메뉴 건너뛰기




Volumn 70, Issue 11, 2015, Pages 3074-3079

Class-specific relative genetic contribution for key antiretroviral drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; ATAZANAVIR PLUS RITONAVIR; EFAVIRENZ; ETRAVIRINE; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NEVIRAPINE; RALTEGRAVIR; TENOFOVIR;

EID: 84949034609     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv207     Document Type: Article
Times cited : (12)

References (44)
  • 2
    • 78650322209 scopus 로고    scopus 로고
    • Comparative evaluation of seven resistance interpretation algorithms and their derived genotypic inhibitory quotients for the prediction of 48 week virological response to darunavir-based salvage regimens
    • Gonzalez de Requena D, Bonora S, Vigano O et al. Comparative evaluation of seven resistance interpretation algorithms and their derived genotypic inhibitory quotients for the prediction of 48 week virological response to darunavir-based salvage regimens. J Antimicrob Chemother 2011; 66: 192-200.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 192-200
    • Gonzalez de Requena, D.1    Bonora, S.2    Vigano, O.3
  • 3
    • 33745077340 scopus 로고    scopus 로고
    • A pharmacokinetic-pharmacodynamic model to optimize the phase IIa development program of maraviroc
    • Rosario MC, Poland B, Sullivan J et al. A pharmacokinetic-pharmacodynamic model to optimize the phase IIa development program of maraviroc. J Acquir Immune Defic Syndr 2006; 42: 183-91.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 183-191
    • Rosario, M.C.1    Poland, B.2    Sullivan, J.3
  • 4
    • 84893761410 scopus 로고    scopus 로고
    • Maraviroc (MVC) exposure - efficacy relationship in treatment-experienced HIV-1-infected patients
    • Madrid, Spain, Poster P4.1/06
    • McFadyen L, Jacqmin P, Wade JR et al. Maraviroc (MVC) exposure - efficacy relationship in treatment-experienced HIV-1-infected patients. In: AIDS Conference/EACS, Madrid, Spain, 2007. Poster P4.1/06.
    • (2007) In: AIDS Conference/EACS
    • McFadyen, L.1    Jacqmin, P.2    Wade, J.R.3
  • 5
    • 42049102201 scopus 로고    scopus 로고
    • Inhibitory quotient in HIV pharmacology
    • la Porte C. Inhibitory quotient in HIV pharmacology. Curr Opin HIV AIDS 2008; 3: 283-7.
    • (2008) Curr Opin HIV AIDS , vol.3 , pp. 283-287
    • la Porte, C.1
  • 6
    • 75649091119 scopus 로고    scopus 로고
    • HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
    • Hartkoorn RC, Kwan WS, Shallcross V et al. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenet Genomics 2010; 20: 112-20.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 112-120
    • Hartkoorn, R.C.1    Kwan, W.S.2    Shallcross, V.3
  • 8
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
    • Kassahun K, McIntosh I, Cui D et al. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Drug Metab Dispos 2007; 35: 1657-63.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1657-1663
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 11
    • 84920163703 scopus 로고    scopus 로고
    • Bioequivalence of a darunavir/cobicistat fixed-dose combination tablet versus single agents and food effect in healthy volunteers
    • Kakuda TN, Van De Casteele T, Petrovic R et al. Bioequivalence of a darunavir/cobicistat fixed-dose combination tablet versus single agents and food effect in healthy volunteers. Antivir Ther 2014; 19: 597-606.
    • (2014) Antivir Ther , vol.19 , pp. 597-606
    • Kakuda, T.N.1    Van De Casteele, T.2    Petrovic, R.3
  • 12
    • 84885037903 scopus 로고    scopus 로고
    • Impact of food and different meal types on the pharmacokinetics of rilpivirine
    • Crauwels HM, van Heeswijk RP, Buelens A et al. Impact of food and different meal types on the pharmacokinetics of rilpivirine. J Clin Pharmacol 2013; 53: 834-40.
    • (2013) J Clin Pharmacol , vol.53 , pp. 834-840
    • Crauwels, H.M.1    van Heeswijk, R.P.2    Buelens, A.3
  • 13
    • 84879477892 scopus 로고    scopus 로고
    • Predicting intestinal absorption of raltegravir using a population-based ADME simulation
    • Moss DM, Siccardi M, Back DJ et al. Predicting intestinal absorption of raltegravir using a population-based ADME simulation. J Antimicrob Chemother 2013; 68: 1627-34.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 1627-1634
    • Moss, D.M.1    Siccardi, M.2    Back, D.J.3
  • 14
    • 84861119863 scopus 로고    scopus 로고
    • Divalent metals and pH alter raltegravir disposition in vitro
    • Moss DM, Siccardi M, Murphy M et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother 2012; 56: 3020-6.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3020-3026
    • Moss, D.M.1    Siccardi, M.2    Murphy, M.3
  • 15
    • 65449118348 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 516G→T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population
    • Mahungu T, Smith C, Turner F et al. Cytochrome P450 2B6 516G→T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population. HIV Med 2009; 10: 310-7.
    • (2009) HIV Med , vol.10 , pp. 310-317
    • Mahungu, T.1    Smith, C.2    Turner, F.3
  • 16
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H et al. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005; 15: 1-5.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 17
    • 37349034567 scopus 로고    scopus 로고
    • CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    • Saitoh A, Sarles E, Capparelli E et al. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS 2007; 21: 2191-9.
    • (2007) AIDS , vol.21 , pp. 2191-2199
    • Saitoh, A.1    Sarles, E.2    Capparelli, E.3
  • 18
    • 27944492382 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz
    • Klein K, Lang T, Saussele Tet al. Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz. Pharmacogenet Genomics 2005; 15: 861-73.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 861-873
    • Klein, K.1    Lang, T.2    Saussele, T.3
  • 19
    • 78549265829 scopus 로고    scopus 로고
    • Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T > C polymorphism
    • Siccardi M, D'Avolio A, Nozza S et al. Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T > C polymorphism. Pharmacogenet Genomics 2010; 20: 759-65.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 759-765
    • Siccardi, M.1    D'Avolio, A.2    Nozza, S.3
  • 20
    • 53349160769 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C→T) with reduced concentrations of unboosted atazanavir
    • Siccardi M, D'Avolio A, Baietto L et al. Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C→T) with reduced concentrations of unboosted atazanavir. Clin Infect Dis 2008; 47: 1222-5.
    • (2008) Clin Infect Dis , vol.47 , pp. 1222-1225
    • Siccardi, M.1    D'Avolio, A.2    Baietto, L.3
  • 21
    • 84865709630 scopus 로고    scopus 로고
    • Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults
    • Schipani A, Egan D, Dickinson L et al. Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults. Antivir Ther 2012; 17: 861-8.
    • (2012) Antivir Ther , vol.17 , pp. 861-868
    • Schipani, A.1    Egan, D.2    Dickinson, L.3
  • 22
    • 80051685348 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens
    • Wyen C, Hendra H, SiccardiMet al. Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. J Antimicrob Chemother 2011; 66: 2092-8.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2092-2098
    • Wyen, C.1    Hendra, H.2    Siccardi, M.3
  • 23
    • 79956053313 scopus 로고    scopus 로고
    • Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals
    • Schipani A, Wyen C, Mahungu T et al. Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals. J Antimicrob Chemother 2011; 66: 1332-9.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1332-1339
    • Schipani, A.1    Wyen, C.2    Mahungu, T.3
  • 24
    • 83655201204 scopus 로고    scopus 로고
    • Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS
    • Liptrott NJ, Pushpakom S, Wyen C et al. Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenet Genomics 2012; 22: 10-9.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 10-19
    • Liptrott, N.J.1    Pushpakom, S.2    Wyen, C.3
  • 25
    • 79957933957 scopus 로고    scopus 로고
    • Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction
    • Pushpakom SP, Liptrott NJ, Rodriguez-Novoa S et al. Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis 2011; 204: 145-53.
    • (2011) J Infect Dis , vol.204 , pp. 145-153
    • Pushpakom, S.P.1    Liptrott, N.J.2    Rodriguez-Novoa, S.3
  • 26
    • 84872843667 scopus 로고    scopus 로고
    • Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor
    • Cortes CP, Siccardi M, Chaikan A et al. Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor. Ther Drug Monit 2013; 35: 78-83.
    • (2013) Ther Drug Monit , vol.35 , pp. 78-83
    • Cortes, C.P.1    Siccardi, M.2    Chaikan, A.3
  • 27
    • 72949097439 scopus 로고    scopus 로고
    • The impact of SLCO1B1 polymorphisms on the plasma concentration of lopinavir and ritonavir in HIV-infected men
    • Kohlrausch FB, de Cassia Estrela R, Barroso PF et al. The impact of SLCO1B1 polymorphisms on the plasma concentration of lopinavir and ritonavir in HIV-infected men. Br J Clin Pharmacol 2010; 69: 95-8.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 95-98
    • Kohlrausch, F.B.1    de Cassia Estrela, R.2    Barroso, P.F.3
  • 28
    • 84906060907 scopus 로고    scopus 로고
    • CYP3A4*22 (c.522-191 C.T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults
    • Olagunju A, Schipani A, Siccardi M et al. CYP3A4*22 (c.522-191 C.T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults. Pharmacogenet Genomics 2014; 24: 459-63.
    • (2014) Pharmacogenet Genomics , vol.24 , pp. 459-463
    • Olagunju, A.1    Schipani, A.2    Siccardi, M.3
  • 29
    • 84871927320 scopus 로고    scopus 로고
    • Pharmacogeneticsbased population pharmacokinetic analysis of etravirine in HIV-1 infected individuals
    • Lubomirov R, Arab-Alameddine M, Rotger M et al. Pharmacogeneticsbased population pharmacokinetic analysis of etravirine in HIV-1 infected individuals. Pharmacogenet Genomics 2013; 23: 9-18.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 9-18
    • Lubomirov, R.1    Arab-Alameddine, M.2    Rotger, M.3
  • 30
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research
    • Kalow W, Tang BK, Endrenyi L. Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics 1998; 8: 283-9.
    • (1998) Pharmacogenetics , vol.8 , pp. 283-289
    • Kalow, W.1    Tang, B.K.2    Endrenyi, L.3
  • 31
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method
    • Ozdemir V, Kalow W, Tang BK et al. Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics 2000; 10: 373-88.
    • (2000) Pharmacogenetics , vol.10 , pp. 373-388
    • Ozdemir, V.1    Kalow, W.2    Tang, B.K.3
  • 32
    • 0141649391 scopus 로고    scopus 로고
    • Estimating the contribution of genes and environment to variation in renal drug clearance
    • Leabman MK, Giacomini KM. Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics 2003; 13: 581-4.
    • (2003) Pharmacogenetics , vol.13 , pp. 581-584
    • Leabman, M.K.1    Giacomini, K.M.2
  • 33
    • 84886583431 scopus 로고    scopus 로고
    • Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
    • Micheli JE, Chinn LW, Shugarts SB et al. Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes? Pharmacogenet Genomics 2013; 23: 591-6.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 591-596
    • Micheli, J.E.1    Chinn, L.W.2    Shugarts, S.B.3
  • 34
    • 57749207753 scopus 로고    scopus 로고
    • An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients
    • D'Avolio A, Baietto L, Siccardi M et al. An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients. Ther Drug Monit 2008; 30: 662-9.
    • (2008) Ther Drug Monit , vol.30 , pp. 662-669
    • D'Avolio, A.1    Baietto, L.2    Siccardi, M.3
  • 35
    • 75649121808 scopus 로고    scopus 로고
    • A validated high-performance liquid chromatography-ultraviolet method for quantification of the CCR5 inhibitor maraviroc in plasma of HIV-infected patients
    • D'Avolio A, Simiele M, Baietto L et al. A validated high-performance liquid chromatography-ultraviolet method for quantification of the CCR5 inhibitor maraviroc in plasma of HIV-infected patients. Ther Drug Monit 2010; 32: 86-92.
    • (2010) Ther Drug Monit , vol.32 , pp. 86-92
    • D'Avolio, A.1    Simiele, M.2    Baietto, L.3
  • 36
    • 47549094341 scopus 로고    scopus 로고
    • A new assay based on solidphase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients
    • D'Avolio A, Sciandra M, Siccardi M et al. A new assay based on solidphase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients. J Chromatogr Sci 2008; 46: 524-8.
    • (2008) J Chromatogr Sci , vol.46 , pp. 524-528
    • D'Avolio, A.1    Sciandra, M.2    Siccardi, M.3
  • 37
    • 67349205036 scopus 로고    scopus 로고
    • Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals
    • Arab-Alameddine M, Di Iulio J, Buclin T et al. Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals. Clin Pharmacol Ther 2009; 85: 485-94.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 485-494
    • Arab-Alameddine, M.1    Di Iulio, J.2    Buclin, T.3
  • 38
    • 77952322356 scopus 로고    scopus 로고
    • CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    • Kwara A, Lartey M, Sagoe KWet al. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. AIDS 2009; 23: 2101-6.
    • (2009) AIDS , vol.23 , pp. 2101-2106
    • Kwara, A.1    Lartey, M.2    Sagoe, K.W.3
  • 39
    • 0033664988 scopus 로고    scopus 로고
    • Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism
    • Van Gelder J, Deferme S, Annaert P et al. Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism. Drug Metab Dispos 2000; 28: 1394-6.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1394-1396
    • Van Gelder, J.1    Deferme, S.2    Annaert, P.3
  • 40
    • 0036326062 scopus 로고    scopus 로고
    • Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures
    • van Gelder J, Deferme S, Naesens L et al. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. Drug Metab Dispos 2002; 30: 924-30.
    • (2002) Drug Metab Dispos , vol.30 , pp. 924-930
    • van Gelder, J.1    Deferme, S.2    Naesens, L.3
  • 41
    • 84910629450 scopus 로고    scopus 로고
    • The role of drug transporters in the kidney: lessons from tenofovir
    • Moss DM, Neary M, Owen A. The role of drug transporters in the kidney: lessons from tenofovir. Front Pharmacol 2014; 5: 248.
    • (2014) Front Pharmacol , vol.5 , pp. 248
    • Moss, D.M.1    Neary, M.2    Owen, A.3
  • 42
    • 84858707104 scopus 로고    scopus 로고
    • Intrapatient and interpatient pharmacokinetic variability of raltegravir in the clinical setting
    • Siccardi M, D'Avolio A, Rodriguez-Novoa S et al. Intrapatient and interpatient pharmacokinetic variability of raltegravir in the clinical setting. Ther Drug Monit 2012; 34: 232-5.
    • (2012) Ther Drug Monit , vol.34 , pp. 232-235
    • Siccardi, M.1    D'Avolio, A.2    Rodriguez-Novoa, S.3
  • 43
    • 84864247327 scopus 로고    scopus 로고
    • Short communication: lack of correlation between UGT1A1*6, *28 genotypes, and plasma raltegravir concentrations in Japanese HIV type 1-infected patients
    • Hirano A, Ikemura K, Takahashi M et al. Short communication: lack of correlation between UGT1A1*6, *28 genotypes, and plasma raltegravir concentrations in Japanese HIV type 1-infected patients. AIDS Res Hum Retroviruses 2012; 28: 776-9.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 776-779
    • Hirano, A.1    Ikemura, K.2    Takahashi, M.3
  • 44
    • 67349217885 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
    • Wenning LA, Petry AS, Kost JT et al. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther 2009; 85: 623-7.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 623-627
    • Wenning, L.A.1    Petry, A.S.2    Kost, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.