Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs

Journal of Clinical Epidemiology

Volumn 68, Issue 12, 2015, Pages 1504-1511

  Kahan, Brennan C ^a   Harhay, Michael O ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Center effects; Covariate adjustment; Generalized estimating equations; Multicenter trial; Random effects models; Randomized controlled trial

Indexed keywords

GENERALIZED ESTIMATING EQUATION; HUMAN; MEDICAL LITERATURE; MULTICENTER STUDY (TOPIC); OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RANDOM EFFECTS MODEL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STATISTICAL ANALYSIS; SURVIVAL; INFORMATION PROCESSING; PUBLICATION; SAMPLE SIZE; STATISTICAL BIAS; STATISTICAL MODEL; STATISTICS; STATISTICS AND NUMERICAL DATA;

BIAS (EPIDEMIOLOGY); DATA COLLECTION; DATA INTERPRETATION, STATISTICAL; HUMANS; MODELS, STATISTICAL; MULTICENTER STUDIES AS TOPIC; PATIENT OUTCOME ASSESSMENT; PERIODICALS AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SAMPLE SIZE; STATISTICS AS TOPIC;

EID: 84948714618     PISSN: 08954356     EISSN: 18785921     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2015.03.016     Document Type: Review

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