Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

PLoS Pathogens

Volumn 11, Issue 11, 2015, Pages

  Kim, Sang Hu ^a   Clark, Shawn T ^a   Surendra, Anuradha ^b   Copeland, Julia K ^b   Wang, Pauline W ^b,c   Ammar, Ron ^a   Collins, Cathy ^a   Tullis, D Elizabeth ^d   Nislow, Corey ^e   Hwang, David M ^a   Guttman, David S ^b,c   Cowen, Leah E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSOME RNA; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL REPRESSOR NRG1; UNCLASSIFIED DRUG; NEU DIFFERENTIATION FACTOR; NRG1 PROTEIN, HUMAN;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLUS; CANDIDA; CONTROLLED STUDY; CYSTIC FIBROSIS; DNA EXTRACTION; FUNGAL COLONIZATION; FUNGAL COMMUNITY; FUNGAL GENETICS; FUNGUS GROWTH; FUNGUS ISOLATION; GENOME ANALYSIS; MICROBIOME; NONHUMAN; PATHOGENICITY; QUANTITATIVE ANALYSIS; RNA SEQUENCE; SPUTUM EXAMINATION; VIRUS MORPHOGENESIS; ADAPTATION; ANTIFUNGAL RESISTANCE; FUNGUS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MICROFLORA; MUTATION; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SPUTUM;

ADAPTATION, BIOLOGICAL; CYSTIC FIBROSIS; DRUG RESISTANCE, FUNGAL; FUNGI; HUMANS; MICROBIOTA; MUTATION; NEUREGULIN-1; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SPUTUM;

EID: 84948957265     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005308     Document Type: Article

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