The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department

Clinical Biochemistry

Volumn 48, Issue 18, 2015, Pages 1219-1224

  Pickering, John W ^a,d   Young, Joanna M ^b   George, Peter ^c,d   Aldous, Sally ^a   Cullen, Louise ^e,f,g   Greenslade, Jaimi H ^e,f,g   Richards, A Mark ^d   Troughton, Richard ^a,d   Ardagh, Michael ^a,d   Frampton, Christopher M ^d   Than, Martin P ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b Lipid and Diabetes Research Group   (New Zealand)

^c CANTERBURY HEALTH LABORATORIES   (New Zealand)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Accelerated diagnostic pathway; Acute coronary syndrome; Acute myocardial infarction; Emergency department; Emergency room; High sensitivity troponin; NSTEMI; Stemi

Indexed keywords

BIOLOGICAL MARKER; TROPONIN I;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAM; EMERGENCY WARD; FEMALE; HUMAN; LIMIT OF DETECTION; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY ANALYSIS; SEX; SYMPTOM; THORAX PAIN; AGED; BLOOD; CHEST PAIN; ELECTROCARDIOGRAPHY; EMERGENCY HEALTH SERVICE; MIDDLE AGED; MYOCARDIAL INFARCTION; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEX DIFFERENCE; TIME FACTOR;

ACUTE CORONARY SYNDROME; AGED; BIOMARKERS; CHEST PAIN; COHORT STUDIES; ELECTROCARDIOGRAPHY; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEX FACTORS; TIME FACTORS; TROPONIN I;

EID: 84949109410     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2015.07.033     Document Type: Article

References (33)

1. Hollander J.E. The continuing search to identify the very-low-risk chest pain patient. Acad. Emerg. Med. 1999, 6:979-981.
2. Luepker R.V., Apple F.S., Christenson R.H., Crow R.S., Fortmann S.P., Goff D., et al. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation 2003, 108:2543-2549.
3. Than M.P., Cullen L., Reid C.M., Lim S.H., Aldous S., Ardagh M.W., et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet 2011, 377:1077-1084.
4. Thygesen K., Alpert J.S., White H.D. Universal definition of myocardial infarction. Circulation 2007, 116:2634-2653. on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction.
5. Keller T., Zeller T., Ojeda F., Tzikas S., Lillpopp L., Sinning C., et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011, 306:2684-2693.
6. Reichlin T., Hochholzer W., Bassetti S., Steuer S., Stelzig C., Hartwiger S., et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N. Engl. J. Med. 2009, 361:858-867.
7. Cullen L., French J.K., Briffa T.G., Redfern J., Hammett C.J.K., Brieger D.B., et al. Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry. Med. J. Aust. 2015, 202:36-39.
8. Than M.P., Aldous S., Lord S.J., Goodacre S., Frampton C.M.A., Troughton R., et al. A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial. JAMA Intern. Med. 2014, 174:51-58.
9. Than M.P., Flaws D., Sanders S., Doust J., Glasziou P., Kline J., et al. Development and validation of the emergency department assessment of chest pain score and 2h accelerated diagnostic protocol. Emerg. Med. Australas. 2014, 26:34-44.
10. Hamm C.W., Bassand J.P., Agewall S., Bax J., Boersma E., et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur. Heart J. 2011, 32:2999-3054. Authors/Task Force Members.
11. Giannitsis E., Becker M., Kurz K., Hess G., Zdunek D., Katus H.A. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin. Chem. 2010, 56:642-650.
12. Weber M., Bazzino O., Estrada J.L.N., de Miguel R., Salzberg S., Fuselli J.J., et al. Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome. Am. Heart J. 2011, 162:81-88.
13. Antman E.M., Cohen M., Bernink P.J., McCabe C.H., Horacek T., Papuchis G., et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 2000, 284:835-842.
14. Macrae A.R., Kavsak P.A., Lustig V., Bhargava R., Vandersluis R., Palomaki G.E., et al. Assessing the requirement for the 6-hour interval between specimens in the American Heart Association classification of myocardial infarction in epidemiology and clinical research studies. Clin. Chem. 2006, 52:812-818.
15. National Institute of Health Care Excellence (NICE) Myocardial infarction (acute): early rule out using high-sensitivity troponin tests (Elecsys troponin T high-sensitive, ARCHITECT STAT high sensitive troponin-I and AccuTnI+3 assays) (DG15) http://nice.org.uk/guidance/dg15.
16. Cullen L., Than M.P., Brown A.F.T., Richards M., Parsonage W., Flaws D., et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg. Med. Australas. 2010, 22:35-55.
17. R Core Team R: A Language and Environment for Statistical Computing 2014.
18. Than M.P., Herbert M., Flaws D., Cullen L., Hess E., Hollander J.E., et al. What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the Emergency Department? A clinical survey. Int. J. Cardiol. 2013, 166:752-754.
19. Six A.J., Backus B.E., Kelder J.C. Chest pain in the emergency room: value of the HEART score. Neth. Hear. J. 2008, 16:191-196.
20. Scheuermeyer F.X., Wong H., Yu E., Boychuk B., Innes G., Grafstein E., et al. Development and validation of a prediction rule for early discharge of low-risk emergency department patients with potential ischemic chest pain. CJEM 2014, 16:106-119.
21. Carlton E.W., Cullen L., Than M.P., Gamble J., Khattab A. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart 2015, (On line ahead of print). 10.1136/heartjnl-2014-307288.
22. Apple F.S., Jaffe A.S. Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. Clin. Chem. 2012, 58:1599-1600.
23. Parsonage W.A., Tate J.R., Greenslade J.H., Hammett C.J., Ungerer J.P.J., Pretorius C.J., et al. Effect of recalibration of the hs-TnT assay on diagnostic performance. Clin. Chem. Lab. Med. 2014, 52:e25-e27.
24. Westwood M.E., van Asselt A.D.I., BLT R., Whiting P.F., Thokala P., Armstrong N., et al. High Sensitivity Troponin Assays for the Early Rule-out or Diagnosis of Acute Myocardial Infarction in People With Acute Chest Pain: a Systematic Review and Cost-effectiveness Analysis 2014, 1-250. Kleijnen Systematic Reviews Ltd.
25. Eggers K.M., Aldous S., Greenslade J.H., Johnston N., Lindahl B., Parsonage W.A., et al. Two-hour diagnostic algorithms for early assessment of patients with acute chest pain - implications of lowering the cardiac troponin I cut-off to the 97.5th percentile. Clin. Chim. Acta 2015, 445:19-24.
26. Reichlin T., Schindler C., Drexler B., Twerenbold R., Reiter M., Zellweger C., et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch. Intern. Med. 2012, 172:1211-1218.
27. Reichlin T., Twerenbold R., Wildi K., Rubini Gimenez M., Bergsma N., Haaf P., et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. Can. Med. Assoc. J. 2015, (On line ahead of print). 10.1503/cmaj.141349/-/DC1.
28. Cullen L., Greenslade J., Than M.P., Tate J., Ungerer J.P.J., Pretorius C., et al. Performance of risk stratification for acute coronary syndrome with two-hour sensitive troponin assay results. Heart Lung Circ. 2014, 23:428-434.
29. Druey S., Wildi K., Twerenbold R., Jaeger C., Reichlin T., Haaf P., et al. Early rule-out and rule-in of myocardial infarction using sensitive cardiac troponin I. Int. J. Cardiol. 2015, 195:163-170.
30. Bandstein N., Ljung R., Johansson M., Holzmann M.J. Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction. JACC 2014, 63:2569-2578.
31. Body R., Carley S., McDowell G., Jaffe A.S., France M., Cruickshank K., et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. JACC 2011, 58:1332-1339.
32. Greenslade J.H., Kavsak P., Parsonage W., Shortt C., Than M.P., Pickering J.W., et al. Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain. Clin. Biochem. 2015, 48:288-291.
33. Body R., Burrows G., Carley S., Lewis P.S. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a sensitive troponin I assay. Ann. Clin. Biochem. 2015, (On line ahead of print). 10.1177/0004563215576976.