Lack of allelic association between markers at the DRD2 and ANKK1 gene loci with the alcohol-dependence syndrome and criminal activity. Psychiatric Genetics, 21(6), 323–324. doi:10.1097/YPG.0b013e3283458a68
27. U.M.Krämer, H.Jansma, C.Tempelmann, & T.F.Münte, (2007). Tit-for-tat:The neural basis of reactive aggression. NeuroImage, 38(1), 203–211. doi:10.1016/j.neuroimage.2007.07.029
28. D.R.Lynam, G.T.Smith, S.P.Whiteside, & M.A.Cyders, (2006). The UPPS-P:Assessing five personality pathways to impulsive behavior (Technical Report). West Lafayette, IN:Purdue University.
29. D.R.Lynam, S.Whiteside, & S.Jones, (1999). Self-reported psychopathy:A validation study. Journal of Personality Assessment, 73(1), 110–132. doi:10.1207/S15327752JPA730108
30. M.McKay, & P.D.Rogers, (2000). The anger control workbook. Oakland, CA:New Harbinger Publications.
31. D.R.Miles, & G.Carey, (1997). Genetic and environmental architecture on human aggression. Journal of Personality and Social Psychology, 72(1), 207–217. doi:10.1037/0022-3514.72.1.207
32. Z.Nemoda, K.Lyons-Ruth, A.Szekely, E.Bertha, G.Faludi, & M.Sasvari-Szekely, (2010). Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behavioral and Brain Functions, 6, 4. doi:10.1186/1744-9081-6-4
33. E.P.Noble, K.Blum, T.Ritchie, A.Montgomery, & P.J.Sheridan, (1991). Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism or gene ism. Archives of General Psychiatry, 48(7), 648–654. doi:10.1001/archpsyc.1991.01810310066012
34. M.Peciña, B.J.Mickey, T.Love, H.Wang, S.A.Langenecker, C.Hodgkinson, … J.-K.Zubieta, (2013). DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex, 49(3), 877–890. doi:10.1016/j.cortex.2012.01.010
35. M.I.Posner, M.K.Rothbart, B.E.Sheese, & Y.Tang, (2007). The anterior cingulate gyrus and the mechanism of self-regulation. Cognitive, Affective, & Behavioral Neuroscience, 7(4), 391–395. doi:10.3758/CABN.7.4.391
36. K.J.Preacher, & A.F.Hayes, (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40(3), 879–891. doi:10.3758/BRM.40.3.879
37. A.Raine, (2008). From genes to brain to antisocial behavior. Current Directions in Psychological Science, 17(5), 323–328. doi:10.1111/cdir.2008.17.issue-5
38. J.M.Ramírez, M.-C.Bonniot-Cabanac, & M.Cabanac, (2005). Can aggression provide pleasure? European Psychologist, 10(2), 136–145. doi:10.1027/1016-9040.10.2.136
39. P.Rocca, L.Marchiaro, E.Cocuzza, & F.Bogetto, (2002). Treatment of borderline personality disorder with risperidone. The Journal of Clinical Psychiatry, 63(3), 241–244. doi:10.4088/JCP.v63n0311
40. R.M.Rodriguiz, R.Chu, M.G.Caron, & W.C.Wetsel, (2004). Aberrant responses in social interaction of dopamine transporter knockout mice. Behavioural Brain Research, 148(1–2), 185–198. doi:10.1016/S0166-4328(03)00187-6
41. D.Seo, C.J.Patrick, & P.J.Kennealy, (2008). Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders. Aggression and Violent Behavior, 13(5), 383–395. doi:10.1016/j.avb.2008.06.003
42. J.P.Tangney, R.F.Baumeister, & A.L.Boone, (2004). High self-control predicts good adjustment, less pathology, better grades, and interpersonal success. Journal of Personality, 72(2), 271–324. doi:10.1111/j.0022-3506.2004.00263.x
43. J.Vaske, J.P.Wright, & K.M.Beaver, (2011). A dopamine gene (DRD2) distinguishes between offenders who have and have not been violently victimized. International Journal of Offender Therapy and Comparative Criminology, 55(2), 251–267. doi:10.1177/0306624X10361583
44. S.P.Whiteside, & D.R.Lynam, (2001). The five factor model and impulsivity:Using a structural model of personality to understand impulsivity. Personality and Individual Differences, 30(4), 669–689. doi:10.1016/S0191-8869(00)00064-7
45. S.P.Whiteside, D.R.Lynam, J.D.Miller, & S.K.Reynolds, (2005). Validation of the UPPS impulsive behaviour scale:A four-factor model of impulsivity. European Journal of Personality, 19(7), 559–574. doi:10.1002/(ISSN)1099-0984
46. T.Wu, & J.C.Barnes, (2013). Two dopamine receptor genes (DRD2 and DRD4) predict psychopathic personality traits in a sample of American adults. Journal of Criminal Justice, 41(3), 188–195. doi:10.1016/j.jcrimjus.2013.02.001
47. J.R.Yancey, N.C.Venables, B.M.Hicks, & C.J.Patrick, (2013). Evidence for a heritable brain basis to deviance-promoting deficits in self-control. Journal of Criminal Justice, 41(5), 309–317. doi:10.1016/j.jcrimjus.2013.06.002
48. C.C.Zai, S.Ehtesham, E.Choi, B.Nowrouzi, V.De Luca, L.Stankovich, … J.H.Beitchman, (2012). Dopaminergic system genes in childhood aggression:Possible role for DRD2. The World Journal of Biological Psychiatry, 13(1), 65–74. doi:10.3109/15622975.2010.543431