Safety, pharmacokinetics and efficacy findings in an open-label, single-arm study of weekly paclitaxel plus lapatinib as first-line therapy for Japanese women with HER2-positive metastatic breast cancer

International Journal of Clinical Oncology

Volumn 20, Issue 6, 2015, Pages 1102-1109

  Inoue, Kenichi ^a   Kuroi, Katsumasa ^b   Shimizu, Satoru ^c   Rai, Yoshiaki ^d   Aogi, Kenjiro ^e   Masuda, Norikazu ^f   Nakayama, Takahiro ^g,h   Iwata, Hiroji ⁱ   Nishimura, Yuichiro ^j   Armour, Alison ^k   Sasaki, Yasutsuna ^l,m  

^a SAITAMA CANCER CENTER   (Japan)

^b TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^c KANAGAWA CANCER CENTER   (Japan)

^d SAGARA HOSPITAL   (Japan)

^e NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

^f OSAKA NATIONAL HOSPITAL   (Japan)

^g OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

ⁱ AICHI CANCER CENTER HOSPITAL   (Japan)

^j Development and Medical Affairs Division   (Japan)

^k GLAXOSMITHKLINE   (United States)

^l SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

^m SHOWA UNIVERSITY HOSPITAL   (Japan)

more..

Author keywords

HER2; Lapatinib; Metastatic breast cancer; Paclitaxel

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEMOGLOBIN; LAPATINIB; PACLITAXEL; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE;

ACNE; ADULT; AGED; ALOPECIA; AREA UNDER THE CURVE; ARTICLE; BREAST METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CLINICAL ARTICLE; DECREASED APPETITE; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG EXPOSURE; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; EYELID ERYTHEMA; FATIGUE; FEMALE; HUMAN; HUMAN TISSUE; JAPANESE (PEOPLE); LEUKOPENIA; LYMPHOCYTOPENIA; MAXIMUM PLASMA CONCENTRATION; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NAIL DISEASE; NEUROTOXICITY; NEUTROPENIA; OPEN STUDY; OVERALL SURVIVAL; PARONYCHIA; PERIPHERAL NEUROPATHY; PHARMACOKINETIC PARAMETERS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RASH; REPEATED DRUG DOSE; RHINOPHARYNGITIS; SENSORY NEUROPATHY; SIDE EFFECT; STOMATITIS; VOMITING; ANTAGONISTS AND INHIBITORS; BLOOD; BREAST NEOPLASMS; CHEMICALLY INDUCED; CHEMISTRY; CLINICAL TRIAL; JAPAN; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; SURVIVAL RATE;

AGED; ALOPECIA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AREA UNDER CURVE; BREAST NEOPLASMS; DIARRHEA; FEMALE; HEMOGLOBINS; HUMANS; JAPAN; MIDDLE AGED; NEOPLASM METASTASIS; PACLITAXEL; QUINAZOLINES; RECEPTOR, ERBB-2; SURVIVAL RATE;

EID: 84948719874     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-015-0832-5     Document Type: Article

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