Dual antiplatelet therapy in stroke and ICAS

Neurology

Volumn 85, Issue 13, 2015, Pages 1154-1162

  Liu, Liping ^a,b   Wong, Ka Sing Lawrence ^c   Leng, Xinyi ^c   Pu, Yuehua ^a,b   Wang, Yilong ^a,b   Jing, Jing ^a,b   Zou, Xinying ^a,b   Pan, Yuesong ^a,b   Wang, Anxin ^a,b   Meng, Xia ^a,b   Wang, Chunxue ^a,b   Zhao, Xingquan ^a,b   Soo, Yannie ^c   Claiborne Johnston, S ^d   Wang, Yongjun ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED PRACTICE; FEMALE; HEART INFARCTION; HIGH RISK PATIENT; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY (TOPIC); NEUROIMAGING; NEUROPROTECTION; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENCE RISK; RISK REDUCTION; SECONDARY ANALYSIS; STROKE PATIENT; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME; TREATMENT RESPONSE; ANALOGS AND DERIVATIVES; COMBINATION DRUG THERAPY; DOUBLE BLIND PROCEDURE; INTRACRANIAL ARTERIAL DISEASES; ISCHEMIC ATTACK, TRANSIENT; MIDDLE AGED; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; STENOSIS, OCCLUSION AND OBSTRUCTION; STROKE;

AGED; ASPIRIN; CONSTRICTION, PATHOLOGIC; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INTRACRANIAL ARTERIAL DISEASES; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RECURRENCE; STROKE; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84948978332     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001972     Document Type: Article

References (16)

1. Markus HS, Droste DW, Kaps M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) Trial. Circulation 2005;111:2233-2240.
2. Wong KS, Chen C, Fu J, et al. Clopidogrel Plus Aspirin Versus Aspirin Alone for Reducing Embolisation in Patients with Acute Symptomatic Cerebral or Carotid Artery Stenosis (CLAIR Study): a randomised, open-label, blinded-endpoint trial. Lancet Neurol 2010;9:489-497.
3. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11-19.
4. Feske SK. A little good. Circulation 2013;128:1598-1599.
5. Hankey GJ. Dual antiplatelet therapy in acute transient ischemic attack and minor stroke. N Engl J Med 2013; 369:82-83.
6. Wang Y, Johnston SC. Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high-risk patients with acute nondisabling cerebrovascular event. Am Heart J 2010;160:380-386.
7. An international randomized trial comparing four thrombo-lytic strategies for acute myocardial infarction. The GUSTO Investigators. N Engl J Med 1993;329:673-682.
8. Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MZ. A standardized method for measuring intra-cranial arterial stenosis. AJNR Am J Neuroradiol 2000;21: 643-646.
9. Wang Y, Zhao X, Liu L, et al. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke 2014;45:663-669.
10. Wong KS, Li H, Chan YL, et al. Use of transcranial Dop-pler ultrasound to predict outcome in patients with intra-cranial large-artery occlusive disease. Stroke 2000;31: 2641-2647.
11. Qureshi AI, Feldmann E, Gomez CR, et al. Intracranial atherosclerotic disease: an update. Ann Neurol 2009;66: 730-738.
12. Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrom-botic events. N Engl J Med 2006;354:1706-1717.
13. Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med 2012;367:817-825.
14. Wong KS, Wang Y, Leng X, et al. Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation 2013;128:1656-1666.
15. Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM. Fast Assessment of Stroke and Transient Ischaemic Attack to Prevent Early Recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007;6:961-969.
16. Johnston SC, Easton JD, Farrant M, et al. Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial: rationale and design. Int J Stroke 2013;8: 479-483.