Leflunomide induces pulmonary and hepatic CYP1A enzymes via aryl hydrocarbon receptor

Drug Metabolism and Disposition

Volumn 43, Issue 12, 2015, Pages 1966-1970

  Patel, Ananddeep ^a   Zhang, Shaojie ^a   Paramahamsa, Maturu ^a   Jiang, Weiwu ^a   Wang, Lihua ^a   Moorthy, Bhagavatula ^a   Shivanna, Binoy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN DEETHYLASE; HEPATIC CYTOCHROME P450 1A; LEFLUNOMIDE; LIVER ENZYME; MESSENGER RNA; PULMONARY CYTOCHROME P450 1A; UNCLASSIFIED DRUG; AHR PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYTOCHROME P450 INDUCER; ISOXAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; KNOCKOUT MOUSE; LIVER; LUNG; METABOLISM;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME INDUCERS; FEMALE; ISOXAZOLES; LIVER; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ARYL HYDROCARBON;

EID: 84948973359     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.066084     Document Type: Article

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