메뉴 건너뛰기




Volumn 35, Issue 12, 2015, Pages 2021-2031

Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice

Author keywords

brain ischemia; endothelial endocytosis; tissue type plasminogen activator; vascular endothelial growth factor; vascular permeability

Indexed keywords

ALTEPLASE; LOW DENSITY LIPOPROTEIN RECEPTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; BOVINE SERUM ALBUMIN; FIBRINOLYTIC AGENT; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KDR PROTEIN, MOUSE; LIPOPROTEIN RECEPTOR; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; VASCULOTROPIN A;

EID: 84948715895     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.167     Document Type: Article
Times cited : (31)

References (40)
  • 1
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tpa) increases neuronal damage after focal cerebral ischemia in wild-Type and tpa-deficient mice
    • Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-Type and tPA-deficient mice. Nat Med. 1998; 4: 228-231.
    • (1998) Nat Med , vol.4 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3    Stieg, P.E.4    Soriano, S.G.5    Lipton, S.A.6
  • 2
    • 0034746189 scopus 로고    scopus 로고
    • The proteolytic activity of tissue-plasminogen activator enhances nmda receptormediated signaling
    • Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptormediated signaling. Nat Med. 2001; 7: 59-64.
    • (2001) Nat Med , vol.7 , pp. 59-64
    • Nicole, O.1    Docagne, F.2    Ali, C.3    Margaill, I.4    Carmeliet, P.5    MacKenzie, E.T.6
  • 3
    • 0033545965 scopus 로고    scopus 로고
    • Role of plasminogen system components in focal cerebral ischemic infarction: A gene targeting and gene transfer study in mice
    • Nagai N, De Mol M, Lijnen HR, Carmeliet P, Collen D. Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation. 1999; 99: 2440-2444.
    • (1999) Circulation , vol.99 , pp. 2440-2444
    • Nagai, N.1    De Mol, M.2    Lijnen, H.R.3    Carmeliet, P.4    Collen, D.5
  • 4
    • 70350462242 scopus 로고    scopus 로고
    • Tissue-Type plasminogen activator (t-pa) induces stromelysin-1 (mmp-3) in endothelial cells through activation of lipoprotein receptor-related protein
    • Suzuki Y, Nagai N, Yamakawa K, Kawakami J, Lijnen HR, Umemura K. Tissue-Type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. Blood. 2009; 114: 3352-3358.
    • (2009) Blood , vol.114 , pp. 3352-3358
    • Suzuki, Y.1    Nagai, N.2    Yamakawa, K.3    Kawakami, J.4    Lijnen, H.R.5    Umemura, K.6
  • 5
    • 20944452152 scopus 로고    scopus 로고
    • Tissue-Type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis
    • Benchenane K, Berezowski V, Ali C, Fernández-Monreal M, López-Atalaya JP, Brillault J, et al. Tissue-Type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation. 2005; 111: 2241-2249.
    • (2005) Circulation , vol.111 , pp. 2241-2249
    • Benchenane, K.1    Berezowski, V.2    Ali, C.3    Fernández-Monreal, M.4    López-Atalaya, J.P.5    Brillault, J.6
  • 6
    • 46749118298 scopus 로고    scopus 로고
    • Activation of pdgfcc by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
    • Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, et al. Activation of PDGFCC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med. 2008; 14: 731-737.
    • (2008) Nat Med , vol.14 , pp. 731-737
    • Su, E.J.1    Fredriksson, L.2    Geyer, M.3    Folestad, E.4    Cale, J.5    Andrae, J.6
  • 7
    • 0345824713 scopus 로고    scopus 로고
    • Tissuetype plasminogen activator induces opening of the blood-brain barrier via the ldl receptor-related protein
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissuetype plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest. 2003; 112: 1533-1540.
    • (2003) J Clin Invest , vol.112 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 8
    • 84861213311 scopus 로고    scopus 로고
    • Plasmin-mediated activation of the rho kinase pathway in astrocytes
    • Niego B, Freeman R, Puschmann TB, Turnley AM, Medcalf RL. Plasmin-mediated activation of the Rho kinase pathway in astrocytes. Blood. 2012; 119: 4752-4761.
    • (2012) Blood , vol.119 , pp. 4752-4761
    • Niego, B.1    Freeman, R.2    Puschmann, T.B.3    Turnley, A.M.4    Medcalf, R.L.5
  • 9
    • 84905513820 scopus 로고    scopus 로고
    • Plasmin-dependent modulation of the blood-brain barrier: A major consideration during tpa-induced thrombolysis?
    • Niego B, Medcalf RL. Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?. J Cereb Blood Flow Metab. 2014; 34: 1283-1296.
    • (2014) J Cereb Blood Flow Metab , vol.34 , pp. 1283-1296
    • Niego, B.1    Medcalf, R.L.2
  • 10
    • 0001665337 scopus 로고
    • Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the ldl-receptor suggest a physiological role as lipoprotein receptor
    • Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988; 7: 4119-4127.
    • (1988) EMBO J , vol.7 , pp. 4119-4127
    • Herz, J.1    Hamann, U.2    Rogne, S.3    Myklebost, O.4    Gausepohl, H.5    Stanley, K.K.6
  • 11
    • 0026756089 scopus 로고
    • Low density lipoprotein receptorrelated protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissuetype plasminogen activator
    • Bu G, Williams S, Strickland DK, Schwartz AL. Low density lipoprotein receptorrelated protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissuetype plasminogen activator. Proc Natl Acad Sci USA. 1992; 89: 7427-7431.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7427-7431
    • Bu, G.1    Williams, S.2    Strickland, D.K.3    Schwartz, A.L.4
  • 12
    • 33947543221 scopus 로고    scopus 로고
    • Recombinant desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects
    • López-Atalaya JP, Roussel BD, Ali C, Maubert E, Petersen KU, Berezowski Velli R, et al. Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects. Stroke. 2007; 38: 1036-1043.
    • (2007) Stroke , vol.38 , pp. 1036-1043
    • López-Atalaya, J.P.1    Roussel, B.D.2    Ali, C.3    Maubert, E.4    Petersen, K.U.5    Berezowski Velli, R.6
  • 13
    • 17644364387 scopus 로고    scopus 로고
    • Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions
    • Roux F, Couraud PO. Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions. Cell Mol Neurobiol. 2005; 25: 41-58.
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 41-58
    • Roux, F.1    Couraud, P.O.2
  • 14
    • 0036354737 scopus 로고    scopus 로고
    • Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves vegf-mediated changes in the expression of zonula occludens-1
    • Fischer S, Wobben M, Marti HH, Renz D, Schaper W. Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1. Microvasc Res. 2002; 63: 70-80.
    • (2002) Microvasc Res , vol.63 , pp. 70-80
    • Fischer, S.1    Wobben, M.2    Marti, H.H.3    Renz, D.4    Schaper, W.5
  • 15
    • 84862691108 scopus 로고    scopus 로고
    • Regulation of vegf signaling by membrane traffic
    • Horowitz A, Seerapu HR. Regulation of VEGF signaling by membrane traffic. Cell Sig. 2012; 24: 1810-1820.
    • (2012) Cell Sig , vol.24 , pp. 1810-1820
    • Horowitz, A.1    Seerapu, H.R.2
  • 16
    • 20444477494 scopus 로고    scopus 로고
    • Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats
    • Abumiya T, Yokota C, Kuge Y, Minematsu K. Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats. Brain Res. 2005; 1049: 95-103.
    • (2005) Brain Res , vol.1049 , pp. 95-103
    • Abumiya, T.1    Yokota, C.2    Kuge, Y.3    Minematsu, K.4
  • 17
    • 0029598486 scopus 로고
    • Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
    • Namiki A, Brogi E, Kearney M, Kim EA, Wu T, Couffinhal T, et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem. 1995; 270: 31189-31195.
    • (1995) J Biol Chem , vol.270 , pp. 31189-31195
    • Namiki, A.1    Brogi, E.2    Kearney, M.3    Kim, E.A.4    Wu, T.5    Couffinhal, T.6
  • 18
    • 76049100577 scopus 로고    scopus 로고
    • Hif-1: Upstream and downstream of cancer metabolism
    • Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev. 2010; 20: 51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 19
    • 77951698149 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
    • Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res. 2010; 86: 236-242.
    • (2010) Cardiovasc Res , vol.86 , pp. 236-242
    • Rey, S.1    Semenza, G.L.2
  • 20
    • 25144460038 scopus 로고    scopus 로고
    • Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice
    • Nagai N, Suzuki Y, Van Hoef B, Lijnen HR, Collen D. Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice. J Thromb Haemost. 2005; 3: 1379-1384.
    • (2005) J Thromb Haemost , vol.3 , pp. 1379-1384
    • Nagai, N.1    Suzuki, Y.2    Van Hoef, B.3    Lijnen, H.R.4    Collen, D.5
  • 22
    • 84864711123 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice
    • Ho VC, Duan LJ, Cronin C, Liang BT, Fong GH. Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice. Circulation. 2012; 126: 741-752.
    • (2012) Circulation , vol.126 , pp. 741-752
    • Ho, V.C.1    Duan, L.J.2    Cronin, C.3    Liang, B.T.4    Fong, G.H.5
  • 23
    • 80255137111 scopus 로고    scopus 로고
    • Brain accumulation of sunitinib is restricted by p-glycoprotein (abcb1) and breast cancer resistance protein (abcg2) and can be enhanced by oral elacridar and sunitinib coadministration
    • Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, et al. Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer. 2012; 130: 223-233.
    • (2012) Int J Cancer , vol.130 , pp. 223-233
    • Tang, S.C.1    Lagas, J.S.2    Lankheet, N.A.3    Poller, B.4    Hillebrand, M.J.5    Rosing, H.6
  • 24
    • 0037008460 scopus 로고    scopus 로고
    • Sm-20220, a na (+)/h(+) exchanger inhibitor: Effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model
    • Suzuki Y, Matsumoto Y, Ikeda Y, Kondo K, Ohashi N, Umemura K. SM-20220, a Na (+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res. 2002; 945: 242-248.
    • (2002) Brain Res , vol.945 , pp. 242-248
    • Suzuki, Y.1    Matsumoto, Y.2    Ikeda, Y.3    Kondo, K.4    Ohashi, N.5    Umemura, K.6
  • 25
    • 78651409313 scopus 로고    scopus 로고
    • Remodeling of ve-cadherin junctions by the human herpes virus 8 g-protein coupled receptor
    • Dwyer J, Le Guelte A, Galan Moya EM, Sumbal M, Carlotti A, Douguet L, et al. Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor. Oncogene. 2011; 30: 190-200.
    • (2011) Oncogene , vol.30 , pp. 190-200
    • Dwyer, J.1    Le Guelte, A.2    Galan Moya, E.M.3    Sumbal, M.4    Carlotti, A.5    Douguet, L.6
  • 26
    • 33747379469 scopus 로고    scopus 로고
    • Phenanthroquinolizidine alkaloids from the roots of boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in ags human gastric cancer cells
    • Cai XF, Jin X, Lee D, Yang YT, Lee K, Hong YS, Lee JH, Lee JJ. Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. J Nat Prod. 2006; 69: 1095-1097.
    • (2006) J Nat Prod , vol.69 , pp. 1095-1097
    • Cai, X.F.1    Jin, X.2    Lee, D.3    Yang, Y.T.4    Lee, K.5    Hong, Y.S.6    Lee, J.H.7    Lee, J.J.8
  • 28
    • 84455169930 scopus 로고    scopus 로고
    • Chronic deficiency of nitric oxide affects hypoxia inducible factor-1a (hif-1a) stability and migration in human endothelial cells
    • Cattaneo MG, Cappellini E, Benfante R, Ragni M, Omodeo-Salè F, Nisoli E, et al. Chronic deficiency of nitric oxide affects hypoxia inducible factor-1a (HIF-1a) stability and migration in human endothelial cells. PLoS One. 2011; 6: e29680.
    • (2011) PLoS One , vol.6 , pp. e29680
    • Cattaneo, M.G.1    Cappellini, E.2    Benfante, R.3    Ragni, M.4    Omodeo-Salè, F.5    Nisoli, E.6
  • 29
    • 80051698338 scopus 로고    scopus 로고
    • Gep100-Arf6-Amap1-cortactin pathway frequently used in cancer invasion is activated by vegfr2 to promote angiogenesis
    • Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, et al. GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS One. 2011; 6: e23359.
    • (2011) PLoS One , vol.6 , pp. e23359
    • Hashimoto, A.1    Hashimoto, S.2    Ando, R.3    Noda, K.4    Ogawa, E.5    Kotani, H.6
  • 30
    • 11144305139 scopus 로고    scopus 로고
    • Cyclic amp potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an epac-rap1 signaling pathway
    • Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, et al. Cyclic AMP Potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol. 2005; 25: 136-146.
    • (2005) Mol Cell Biol , vol.25 , pp. 136-146
    • Fukuhara, S.1    Sakurai, A.2    Sano, H.3    Yamagishi, A.4    Somekawa, S.5    Takakura, N.6
  • 32
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med. 1990; 172: 1535-1545.
    • (1990) J Exp Med , vol.172 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.3    Brett, J.4    Wang, F.5    Familletti, P.C.6
  • 33
    • 33747165872 scopus 로고    scopus 로고
    • Vascular endothelial cadherin controls vegfr-2 internalization and signaling from intracellular compartments
    • Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol. 2006; 174: 593-604.
    • (2006) J Cell Biol , vol.174 , pp. 593-604
    • Lampugnani, M.G.1    Orsenigo, F.2    Gagliani, M.C.3    Tacchetti, C.4    Dejana, E.5
  • 34
    • 50349092250 scopus 로고    scopus 로고
    • Ldl receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies
    • Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev. 2008; 88: 887-918.
    • (2008) Physiol Rev , vol.88 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 35
    • 0028024011 scopus 로고
    • Characterization of the murine plasma fibrinolytic system
    • Lijnen HR, van Hoef B, Beelen V, Collen D. Characterization of the murine plasma fibrinolytic system. Eur J Biochem. 1994; 224: 863-871.
    • (1994) Eur J Biochem , vol.224 , pp. 863-871
    • Lijnen, H.R.1    Van Hoef, B.2    Beelen, V.3    Collen, D.4
  • 36
    • 13244271945 scopus 로고    scopus 로고
    • Comparative effects of microplasmin and tissue-Type plasminogen activator (tpa) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice
    • Suzuki Y, Nagai N, Collen D. Comparative effects of microplasmin and tissue-Type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice. J Thromb Haemost. 2004; 2: 1617-1621.
    • (2004) J Thromb Haemost , vol.2 , pp. 1617-1621
    • Suzuki, Y.1    Nagai, N.2    Collen, D.3
  • 37
    • 0023934705 scopus 로고
    • Laboratory monitoring of hemostasis during thrombolytic therapy with recombinant human tissue-Type plasminogen activator
    • Garabedian HD, Gold HK, Leinbach RC, Yasuda T, Johns JA, Thornton D, et al. Laboratory monitoring of hemostasis during thrombolytic therapy with recombinant human tissue-Type plasminogen activator. Thromb Res. 1988; 50: 121-133.
    • (1988) Thromb Res , vol.50 , pp. 121-133
    • Garabedian, H.D.1    Gold, H.K.2    Leinbach, R.C.3    Yasuda, T.4    Johns, J.A.5    Thornton, D.6
  • 38
    • 34447633015 scopus 로고    scopus 로고
    • Stromelysin-1 (mmp-3) is critical for intracranial bleeding after t-pa treatment of stroke in mice
    • Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR. Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. J Thromb Haemost. 2007; 5: 1732-1739.
    • (2007) J Thromb Haemost , vol.5 , pp. 1732-1739
    • Suzuki, Y.1    Nagai, N.2    Umemura, K.3    Collen, D.4    Lijnen, H.R.5
  • 39
    • 80052955742 scopus 로고    scopus 로고
    • Surface-retained tpa is essential for effective fibrinolysis on vascular endothelial cells
    • Suzuki Y, Yasui H, Brzoska T, Mogami H, Urano T. Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells. Blood. 2011; 118: 3182-3185.
    • (2011) Blood , vol.118 , pp. 3182-3185
    • Suzuki, Y.1    Yasui, H.2    Brzoska, T.3    Mogami, H.4    Urano, T.5
  • 40
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014; 509: 507-511.
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1    Lacoste, B.2    Kur, E.3    Andreone, B.J.4    Mayshar, Y.5    Yan, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.