α-Retinol and 3,4-didehydroretinol support growth in rats when fed at equimolar amounts and α-retinol is not toxic after repeated administration of large doses

British Journal of Nutrition

Volumn 111, Issue 8, 2014, Pages 1373-1381

  Riabroy, Napaporn ^a   Dever, Joseph T ^a   Tanumihardjo, Sherry A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Bioactivities; Carrots; Carotene

Indexed keywords

ALPHA RETINOL; DEHYDRORETINOL; RETINOL ACETATE; RETINOL DERIVATIVE; UNCLASSIFIED DRUG; COTTON SEED OIL; RETINOIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; GROWTH RATE; KIDNEY MASS; LIVER; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; RAT; RETINOL DEFICIENCY; VITAMIN DEFICIENCY; BIOACCUMULATION; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; DIET SUPPLEMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; KIDNEY; LUNG; REPEATED DRUG DOSE; SPLEEN; TOXICITY TESTING; VITAMIN METABOLISM;

DAUCUS CAROTA; MICROPUS; RATTUS;

ANIMALS; AREA UNDER CURVE; BODY WEIGHT; DIET; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GROWTH; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN A; VITAMIN A DEFICIENCY; WEANING;

EID: 84897114825     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513003851     Document Type: Article

References (38)

1. Ames SR, Swanson WJ & Harris PL (1955) Biochemical studies on vitamin A. XV. Biopotencies of geometric isomers of vitamin A aldehyde in the rat. J Am Chem Soc 77, 4136-4138
2. Goodman DS, Smith JE, Hembry RM, et al. (1974) Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat. J Lipid Res 15, 406-414
3. Sneider WD, Rosso GC, Rogers AE, et al. (1974) The partial vitamin A function of a-retinol. J Nutr 104, 1662-1668
4. Pitt GAJ (1978) a-Retinol. Wld Rev Nutr Diet 31, 65-70
5. Pitt GAJ (1983) Chemical structure and the changing concept of vitamin A activity. Proc Nutr Soc 42, 43-51
6. Pitt GAJ (1969) Comment on the metabolic function of vitamin A. Am J Clin Nutr 22, 1045-1046
7. Houghton SE (1969) a-Retinol. PhD Thesis, University of Liverpool
8. Shantz EM & Brinkman JH (1950) Biological activity of pure vitamin A2. J Biol Chem 183, 467-471
9. Tanumihardjo SA & Howe JA (2005) Twice the amount of a-carotene isolated from carrots is as effective as b-carotene in maintaining the vitamin A status of Mongolian gerbils. J Nutr 135, 2622-2626
10. Combs GF Jr (2007) Vitamin A. In Vitamins: Fundamental Aspects in Nutrition and Health, 3rd ed., pp. 95-144. Burlington, MA: Academic Press
11. Mills JP, Furr HC & Tanumihardjo SA (2008) Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Exp Biol Med 233, 1255-1261
12. Dew SE & Ong DE (1994) Specificity of the retinol transporter of the rat small intestine brush border. Biochemistry 33, 12340-12345
13. Muhilal H & Glover J (1975) The affinity of retinol and its analogues for retinol-binding protein. Biochem Soc Trans 3, 744-746
14. Furusho T, Kataoka E, Yasuhara T, et al. (2000) Retinol equivalent of carotenoids can be evaluated by hepatic vitamin A content. Int J Vitam Nutr Res 2, 43-47
15. Green MH & Green JB (1994) Vitamin A intake and status influence retinol balance, utilization and dynamics in rats. J Nutr 124, 2477-2485
16. Tanumihardjo SA (2001) Synthesis of 10, 14, 15-13C4-And 14, 15-13C2-retinyl acetate. J Labelled Cpd Radiopharm 44, 365-372
17. Tanumihardjo SA, Barua AB & Olson JA (1987) Use of 3,4-didehydroretinol to assess vitamin A status in rats. Int J Vitam Nutr Res 57, 127-132
18. Escaron AL, Green MH & Tanumihardjo SA (2009) Plasma turnover of 3,4-didehydroretinol (vitamin A2) increases in vitamin A-deficient rats fed low versus high dietary fat. J Lipid Res 50, 694-703
19. Adams WR & Green MH (1994) Prediction of liver vitamin A in rats by an oral isotope dilution technique. J Nutr 124, 1265-1270
20. Kelley SK & Green MH (1998) Plasma retinol is a major determinant of vitamin A utilization in rats. J Nutr 128, 1767-1773
21. Sun T, Surles RL & Tanumihardjo SA (2008) Vitamin A concentrations in piglet extrahepatic tissues respond differently ten days after vitamin A treatment. J Nutr 138, 1101-1106
22. Tanumihardjo SA (2000) Vitamin A status assessment in rats using 13C4-retinyl acetate and gas chromatography-combustion isotope ratio mass spectrometry (GCCIRMS). J Nutr 130, 2844-2849
23. Ross AC & Li N (2007) Lung retinyl ester is low in young adult rats fed a vitamin A-deficient diet after weaning, despite neonatal vitamin A supplementation and maintenance of normal plasma retinol. J Nutr 137, 2213-2218
24. Clamon GH, Sporn MB, Smith, et al. (1974) a-And b-Retinyl acetate reverse metaplasias of vitamin A deficiency in hamster trachea in organ culture. Nature 250, 64-66
25. Jensen JL, Shantz EM, Embree ND, et al. (1943) The biological activity of vitamin A2. J Biol Chem 149, 473-477
26. Quadro L, Blaner WS, Salchow DJ, et al. (1999) Visual defect and impaired retinoid availability in mice lacking retinolbinding protein. EMBO J 18, 4633-4644
27. Dever JT, Surles RL, Davis CR, et al. (2011) a-Retinol is distributed through serum retinol-binding protein-independent mechanisms in the lactating sow-nursing piglet dyad. J Nutr 141, 42-47
28. Quadro L, Hamberger L, Gottesman ME, et al. (2004) Transplacental delivery of retinoid: The role of retinol-binding protein and lipoprotein retinyl ester. Am J Physiol Endocrinol Metab 286, E844-E851
29. De Lera AR, Bourguet W, Altucci L, et al. (2007) Design of selective nuclear receptor modulators: RAR and RXR as a case study. Nature Rev Drug Discov 6, 811-820
30. Sani BP, Venepally PR & Levin AA (1997) Didehydroretinoic acid: Retinoid receptor-mediated transcriptional activation and binding properties. Biochem Pharmacol 53, 1049-1053
31. Repa JJ, Plum LA, Tadikonda PK, et al. (1996) All-Trans 3,4-didehydroretinoic acid equals all-Trans retinoic acid in support of chick neuronal development. FASEB J 10, 1078-1084
32. Duitsman PK & Olson JA (1996) Comparative embryolethality and teratogenicity of the all-Trans isomers of retinoic acid, 3,4-didehydroretinyl acetate, and retinyl acetate in pregnant rats. Teratology 53, 237-244
33. Tanumihardjo SA (2011) Vitamin A: Biomarkers of nutrition for development. Am J Clin Nutr 94, S658-S665
34. Howell JM, Thompson JN & Pitt GAJ (1967) Reproduction and vision in rats maintained on a retinol-free diet containing 3-dehydroretinol (vitamin A2). Br J Nutr 21, 373-376
35. Millard EB Jr & McCann WS (1949) Effect of vitamin A2 on the red and blue threshold of fully dark adapted vision. J Appl Physiol 1, 807-810
36. Green MH, Green JB & Lewis KC (1987) Variation in retinol utilization rate with vitamin A status in the rat. J Nutr 117, 694-703
37. During A, Dawson HD & Harrison EH (2005) Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr 135, 2305-2312
38. Penniston KL & Tanumihardjo SA (2006) The acute and chronic toxic effects of vitamin A: A review. Am J Clin Nutr 83, 191-201.