Hypercarotenodermia in Zambia: Which children turned orange during mango season?

European Journal of Clinical Nutrition

Volumn 69, Issue 12, 2015, Pages 1346-1349

  Tanumihardjo, S A ^a   Gannon, B M ^a   Kaliwile, C ^b   Chileshe, J ^c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b National Food and Nutrition Commission   (Zambia)

^c Tropical Diseases Research Centre Ndola   (Zambia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; CAROTENOID; MARGARINE; RETINOL; RETINOL PALMITATE;

BIOTRANSFORMATION; CHILD NUTRITION; COHORT ANALYSIS; DIETARY REFERENCE INTAKE; DOSE RESPONSE; FOLLOW UP; HUMAN; HYPERCAROTENODERMIA; HYPERVITAMINOSIS; LACTATION; MAIZE; MANGO; MILK; MORTALITY; PRACTICE GUIDELINE; PREGNANCY; REVIEW; RISK FACTOR; RURAL AREA; SEASONAL VARIATION; SUGAR INTAKE; VITAMIN SUPPLEMENTATION; ZAMBIA; ANALOGS AND DERIVATIVES; BLOOD; DIET; DIETARY SUPPLEMENT; EVIDENCE BASED MEDICINE; FORTIFIED FOOD; HYPERVITAMINOSIS A; INFANT; MANGIFERA; NUTRITIONAL STATUS; PATHOLOGY; PRESCHOOL CHILD; RURAL POPULATION; SEASON; SKIN;

BETA CAROTENE; CHILD, PRESCHOOL; DIET; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EVIDENCE-BASED MEDICINE; FOOD, FORTIFIED; HUMANS; HYPERVITAMINOSIS A; INFANT; MANGIFERA; NUTRITIONAL STATUS; RECOMMENDED DIETARY ALLOWANCES; RURAL POPULATION; SEASONS; SKIN; VITAMIN A; ZAMBIA;

EID: 84949109338     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2015.143     Document Type: Review

References (27)

1. WHO Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995-2005 WHO Global Database on Vitamin A Deficiency WHO: Geneva, Switzerland, 2009.
2. Tanumihardjo SA. Vitamin A fortification efforts require accurate monitoring of population vitamin A status to prevent excessive intakes. Proc Chem. 2015; 14: 398-407.
3. Bresnahan K, Chileshe J, Arscott S, Nuss E, Surles R, Masi C, et al. The acute phase response affected traditional measures of micronutrient status in rural Zambian children during a randomized, controlled feeding trial. J Nutr. 2014; 144: 972-978.
4. Gannon B, Kaliwile C, Arscott SA, Schmaelzle S, Chileshe J, Kalungwana N, et al. Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a communitybased, randomized placebo-controlled trial. Am J Clin Nutr. 2014; 100: 1541-1550.
5. Pinkaew S, Wegmuller R, Wasantwisut E, Winichagoon P, Hurrell RF, Tanumihardjo SA. Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-Aged Thai children. J Nutr. 2014; 144: 519-524.
6. Institute of Medicine Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press: Washington, DC, USA, 2001; pp 82-161.
7. Hotz C, Chileshe J, Siamusantu W, Palaniappan U, Kafwembe E. Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia. Public Health Nutr. 2012; 15: 1688-1696.
8. Stephensen CB, Franchi LM, Hernandez H, Campos M, Colarossi A, Gilman RH, et al. Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia. Am J Clin Nutr. 2002; 76: 1351-1357.
9. Wieringa FT, Dijkhuizen MA, West CE, Northrop-Clewes CA, Muhilal. Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr. 2002; 132: 3061-3066.
10. Nuss ET, Arscott SA, Bresnahan K, Pixley KV, Rocheford T, Hotz C, et al. Comparative intake of white- versus orange-colored maize by Zambian children in the context of promotion of biofortified maize. Food Nutr Bull. 2012; 33: 63-71.
11. Tanumihardjo SA. Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr. 2011; 94: 658S-665S.
12. Schmaelzle S, Kaliwile C, Arscott SA, Gannon B, Masi C, Tanumihardjo SA. Nutrient and non-Traditional food intakes by Zambian children in a controlled feeding trial. Food Nutr Bull. 2014; 35: 60-67.
13. The World Bank Mortality rate, under-5 (per 1, 000 live births) Available at http://.data.worldbank.org/indicator/SH.DYN.MORT (last accessed 22 September 2014
14. Tanumihardjo SA, Gannon BM, Kaliwile C, Chileshe J. Reply to G Lietz, et al. Am J Clin Nutr. 2015; 102: 521-522.
15. Vijayalakshmi AM. Carotenodermia. Indian Pediatr. 2008; 45: 61.
16. Ross AC, Zolfaghari R. Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J Nutr. 2004; 134: 269S-275S.
17. Hathcock JN, Hattan DG, Jenkins MY, McDonald JT, Sundaresan PR, Wilkening VL. Evaluation of vitamin A toxicity. Am J Clin Nutr. 1990; 52: 183-202.
18. Tanumihardjo SA. Vitamin A and bone health: the balancing act. J Clin Densitom. 2013; 16: 414-419.
19. Mondloch S, Gannon BM, Davis CR, Chileshe J, Kaliwile C, Masi C, et al. High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in Zambian preschool children are consistent with the presence of high liver vitamin A stores. Am J Clin Nutr. 2015; 102: 497-504.
20. Valentine AR, Davis CR, Tanumihardjo SA. Vitamin A isotope dilution predicts liver stores in line with long-Term vitamin A intake above the current Recommended Dietary Allowance for young adult women. Am J Clin Nutr. 2013; 98: 1192-1199.
21. Penniston KL, Tanumihardjo SA. Subtoxic hepatic vitamin A concentrations in captive rhesus monkeys (Macaca mulatta). J Nutr. 2001; 131: 2904-2909.
22. Olson JA. Vitamin A. In: Brown ML (ed). Present Knowledge in Nutrition, 6th edn. International Life Sciences Institute: Washington DC, USA, 1990, pp 101.
23. Riabroy N, Dever J, Tanumihardjo SA. Retinol and 3, 4-didehydroretinol support growth in rats when fed at equimolar amounts and a-retinol is not toxic after repeated administration of large doses. Br J Nutr. 2014; 111: 1373-1381.
24. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006; 83: 191-201.
25. Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. N Engl J Med. 1976; 294: 805-808.
26. Mallia AK, Smith JE, Goodman DS. Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat. J Lipid Res. 1975; 16: 180-188.
27. Jahns L, Johnson LK, Mayne ST, Cartmel B, Picklo MJ Sr, Ermakov IV, et al. Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics. Am J Clin Nutr. 2014; 100: 930-937.