Nanoparticles Containing High Loads of Paclitaxel-Silicate Prodrugs: Formulation, Drug Release, and Anticancer Efficacy

Molecular Pharmaceutics

Volumn 12, Issue 12, 2015, Pages 4329-4335

  Han, Jing ^a   Michel, Andrew R ^a   Lee, Han Seung ^a   Kalscheuer, Stephen ^b   Wohl, Adam ^a   Hoye, Thomas R ^a   McCormick, Alon V ^a   Panyam, Jayanth ^b   Macosko, Christopher W ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

anticancer efficacy; drug release; flash nanoprecipitation; nanoparticles; paclitaxel; prodrug; silicate

Indexed keywords

ALKYL GROUP; ANTINEOPLASTIC AGENT; NANOPARTICLE; PACLITAXEL; PACLITAXEL DERIVATIVE; PACLITAXEL SILICATE PRODRUG; SILICATE; UNCLASSIFIED DRUG; DRUG CARRIER; MACROGOL DERIVATIVE; POLY(LACTIC-GLYCOLIC ACID)-POLY(ETHYLENEGLYCOL) COPOLYMER; POLYGLACTIN; PRODRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CONFINED IMPINGEMENT JET MIXER WITH A DILUTION; CONTROLLED STUDY; CYTOTOXICITY; DERIVATIZATION; DILUTION; DISPERSION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; FEMALE; FLASH NANOPRECIPITATION; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; IC50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; SLOW DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; MEDICINAL CHEMISTRY; NUDE MOUSE; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG LIBERATION; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; PACLITAXEL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; PRODRUGS; SILICATES;

EID: 84949035033     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00530     Document Type: Article

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