Cardiorespiratory and sensory responses to exercise in adults with mild cystic fibrosis

Journal of Applied Physiology

Volumn 119, Issue 11, 2015, Pages 1289-1296

  Quon, Bradley S ^a,b   Wilkie, Sabrina S ^b   Molgat Seon, Yannick ^b,c   Schaeffer, Michele R ^b   Ramsook, Andrew H ^b   Wilcox, Pearce G ^a,b   Guenette, Jordan A ^b  

^a Ellis Hall   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c School of Kinesiology   (Canada)

Author keywords

Dynamic hyperinflation; Dyspnea; Exercise limitation; Expiratory flow limitation; Ventilatory responses

Indexed keywords

ADULT; ANAEROBIC THRESHOLD; BREATHING MECHANICS; COHORT ANALYSIS; COMPLICATION; CYSTIC FIBROSIS; EXERCISE; EXERCISE TEST; FEMALE; FITNESS; FORCED EXPIRATORY VOLUME; HEMODYNAMICS; HUMAN; LUNG DISEASE; LUNG VOLUME; MALE; PATHOPHYSIOLOGY; SENSATION; TIDAL VOLUME;

ADULT; ANAEROBIC THRESHOLD; COHORT STUDIES; CYSTIC FIBROSIS; EXERCISE; EXERCISE TEST; FEMALE; FORCED EXPIRATORY VOLUME; HEMODYNAMICS; HUMANS; LUNG DISEASES; LUNG VOLUME MEASUREMENTS; MALE; PHYSICAL FITNESS; RESPIRATORY MECHANICS; SENSATION; TIDAL VOLUME;

EID: 84949191365     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00692.2015     Document Type: Article

References (45)

1. American Thoracic Society, European Respiratory Society. ATS/ERS statement on respiratory muscle testing. Am J Respir Crit Care Med 166: 518-624, 2002.
2. American Thoracic Society, American College of Chest Physicians. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 167: 211-277, 2003.
3. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985) 60: 2020-2027, 1986.
4. Borel B, Leclair E, Thevenet D, Beghin L, Gottrand F, Fabre C. Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children. Pediatr Pulmonol 49: 221-229, 2014.
5. Chin RC, Guenette JA, Cheng S, Raghavan N, Amornputtisathaporn N, Cortes-Telles A, Webb KA, O'Donnell DE. Does the respiratory system limit exercise in mild chronic obstructive pulmonary disease? Am J Respir Crit Care Med 187: 1315-1323, 2013.
6. Coates AL, Boyce P, Muller D, Mearns M, Godfrey S. The role of nutritional status, airway obstruction, hypoxia, and abnormalities in serum lipid composition in limiting exercise tolerance in children with cystic fibrosis. Acta Paediatr Scand 69: 353-358, 1980.
7. Cystic Fibrosis Foundation. Patient Registry: 2013 Annual Data Report. Bethesda, MD: Cystic Fibrosis Foundation, 2013.
8. de Meer K, Jeneson JA, Gulmans VA, van der Laag J, Berger R. Efficiency of oxidative work performance of skeletal muscle in patients with cystic fibrosis. Thorax 50: 980-983, 1995.
9. Dodd JD, Barry SC, Gallagher CG. Respiratory factors do not limit maximal symptom-limited exercise in patients with mild cystic fibrosis lung disease. Respir Physiol Neurobiol 152: 176-185, 2006.
10. Dufresne V, Knoop C, Van Muylem A, Malfroot A, Lamotte M, Opdekamp C, Deboeck G, Cassart M, Stallenberg B, Casimir G, Duchateau J, Estenne M. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis. Am J Respir Crit Care Med 180: 153-158, 2009.
11. Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, Durie PR, Legrys VA, Massie J, Parad RB, Rock MJ, Campbell PW, 3rd. Guidelines for diagnosis of cystic fibrosis in new-borns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr 153: S4-S14, 2008.
12. Flume PA, O'Sullivan BP, Robinson KA, Goss CH, Mogayzel PJ Jr, Willey-Courand DB, Bujan J, Finder J, Lester M, Quittell L, Rosenblatt R, Vender RL, Hazle L, Sabadosa K, Marshall B. Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health. Am J Respir Crit Care Med 176: 957-969, 2007.
13. Gadsby DC, Dousmanis AG, Nairn AC. ATP hydrolysis cycles and the gating of CFTR Cl-channels. Acta Physiol Scand Suppl 643: 247-256, 1998.
14. Guenette JA, Chin RC, Cheng S, Dominelli PB, Raghavan N, Webb KA, Neder JA, O'Donnell DE. Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD. Eur Respir J 44: 1177-1187, 2014.
15. Guenette JA, Chin RC, Cory JM, Webb KA, O'Donnell DE. Inspira-tory capacity during Exercise: measurement, analysis, and interpretation. Pulm Med 2013: 956081, 2013.
16. Guenette JA, Dominelli PB, Reeve SS, Durkin CM, Eves ND, Sheel AW. Effect of thoracic gas compression and bronchodilation on the assessment of expiratory flow limitation during exercise in healthy humans. Respir Physiol Neurobiol 170: 279-286, 2010.
17. Guenette JA, Jensen D, Webb KA, Ofir D, Raghavan N, O'Donnell DE. Sex differences in exertional dyspnea in patients with mild COPD: physiological mechanisms. Respir Physiol Neurobiol 177: 218-227, 2011.
18. Hey EN, Lloyd BB, Cunningham DJC, Jukes MGM, Bolton DPG. Effects of various respiratory stimuli on the depth and frequency of breathing in man. Respir Physiol 1: 193-205, 1966.
19. Johnson BD, Scanlon PD, Beck KC. Regulation of ventilatory capacity during exercise in asthmatics. J Appl Physiol (1985) 79: 892-901, 1995.
20. Johnson BD, Weisman IM, Zeballos RJ, Beck KC. Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop. Chest 116: 488-503, 1999.
21. Jones NL. Clinical Exercise Testing. Philadelphia, PA: W. B. Saunders, 1988.
22. Kraemer R, Blum A, Schibler A, Ammann RA, Gallati S. Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med 171: 371-378, 2005.
23. Lands LC, Heigenhauser GJ, Jones NL. Analysis of factors limiting maximal exercise performance in cystic fibrosis. Clin Sci (Lond) 83: 391-397, 1992.
24. Laveneziana P, Webb KA, Ora J, Wadell K, O'Donnell DE. Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints. Am J Respir Crit Care Med 184: 1367-1373, 2011.
25. MacIntyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 26: 720-735, 2005.
26. Marcotte JE, Grisdale RK, Levison H, Coates AL, Canny GJ. Multiple factors limit exercise capacity in cystic fibrosis. Pediatr Pulmonol 2: 274-281, 1986.
27. McLoughlin P, McKeogh D, Byrne P, Finlay G, Hayes J, FitzGerald MX. Assessment of fitness in patients with cystic fibrosis and mild lung disease. Thorax 52: 425-430, 1997.
28. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardisation of spirometry. Eur Respir J 26: 319-338, 2005.
29. Moser C, Tirakitsoontorn P, Nussbaum E, Newcomb R, Cooper DM. Muscle size and cardiorespiratory response to exercise in cystic fibrosis. Am J Respir Crit Care Med 162: 1823-1827, 2000.
30. Moss RB, Flume PA, Elborn JS, Cooke J, Rowe SM, McColley SA, Rubenstein RC, Higgins M. Efficacy and safety of ivacaftor in patients with cystic fibrosis who have an Arg117His-CFTR mutation: a double-blind, randomised controlled trial. Lancet Respir Med 3: 524-533, 2015.
31. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346: 793-801, 2002.
32. Neder JA, O'Donnell CD, Cory J, Langer D, Ciavaglia CE, Ling Y, Webb KA, O'Donnell DE. Ventilation distribution heterogeneity at rest as a marker of exercise impairment in mild-to-advanced COPD. COPD 12: 249-256, 2014.
33. O'Donnell DE, Guenette JA, Maltais F, Webb KA. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest 141: 753-762, 2012.
34. Ofir D, Laveneziana P, Webb KA, Lam YM, O'Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177: 622-629, 2008.
35. Pastre J, Prevotat A, Tardif C, Langlois C, Duhamel A, Wallaert B. Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease. BMC Pulm Med 14: 74, 2014.
36. Pianosi P, Pelech A. Stroke volume during exercise in cystic fibrosis. Am J Respir Crit Care Med 153: 1105-1109, 1996.
37. Selvadurai HC, Allen J, Sachinwalla T, Macauley J, Blimkie CJ, Van Asperen PP. Muscle function and resting energy expenditure in female athletes with cystic fibrosis. Am J Respir Crit Care Med 168: 1476-1480, 2003.
38. Selvadurai HC, McKay KO, Blimkie CJ, Cooper PJ, Mellis CM, Van Asperen PP. The relationship between genotype and exercise tolerance in children with cystic fibrosis. Am J Respir Crit Care Med 165: 762-765, 2002.
39. Shapiro BL. Evidence for a mitochondrial lesion in cystic fibrosis. Life Sci 44: 1327-1334, 1989.
40. Stephenson AL, Tom M, Berthiaume Y, Singer LG, Aaron SD, Whitmore GA, Stanojevic S. A contemporary survival analysis of individuals with cystic fibrosis: a cohort study. Eur Respir J 45: 670-679, 2015.
41. Stevens D, Stephenson A, Faughnan ME, Leek E, Tullis E. Prognostic relevance of dynamic hyperinflation during cardiopulmonary exercise testing in adult patients with cystic fibrosis. J Cyst Fibros 12: 655-661, 2013.
42. Stickland MK, Butcher SJ, Marciniuk DD, Bhutani M. Assessing exercise limitation using cardiopulmonary exercise testing. Pulm Med 2012: 824091, 2012.
43. Tiddens HA, Puderbach M, Venegas JG, Ratjen F, Donaldson SH, Davis SD, Rowe SM, Sagel SD, Higgins M, Waltz DA. Novel outcome measures for clinical trials in cystic fibrosis. Pediatr Pulmonol 50: 302-315, 2015.
44. van de Weert-van Leeuwen PB, Slieker MG, Hulzebos HJ, Kruitwa-gen CL, van der Ent CK, Arets HG. Chronic infection and inflammation affect exercise capacity in cystic fibrosis. Eur Respir J 39: 893-898, 2012.
45. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G. Standardisation of the measurement of lung volumes. Eur Respir J 26: 511-522, 2005.