Expression, Regulation and the Role of SLC26 Cl-/HCO3- Exchangers in Kidney and Gastrointestinal Tract

Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family

Volumn , Issue , 2008, Pages 91-106

  Soleimani, Manoocher ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bicarbonate secretion; Chloride abosption; Chloride bicarbonate exchange; Duodenum; Kidney; NaCl absorption; Pancreatic duct; Stomach

Indexed keywords

EID: 84948769047     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0470029579.ch7     Document Type: Chapter

References (59)

1. Alper SL, Natale J, Gluck S, Lodish HF, Brown D 1989 Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H-ATPase. Proc Natl Acad Sci USA 86:5429-5433
2. Alpern RJ, Stone DK, Rector FC 1991 Jr. Renal acidification mechanisms. In: Brenner BM, Rector FC, Saunders WB Jr. (eds) The Kidney. WB Saunders Co, Philadelphia p 318-378
3. -exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct. J Am Soc Nephrol 15:2002-2011
4. Bissig M, Hagenbuch B, Stieger B, Koller T, Meier PJ 1994 Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem 269:3017-3021
5. Chernova MN, Jiang L, Shmukler BE et al 2003 Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol 549:3-19
6. Chernova MN, Jiang L, Friedman DJ 2005 Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem 280:8564-8580
7. Cox KH, Adair-Kirk TL, Cox JV 1996 Variant AE2 anion exchanger transcripts accumulate in multiple cell types in the chicken gastric epithelium. J Biol Chem 271:8895-8902
8. Coyle B, Reardon W, Herbrick J-A et al 1998 Molecular analysis of the PDS gene in Pendred syndrome (sensorineural hearing loss and goitre). Human Mol Gen 7:1105-1112
9. Curci S, Debellis L, Caroppo R, Fromter E 1994 Model of bicarbonate secretion by resting frog stomach fundus mucosa. I. Transepithelial measurements. Pfl uegers Arch 428:648-654
10. Engel E, Guth PH, Nishizaki Y, Kaunitz JD 1995 Barrier function of the gastric mucus gel. Am J Physiol 269:G994-999
11. Everett LA, Glaser B, Beck JC et al 1997 Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 17:411-422
12. Feldman M 1998 Gastric secretion: normal and abnormal. In: Feldman MD, Scharschmidt BF, Sleisenger MH, Klein SWB (eds) Gastrointestinal and liver disease: pathophysiology/ diagnosis/management (2nd ed), Saunders, Philadelphia p 587-603
13. -exchanger are achlorhydric. J Biol Chem 279:30531-30539
14. Greeley T, Shumaker H, Wang Z, Schweinfest CW, Soleimani M 2001 Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cell. Am J Physiol 281:G1301-1308
15. Hastabacka J, de la Chapelle A, Mahtani MM et al 1994 The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 78:1073-1087
16. Höglund P, Haila S, Socha J et al 1996 Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhea. Nat Genet 14:316-319
17. -exchange in rabbit, rat, and human duodenum. Gastroenterology 122:709-724
18. Jiang Z, Grichtchenko II, Boron WF, Aronson PS 2002 Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem 277:33963-33967
19. Jons T, Warrings B, Jons A, Drenckhahn D 1994 Basolateral localization of anion exchanger 2 (AE2) and actin in acid-secreting (parietal) cells of the human stomach. Histochemistry 102:255-263
20. Karet FE, Gainza FJ, Gyory AZ et al 1998 Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc Natl Acad Sci USA 95:6337-6342
21. Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS 2001 Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci USA 98:9425-9430
22. Ko SB, Shcheynikov N, Choi JY et al 2002 A molecular mechanism for aberrant CFTRdependent HCO(3)(-) transport in cystic fibrosis. EMBO J 21:5662-5672
23. Ko SB, Zeng W, Dorwart MR et al 2004 Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 6:343-350
24. Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J 2000 Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 70:102-112
25. Lohi H, Kujala M, Makela S et al 2002 Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. J Biol Chem 277:14246-14254
26. + exchanger. J Biol Chem 274:22855-22861
27. Mount DB, Romero MF 2004 The SLC26 gene family of multifunctional anion exchangers. Pfl ugers Arch 447:710-721
28. Paradiso AM, Townsley MC, Wenzl E, Machen TE 1989 Regulation of intracellular pH in resting and in stimulated parietal cells. Am J Physiol 257:C554-561
29. -exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol Gastrointest Liver Physiol 283:G1207-1216
30. -exchanger specific to gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 284:G1093-1103
31. -exchanger in rat kidney proximal tubule. Am J Physiol Cell Physiol 285:C608-617
32. -exchanger specific to intercalated cells of the outer medullary collecting duct. Am J Physiol Renal Physiol 286:F161-169
33. - exchanger SLC26A7 in the kidney medullary collecting duct of Brattleboro rats. Am J Physiol Renal Physiol Dec 13 [Epub ahead of print]
34. Phillipson M, Atuma C, Henriksnas J, Holm L 2002 The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 282:G211-219
35. Royaux IE, Wall SM, Karniski LP et al 2001 Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci USA 98:4221-4226
36. Schuster VL 1991 Cortical collecting duct bicarbonate secretion. Kid Int (suppl) 33:S47-50
37. Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS 1993 Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci USA 90:4166-4170
38. Scott DA, Karniski LP 2000 Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange. Am J Physiol Cell Physiol 278:C207-211
39. Seidler U, Carter K, Ito S, Silen W 1989 Effect of CO2 on pHi in rabbit parietal, chief, and surface cells. Am J Physiol 256(3 Pt 1):G466-475
40. Seidler U, Roithmaier S, Classen M, Silen W 1992 Infl uence of acid secretory state on Cl(-)-base and Na -Hexchange and pHi in isolated rabbit parietal cells. Am J Physiol 262(1 Pt 1):G81-91
41. -dependence of proton extrusion and Cl(-)-base exchange rates in isolated rabbit parietal cells. Am J Physiol 266(5 Pt 1):G759-776
42. Soleimani M 2001 Molecular physiology of the renal chloride-formate exchanger. Curr Opin Nephrol Hypertens 10:677-683
43. -exchanger in the kidney cortex. Am J Physiol 280:F356-364
44. Takeuchi K, Merhav A, Silen W 1982 Mechanism of luminal alkalinization by bullfrog fundic mucosa. Am J Physiol 243:G377-388
45. Tanphaichitr VS, Sumboonnanonda A, Ideguchi H et al 1998 Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A. J Clin Invest 102:2173-2179
46. Thomas HA, Machen TE 1991 Regulation of Cl/HCO3 exchange in gastric parietal cells. Cell Regul 2:727-737
47. -transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney. J Biol Chem 276:8180-8189
48. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP 2002 Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. Genomics 79:249-256
49. Vincourt JB, Jullien D, Amalric F, Girard JP 2003 Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. FASEB J 17:890-892
50. Wagner S, Vogel R, Lietzke R, Koob R, Drenckhahn D 1987 Immunochemical characterization of a band 3-like anion exchanger in collecting duct of human kidney. Am J Physiol 253:F213-221
51. -exchanger (Slc4a1). J Am Soc Nephrol 15:70A
52. Wang Z, Petrovic S, Mann E, Soleimani M 2002 Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol 282:G573-579
53. Wang Z, Wang T, Petrovic S et al 2005 Kidney and intestine transport defects in Slc26a6 null mice. Am J Physiol Cell Physiol 288:C957-965
54. -exchange activity in tracheal epithelial cells. Am J Physiol:Cell 279:62-70
55. Xie Q, Welch R, Mercado A, Romero MF, Mount DB 2002 Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol 283:F826-838
56. -exchanger in gastric surface mucous and duodenal villus cells. Am J Physiol 285:G1225-1234
57. -exchanger SLC26A7 is localized in recycling endosomes in kidney medullary collecting cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. J Am Soc Neph, in press
58. -exchange and is inhibited by NH4 Am J Physiol: Cell Physiol 289:C493-505
59. Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P 2000 Prestin is the motor protein of cochlear outer hair cells. Nature 405:149-155