Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking

European Radiology

Volumn 26, Issue 1, 2016, Pages 15-24

  Araki, Tetsuro ^a,b   Nishino, Mizuki ^a   Gao, Wei ^c   Dupuis, Josée ^c,d   Hunninghake, Gary M ^a   Murakami, Takamichi ^b   Washko, George R ^a   O’Connor, George T ^d,e   Hatabu, Hiroto ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Department of Radiology ^*  (Japan)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adult; Body mass index; Computed tomography; Smoking; Thymus gland

Indexed keywords

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; COHORT ANALYSIS; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; FAT CONTENT; FEMALE; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORPHOLOGY; PRIORITY JOURNAL; RADIATION ATTENUATION; SCORING SYSTEM; SEX DIFFERENCE; SMOKING; SOFT TISSUE; THYMUS; AGE; AGED; ANATOMY AND HISTOLOGY; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; MULTICENTER STUDY; PATHOLOGY; SEXUAL DEVELOPMENT; X-RAY COMPUTED TOMOGRAPHY;

ADULT; AGE FACTORS; AGED; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; SEX CHARACTERISTICS; SMOKING; THYMUS GLAND; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84948717821     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-015-3796-y     Document Type: Article

References (26)

1. Nishino M, Ashiku SK, Kocher ON, Thurer RL, Boiselle PM, Hatabu H (2006) The thymus: a comprehensive review. Radiographics 26(2):335–48
2. Suster S, Rosai J (1990) Histology of the normal thymus. Am J Surg Pathol 14(3):284–303
3. Baron R, Lee J, Sagel S, Peterson R (1982) Computed tomography of the normal thymus. Radiology 142(1):121–5
4. Francis I, Glazer G, Bookstein F, Gross B (1985) The thymus: reexamination of age-related changes in size and shape. Am J Roentgenol 145(2):249–54
5. Simanovsky N, Hiller N, Loubashevsky N, Rozovsky K (2012) Normal CT characteristics of the thymus in adults. Eur J Radiol 81(11):3581–6
6. Ackman JB, Kovacina B, Carter BW, Wu CC, Sharma A, Shepard JA et al (2013) Sex difference in normal thymic appearance in adults 20–30 years of age. Radiology 268(1):245–53
7. Henschke CI, Lee IJ, Wu N, Farooqi A, Khan A, Yankelevitz D et al (2006) CT screening for lung cancer: prevalence and incidence of mediastinal masses. Radiology 239(2):586–90
8. Priola AM, Priola SM, Giaj-Levra M, Basso E, Veltri A, Fava C et al (2013) Clinical implications and added costs of incidental findings in an early detection study of lung cancer by using low-dose spiral computed tomography. Clin Lung Cancer 14(2):139–48
9. Araki T, Nishino M, Gao W, Dupuis J, Washko GR, Hunninghake GM et al (2015) Anterior mediastinal masses in the Framingham heart study: prevalence and CT image characteristics. Eur J Radiol Open 2:26–31
10. Mendis S (2010) The contribution of the Framingham heart study to the prevention of cardiovascular disease: a global perspective. Prog Cardiovasc Dis 53(1):10–4
11. Sopori M (2002) Effects of cigarette smoke on the immune system. Nat Rev Immunol 2(5):372–7
12. Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M (2014) Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. Acad Radiol 21(6):733–42
13. Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M (2014) Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. AJR Am J Roentgenol 202(3):471–8
14. Jin GY, Lynch D, Chawla A, Garg K, Tammemagi MC, Sahin H et al (2013) Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate. Radiology 268(2):563–71
15. Kundel HL, Polansky M (2003) Measurement of observer agreement. Radiology 228(2):303–8
16. Uh HW, Wijk HJ, Houwing-Duistermaat JJ (2009) Testing for genetic association taking into account phenotypic information of relatives. BMC Proc 3(Suppl 7):S123
17. Priola AM, Priola SM, Ciccone G, Evangelista A, Cataldi A, Gned D et al (2015) Differentiation of rebound and lymphoid thymic hyperplasia from anterior mediastinal tumors with dual-echo chemical-shift MR imaging in adulthood: reliability of the chemical-shift ratio and signal intensity index. Radiology 274(1):238–49
18. Tibbetts TA, DeMayo F, Rich S, Conneely OM, O’Malley BW (1999) Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc Natl Acad Sci U S A 96(21):12021–6
19. Zeyrek D, Ozturk E, Ozturk A, Cakmak A (2008) Decreased thymus size in full-term newborn infants of smoking mothers. Med Sci Monit Int Med J Exp Clin Res 14(8):CR423–6
20. Yang H, Youm YH, Vandanmagsar B, Rood J, Kumar KG, Butler AA et al (2009) Obesity accelerates thymic aging. Blood 114(18):3803–12
21. Gulvady AA, Ciolino HP, Cabrera RM, Jolly CA (2013) Resveratrol inhibits the deleterious effects of diet-induced obesity on thymic function. J Nutr Biochem 24(9):1625–33
22. Yoshida K, Nakashima E, Kubo Y, Yamaoka M, Kajimura J, Kyoizumi S et al (2014) Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors. PLoS One 9(3):e91985
23. Moore AV, Korobkin M, Olanow W, Heaston DK, Ram P, Dunnick N et al (1983) Age-related changes in the thymus gland: CT-pathologic correlation. Am J Roentgenol 141(2):241–6
24. Niendorf ER, Parker JA, Yechoor V, Garber JR, Boiselle PM (2005) Thymic hyperplasia in thyroid cancer patients. J Thorac Imaging 20(1):1–4
25. Nishihara M (1987) [CT of the thymus–I. CT image of the normal thymus]. Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiol 47(6):799–803 (In Japanese)
26. Shimosato Y, Mukai K, Matsuno Y (2010) Tumors of the mediastinum; AFIP Atlas of tumor pathology 4th series fascicle 11. ARP PRESS, Silver Spring