메뉴 건너뛰기




Volumn 126, Issue 20, 2015, Pages 2284-2290

Carfilzomib, pomalidomide, and dexamethasone for relapsed or refractory myeloma

(14)  Shah, Jatin J a   Stadtmauer, Edward A b   Abonour, Rafat c   Cohen, Adam D d   Bensinger, William I e   Gasparetto, Cristina f   Kaufman, Jonathan L g   Lentzsch, Suzanne h   Vogl, Dan T b   Gomes, Christina L i   Pascucci, Natalia i   Smith, David D j   Orlowski, Robert Z a   Durie, Brian G M k  


Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARFILZOMIB; CREATININE; DEXAMETHASONE; LENALIDOMIDE; POMALIDOMIDE; ANTINEOPLASTIC AGENT; OLIGOPEPTIDE; THALIDOMIDE;

EID: 84949032591     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-05-643320     Document Type: Article
Times cited : (205)

References (35)
  • 1
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341(21): 1565-1571.
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 2
    • 36349010285 scopus 로고    scopus 로고
    • Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber DM, Chen C, Niesvizky R, et al; Multiple Myeloma (009) Study Investigators. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med. 2007; 357(21):2133-2142.
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3
  • 3
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Chen C, Spencer A, et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia. 2009;23(11):2147-2152.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3
  • 4
    • 34548539381 scopus 로고    scopus 로고
    • Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
    • Orlowski RZ, Nagler A, Sonneveld P, et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol. 2007;25(25): 3892-3901.
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3892-3901
    • Orlowski, R.Z.1    Nagler, A.2    Sonneveld, P.3
  • 6
    • 75149186681 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone in relapsed/refractory multiple myeloma (MM): Encouraging outcomes and tolerability in a phase II study
    • Anderson KC, Jagannath S, Jakubowiak A, et al. Lenalidomide, bortezomib, and dexamethasone in relapsed/refractory multiple myeloma (MM): encouraging outcomes and tolerability in a phase II study. J Clin Oncol. 2009;2009(15S):8536.
    • (2009) J Clin Oncol , vol.2009 , Issue.15 S , pp. 8536
    • Anderson, K.C.1    Jagannath, S.2    Jakubowiak, A.3
  • 7
    • 84873337611 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid), bortezomib (Velcade) and dexamethasone for heavily pretreated relapsed or refractory multiple myeloma
    • Jimenez-Zepeda VH, Reece DE, Trudel S, Chen C, Tiedemann R, Kukreti V. Lenalidomide (Revlimid), bortezomib (Velcade) and dexamethasone for heavily pretreated relapsed or refractory multiple myeloma. Leuk Lymphoma. 2013;54(3):555-560.
    • (2013) Leuk Lymphoma , vol.54 , Issue.3 , pp. 555-560
    • Jimenez-Zepeda, V.H.1    Reece, D.E.2    Trudel, S.3    Chen, C.4    Tiedemann, R.5    Kukreti, V.6
  • 8
    • 84860898706 scopus 로고    scopus 로고
    • Cyclophosphamide-bortezomibdexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis
    • Mikhael JR, Schuster SR, Jimenez-Zepeda VH, et al. Cyclophosphamide-bortezomibdexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis. Blood. 2012;119(19):4391-4394.
    • (2012) Blood , vol.119 , Issue.19 , pp. 4391-4394
    • Mikhael, J.R.1    Schuster, S.R.2    Jimenez-Zepeda, V.H.3
  • 9
    • 67650882695 scopus 로고    scopus 로고
    • Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: High response rates in a phase II clinical trial
    • Reeder CB, Reece DE, Kukreti V, et al. Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial. Leukemia. 2009;23(7):1337-1341.
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1337-1341
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3
  • 10
    • 77951453409 scopus 로고    scopus 로고
    • Once- versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma
    • Reeder CB, Reece DE, Kukreti V, et al. Once- versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma. Blood. 2010;115(16):3416-3417.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3416-3417
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3
  • 11
    • 84938970441 scopus 로고    scopus 로고
    • Phase III trial of bortezomib, cyclophosphamide and dexamethasone (VCD) versus bortezomib, doxorubicin and dexamethasone (PAd) in newly diagnosed myeloma
    • Mai EK, Bertsch U, Dürig J, et al. Phase III trial of bortezomib, cyclophosphamide and dexamethasone (VCD) versus bortezomib, doxorubicin and dexamethasone (PAd) in newly diagnosed myeloma. Leukemia. 2015;29(8): 1721-1729.
    • (2015) Leukemia , vol.29 , Issue.8 , pp. 1721-1729
    • Mai, E.K.1    Bertsch, U.2    Dürig, J.3
  • 12
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol. 2009;27(34):5713-5719.
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 13
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood. 2010;116(5): 679-686.
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 14
    • 84893289821 scopus 로고    scopus 로고
    • A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma
    • Richardson PG, Xie W, Jagannath S, et al. A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. Blood. 2014; 123(10):1461-1469.
    • (2014) Blood , vol.123 , Issue.10 , pp. 1461-1469
    • Richardson, P.G.1    Xie, W.2    Jagannath, S.3
  • 15
    • 84920599743 scopus 로고    scopus 로고
    • Carfilzomib lenalidomide and dexamethasone for relapsed multiple myeloma
    • Stewart AK, Rajkumar SV, Dimopoulos MA, et al; ASPIRE Investigators. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015;372(2):142-152.
    • (2015) N Engl J Med , vol.372 , Issue.2 , pp. 142-152
    • ASPIRE Investigators1    Stewart, A.K.2    Rajkumar, S.V.3    Dimopoulos, M.A.4
  • 16
    • 84883472160 scopus 로고    scopus 로고
    • U. S. Food and Drug Administration approval: Carfilzomib for the treatment of multiple myeloma
    • Herndon TM, Deisseroth A, Kaminskas E, et al. U. S. Food and Drug Administration approval: carfilzomib for the treatment of multiple myeloma. Clin Cancer Res. 2013;19(17):4559-4563.
    • (2013) Clin Cancer Res , vol.19 , Issue.17 , pp. 4559-4563
    • Herndon, T.M.1    Deisseroth, A.2    Kaminskas, E.3
  • 17
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • Siegel DS, Martin T, Wang M, et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood. 2012;120(14):2817-2825.
    • (2012) Blood , vol.120 , Issue.14 , pp. 2817-2825
    • Siegel, D.S.1    Martin, T.2    Wang, M.3
  • 18
    • 84862507585 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 (PX-171-004) study of singleagent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
    • Vij R, Wang M, Kaufman JL, et al. An open-label, single-arm, phase 2 (PX-171-004) study of singleagent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma. Blood. 2012;119(24):5661-5670.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5661-5670
    • Vij, R.1    Wang, M.2    Kaufman, J.L.3
  • 19
    • 84865552564 scopus 로고    scopus 로고
    • An openlabel, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
    • Vij R, Siegel DS, Jagannath S, et al. An openlabel, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br J Haematol. 2012;158(6):739-748.
    • (2012) Br J Haematol , vol.158 , Issue.6 , pp. 739-748
    • Vij, R.1    Siegel, D.S.2    Jagannath, S.3
  • 20
    • 4344693453 scopus 로고    scopus 로고
    • Phase i study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
    • Schey SA, Fields P, Bartlett JB, et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J Clin Oncol. 2004;22(16): 3269-3276.
    • (2004) J Clin Oncol , vol.22 , Issue.16 , pp. 3269-3276
    • Schey, S.A.1    Fields, P.2    Bartlett, J.B.3
  • 21
    • 84892576029 scopus 로고    scopus 로고
    • Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
    • Krönke J, Udeshi ND, Narla A, et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014; 343(6168):301-305.
    • (2014) Science , vol.343 , Issue.6168 , pp. 301-305
    • Krönke, J.1    Udeshi, N.D.2    Narla, A.3
  • 22
    • 84892593087 scopus 로고    scopus 로고
    • The myeloma drug lenalidomide promotes the cereblondependent destruction of Ikaros proteins
    • Lu G, Middleton RE, Sun H, et al. The myeloma drug lenalidomide promotes the cereblondependent destruction of Ikaros proteins. Science. 2014;343(6168):305-309.
    • (2014) Science , vol.343 , Issue.6168 , pp. 305-309
    • Lu, G.1    Middleton, R.E.2    Sun, H.3
  • 23
    • 84988241358 scopus 로고    scopus 로고
    • International uniform response criteria for multiple myeloma
    • Durie BG, Harousseau JL, Miguel JS, et al; International Myeloma Working Group. International uniform response criteria for multiple myeloma. Leukemia. 2006;20(9):1467-1473.
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1467-1473
    • Durie, B.G.1    Harousseau, J.L.2    Miguel, J.S.3
  • 24
    • 18244428600 scopus 로고    scopus 로고
    • Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant
    • Bladé J, Samson D, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102(5): 1115-1123.
    • (1998) Br J Haematol , vol.102 , Issue.5 , pp. 1115-1123
    • Bladé, J.1    Samson, D.2    Reece, D.3
  • 25
    • 84877089105 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • Niesvizky R, Martin TG III, Bensinger WI, et al. Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res. 2013;19(8): 2248-2256.
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2248-2256
    • Niesvizky, R.1    Martin, T.G.2    Bensinger, W.I.3
  • 26
    • 84906043062 scopus 로고    scopus 로고
    • A phase I/II trial of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma: Final results of MTD expansion cohort [abstract]
    • Mikhael JR, Reeder CB, Libby EN, et al. A phase I/II trial of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma: final results of MTD expansion cohort [abstract]. Blood. 2013;122(21):3179.
    • (2013) Blood , vol.122 , Issue.21 , pp. 3179
    • Mikhael, J.R.1    Reeder, C.B.2    Libby, E.N.3
  • 27
    • 84905721292 scopus 로고    scopus 로고
    • Dose escalation phase 2 trial of carfilzomib combined with thalidomide and low-dose dexamethasone in newly diagnosed transplant eligible patients with multiple myeloma. A trial of the European Myeloma Network [abstract]
    • Sonneveld P, Asselberg-Hacker E, Zweegman S, et al. Dose escalation phase 2 trial of carfilzomib combined with thalidomide and low-dose dexamethasone in newly diagnosed, transplant eligible patients with multiple myeloma. A trial of the European Myeloma Network [abstract]. Blood. 2013;122(21):688.
    • (2013) Blood , vol.122 , Issue.21 , pp. 688
    • Sonneveld, P.1    Asselberg-Hacker, E.2    Zweegman, S.3
  • 28
    • 84906053160 scopus 로고    scopus 로고
    • A phase II study with carfilzomib, cyclophosphamide and dexamethasone (CCd) for newly diagnosed multiple myeloma [abstract]
    • Bringhen S, Cerrato C, Petrucci MT, et al. A phase II study with carfilzomib, cyclophosphamide and dexamethasone (CCd) for newly diagnosed multiple myeloma [abstract]. Blood. 2013;122(21): 685.
    • (2013) Blood , vol.122 , Issue.21 , pp. 685
    • Bringhen, S.1    Cerrato, C.2    Petrucci, M.T.3
  • 29
    • 84948972919 scopus 로고    scopus 로고
    • Phase 1/1b study of the efficacy and safety of the combination of panobinostat 1 carfilzomib in patients with relapsed and/or refractory multiple myeloma [abstract]
    • Abstract 4081
    • Shah JJ, Thomas SK, Weber DM, et al. Phase 1/1b study of the efficacy and safety of the combination of panobinostat 1 carfilzomib in patients with relapsed and/or refractory multiple myeloma [abstract]. Blood. 2012;120(21). Abstract 4081.
    • (2012) Blood , vol.120 , Issue.21
    • Shah, J.J.1    Thomas, S.K.2    Weber, D.M.3
  • 30
    • 84948956404 scopus 로고    scopus 로고
    • Phase I/II study of panobinostat and carfilzomib in patients (pts) with relapsed or refractory multiple myeloma (MM), interim phase i safety analysis [abstract]
    • Abstract 4048
    • Berdeja JG, Hart L, Lamar R, Murphy P, Morgan S, Flinn IW. Phase I/II study of panobinostat and carfilzomib in patients (pts) with relapsed or refractory multiple myeloma (MM), interim phase I safety analysis [abstract]. Blood. 2012;120(21). Abstract 4048.
    • (2012) Blood , vol.120 , Issue.21
    • Berdeja, J.G.1    Hart, L.2    Lamar, R.3    Murphy, P.4    Morgan, S.5    Flinn, I.W.6
  • 31
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study [published correction appears in Leukemia. 2012; 26(5): 1153]
    • Kumar SK, Lee JH, Lahuerta JJ, et al; International Myeloma Working Group. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study [published correction appears in Leukemia. 2012;26(5):1153]. Leukemia. 2012;26(1):149-157.
    • (2012) Leukemia , vol.26 , Issue.1 , pp. 149-157
    • Kumar, S.K.1    Lee, J.H.2    Lahuerta, J.J.3
  • 32
    • 78149468560 scopus 로고    scopus 로고
    • Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
    • Lacy MQ, Hayman SR, Gertz MA, et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia. 2010;24(11): 1934-1939.
    • (2010) Leukemia , vol.24 , Issue.11 , pp. 1934-1939
    • Lacy, M.Q.1    Hayman, S.R.2    Gertz, M.A.3
  • 33
    • 80052937408 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
    • Lacy MQ, Allred JB, Gertz MA, et al. Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease. Blood. 2011;118(11): 2970-2975.
    • (2011) Blood , vol.118 , Issue.11 , pp. 2970-2975
    • Lacy, M.Q.1    Allred, J.B.2    Gertz, M.A.3
  • 34
    • 84884702483 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): A randomised, open-label, phase 3 trial
    • San Miguel J, Weisel K, Moreau P, et al. Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial. Lancet Oncol. 2013;14(11): 1055-1066.
    • (2013) Lancet Oncol , vol.14 , Issue.11 , pp. 1055-1066
    • San Miguel, J.1    Weisel, K.2    Moreau, P.3
  • 35
    • 84897668614 scopus 로고    scopus 로고
    • Pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma (RRMM) with deletion (del)17p and/or translocation t(4;14) [abstract]
    • Leleu X, Karlin L, Macro M, et al. Pomalidomide plus low-dose dexamethasone in relapsed or refractory multiple myeloma (RRMM) with deletion (del)17p and/or translocation t(4;14) [abstract]. Blood. 2013;122(21):689.
    • (2013) Blood , vol.122 , Issue.21 , pp. 689
    • Leleu, X.1    Karlin, L.2    Macro, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.