메뉴 건너뛰기




Volumn 18, Issue , 2015, Pages 32-38

Bisphosphonate drug holidays-when, why and for how long?

Author keywords

Alendronate; Atypical Fractures; Bisphosphonates; Drug Holiday; Risedronate; Zoledronate

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB; RISEDRONIC ACID; ZOLEDRONIC ACID; BONE DENSITY CONSERVATION AGENT;

EID: 84948582201     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.3109/13697137.2015.1099092     Document Type: Article
Times cited : (24)

References (44)
  • 1
    • 79952394479 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis
    • Watts NB, Bilezikian JP, Camacho PM., et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract 2010; 16 (Suppl 3): 1-37
    • (2010) Endocr Pract , vol.16 , pp. 1-37
    • Watts, N.B.1    Bilezikian, J.P.2    Camacho, P.M.3
  • 2
    • 84863587177 scopus 로고    scopus 로고
    • Benefits and risks of bisphosphonate therapy for osteoporosis
    • Khosla S, Bilezikian JP, Dempster DW., et al. Benefits and risks of bisphosphonate therapy for osteoporosis. J Clin Endocrinol Metab 2012; 97: 2272-82
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2272-2282
    • Khosla, S.1    Bilezikian, J.P.2    Dempster, D.W.3
  • 3
    • 78751701571 scopus 로고    scopus 로고
    • The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebral-nonhip fractures in osteoporosis: A network meta-analysis
    • Jansen JP, Bergman GJ, Huels J, Olson M. The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebral-nonhip fractures in osteoporosis: a network meta-analysis. Semin Arthritis Rheum 2011; 40: 275-84
    • (2011) Semin Arthritis Rheum , vol.40 , pp. 275-284
    • Jansen, J.P.1    Bergman, G.J.2    Huels, J.3    Olson, M.4
  • 4
    • 84938994855 scopus 로고    scopus 로고
    • Efficacy of bisphosphonates against osteoporosis in adult men: A meta-analysis of randomized controlled trials
    • Chen L, Wang G, Zheng F, Zhao H, Li H. Efficacy of bisphosphonates against osteoporosis in adult men: a meta-analysis of randomized controlled trials. Osteoporos Int 2015; 26: 2355-63
    • (2015) Osteoporos Int , vol.26 , pp. 2355-2363
    • Chen, L.1    Wang, G.2    Zheng, F.3    Zhao, H.4    Li, H.5
  • 5
    • 37349075476 scopus 로고    scopus 로고
    • The cost-effectiveness of alendronate in the management of osteoporosis
    • Kanis JA, Adams J, Borgström F., et al. The cost-effectiveness of alendronate in the management of osteoporosis. Bone 2008; 42: 4-15
    • (2008) Bone , vol.42 , pp. 4-15
    • Kanis, J.A.1    Adams, J.2    Borgström, F.3
  • 7
    • 43049109229 scopus 로고    scopus 로고
    • Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy
    • Russell RG, Watts NB, Ebetino FH, Rogers MJ. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 2008; 19: 733-59
    • (2008) Osteoporos Int , vol.19 , pp. 733-759
    • Russell, R.G.1    Watts, N.B.2    Ebetino, F.H.3    Rogers, M.J.4
  • 8
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial
    • Miller PD, Bolognese MA, Lewiecki EM., et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone 2008; 43: 222-9
    • (2008) Bone , vol.43 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3
  • 9
    • 0037016032 scopus 로고    scopus 로고
    • Significant differential effects of alendronate, estrogen, or combination therapy on the rate of bone loss after discontinuation of treatment of postmenopausal osteoporosis A randomized, double-blind, placebo-controlled trial
    • Greenspan SL, Emkey RD, Bone HG., et al. Significant differential effects of alendronate, estrogen, or combination therapy on the rate of bone loss after discontinuation of treatment of postmenopausal osteoporosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2002; 137: 875-83
    • (2002) Ann Intern Med , vol.137 , pp. 875-883
    • Greenspan, S.L.1    Emkey, R.D.2    Bone, H.G.3
  • 10
    • 84919934170 scopus 로고    scopus 로고
    • Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus
    • International Task Force on Osteonecrosis of the Jaw
    • Khan AA, Morrison A, Hanley DA, et al.; International Task Force on Osteonecrosis of the Jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 2015; 30: 3-23
    • (2015) J Bone Miner Res , vol.30 , pp. 3-23
    • Khan, A.A.1    Morrison, A.2    Hanley, D.A.3
  • 11
    • 47349120782 scopus 로고    scopus 로고
    • Canadian consensus practice guidelines for bisphosphonate associated osteonecrosis of the jaw
    • Canadian Association of Oral and Maxillofacial Surgeons
    • Khan AA, Sándor GK, Dore E, et al.; Canadian Association of Oral and Maxillofacial Surgeons. Canadian consensus practice guidelines for bisphosphonate associated osteonecrosis of the jaw. J Rheumatol 2008; 35: 1391-7
    • (2008) J Rheumatol , vol.35 , pp. 1391-1397
    • Khan, A.A.1    Sándor, G.K.2    Dore, E.3
  • 12
    • 33847113863 scopus 로고    scopus 로고
    • Bisphosphonate-associated osteonecrosis of the jaws
    • Goss AN. Bisphosphonate-associated osteonecrosis of the jaws. Climacteric 2007; 10: 5-8
    • (2007) Climacteric , vol.10 , pp. 5-8
    • Goss, A.N.1
  • 13
    • 79954610809 scopus 로고    scopus 로고
    • Risk factors for osteonecrosis of the jaws: A case-control study from the CONDOR dental PBRN
    • Barasch A, Cunha-Cruz J, Curro FA., et al. Risk factors for osteonecrosis of the jaws: a case-control study from the CONDOR dental PBRN. J Dent Res 2011; 90: 439-44
    • (2011) J Dent Res , vol.90 , pp. 439-444
    • Barasch, A.1    Cunha-Cruz, J.2    Curro, F.A.3
  • 14
    • 44449153039 scopus 로고    scopus 로고
    • Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates
    • Hoff AO, Toth BB, Altundag K., et al. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 2008; 23: 826-36
    • (2008) J Bone Miner Res , vol.23 , pp. 826-836
    • Hoff, A.O.1    Toth, B.B.2    Altundag, K.3
  • 15
    • 34848819692 scopus 로고    scopus 로고
    • A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: Prevalence, risk factors, and clinical characteristics
    • Pazianas M, Miller P, Blumentals WA, Bernal M, Kothawala P. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin Ther 2007; 29: 1548-58
    • (2007) Clin Ther , vol.29 , pp. 1548-1558
    • Pazianas, M.1    Miller, P.2    Blumentals, W.A.3    Bernal, M.4    Kothawala, P.5
  • 16
    • 84856608613 scopus 로고    scopus 로고
    • Epidemiology and pathogenesis of osteonecrosis of the jaw
    • Reid IR, Cornish J. Epidemiology and pathogenesis of osteonecrosis of the jaw. Nat Rev Rheumatol 2011; 8: 90-6
    • (2011) Nat Rev Rheumatol , vol.8 , pp. 90-96
    • Reid, I.R.1    Cornish, J.2
  • 17
    • 70449535711 scopus 로고    scopus 로고
    • Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats
    • Hikita H, Miyazawa K, Tabuchi M, Kimura M, Goto S. Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats. J Bone Miner Metab 2009; 27: 663-72
    • (2009) J Bone Miner Metab , vol.27 , pp. 663-672
    • Hikita, H.1    Miyazawa, K.2    Tabuchi, M.3    Kimura, M.4    Goto, S.5
  • 18
    • 84891034178 scopus 로고    scopus 로고
    • Atypical subtrochanteric and diaphyseal femoral fractures: A second report of a task force of the American Society for Bone and Mineral Research
    • Shane E, Burr D, Ebeling PR., et al. Atypical subtrochanteric and diaphyseal femoral fractures: a second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2014; 29: 1-23
    • (2014) J Bone Miner Res , vol.29 , pp. 1-23
    • Shane, E.1    Burr, D.2    Ebeling, P.R.3
  • 19
    • 79955722153 scopus 로고    scopus 로고
    • Bisphosphonate use and atypical fractures of the femoral shaft
    • Schilcher J, Michaëlsson K, Aspenberg P. Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 2011; 364: 1728-37
    • (2011) N Engl J Med , vol.364 , pp. 1728-1737
    • Schilcher, J.1    Michaëlsson, K.2    Aspenberg, P.3
  • 20
    • 84878164987 scopus 로고    scopus 로고
    • Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: A systematic review and meta-analysis
    • Gedmintas L, Solomon DH, Kim SC. Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta-analysis. J Bone Miner Res 2013; 28: 1729-37
    • (2013) J Bone Miner Res , vol.28 , pp. 1729-1737
    • Gedmintas, L.1    Solomon, D.H.2    Kim, S.C.3
  • 21
    • 84930810331 scopus 로고    scopus 로고
    • Increased risk for atypical fractures associated with bisphosphonate use
    • Lee S, Yin RV, Hirpara H., et al. Increased risk for atypical fractures associated with bisphosphonate use. Fam Pract 2015; 32: 276-81
    • (2015) Fam Pract , vol.32 , pp. 276-281
    • Lee, S.1    Yin, R.V.2    Hirpara, H.3
  • 22
    • 84862988633 scopus 로고    scopus 로고
    • Increasing occurrence of atypical femoral fractures associated with bisphosphonate use
    • Meier RPH, Perneger TV, Stern R, Rizzoli R, Peter RE. Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med 2012; 172: 930-6
    • (2012) Arch Intern Med , vol.172 , pp. 930-936
    • Meier, R.P.H.1    Perneger, T.V.2    Stern, R.3    Rizzoli, R.4    Peter, R.E.5
  • 23
    • 47549117752 scopus 로고    scopus 로고
    • More on atypical fractures of the femoral diaphysis
    • Kwek EB, Koh JS, Howe TS. More on atypical fractures of the femoral diaphysis. N Engl J Med 2008; 359: 316-17
    • (2008) N Engl J Med , vol.359 , pp. 316-317
    • Kwek, E.B.1    Koh, J.S.2    Howe, T.S.3
  • 24
    • 34147179587 scopus 로고    scopus 로고
    • Subtrochanteric insufficiency fractures in patients on alendronate therapy: A caution
    • Goh SK, Yang KY, Koh JS., et al. Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution. J Bone Joint Surg Br 2007; 89: 349-53
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 349-353
    • Goh, S.K.1    Yang, K.Y.2    Koh, J.S.3
  • 25
    • 78751576040 scopus 로고    scopus 로고
    • Subtrochanteric fractures after long-term treatment with bisphosphonates: A European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report
    • Rizzoli R, Akesson K, Bouxsein M., et al. Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporos Int 2011; 22: 373-90
    • (2011) Osteoporos Int , vol.22 , pp. 373-390
    • Rizzoli, R.1    Akesson, K.2    Bouxsein, M.3
  • 26
    • 33845890326 scopus 로고    scopus 로고
    • Effects of continuing or stopping alendronate after 5 years of treatment: The Fracture Intervention Trial Long-term Extension (FLEX): A randomized trial
    • FLEX Research Group.
    • Black DM, Schwartz AV, Ensrud KE, et al. FLEX Research Group. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 2006; 296: 2927-38
    • (2006) JAMA , vol.296 , pp. 2927-2938
    • Black, D.M.1    Schwartz, A.V.2    Ensrud, K.E.3
  • 27
    • 84878217063 scopus 로고    scopus 로고
    • BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate
    • McNabb BL, Vittinghoff E, Schwartz AV., et al. BMD changes and predictors of increased bone loss in postmenopausal women after a 5-year course of alendronate. J Bone Miner Res 2013; 28: 1319-27
    • (2013) J Bone Miner Res , vol.28 , pp. 1319-1327
    • McNabb, B.L.1    Vittinghoff, E.2    Schwartz, A.V.3
  • 28
    • 77952331323 scopus 로고    scopus 로고
    • Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: The FLEX trial
    • FLEX Research Group
    • Schwartz AV, Bauer DC, Cummings SR, et al.; FLEX Research Group. Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial. J Bone Miner Res 2010; 25: 976-82
    • (2010) J Bone Miner Res , vol.25 , pp. 976-982
    • Schwartz, A.V.1    Bauer, D.C.2    Cummings, S.R.3
  • 29
    • 77952314262 scopus 로고    scopus 로고
    • Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur; Fracture Intervention Trial Steering Committee; HORIZON Pivotal Fracture Trial Steering Committee
    • Black DM, Kelly MP, Genant HK., et al. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur; Fracture Intervention Trial Steering Committee; HORIZON Pivotal Fracture Trial Steering Committee. N Engl J Med 2010; 362: 1761-71
    • (2010) N Engl J Med , vol.362 , pp. 1761-1771
    • Black, D.M.1    Kelly, M.P.2    Genant, H.K.3
  • 30
    • 84861668653 scopus 로고    scopus 로고
    • Continuing bisphosphonate treatment for osteoporosis-for whom and for how long
    • Black DM, Bauer DC, Schwartz AV, Cummings SR, Rosen CJ. Continuing bisphosphonate treatment for osteoporosis-for whom and for how long N Engl J Med 2012; 366: 2051-3
    • (2012) N Engl J Med , vol.366 , pp. 2051-2053
    • Black, D.M.1    Bauer, D.C.2    Schwartz, A.V.3    Cummings, S.R.4    Rosen, C.J.5
  • 31
    • 84856184102 scopus 로고    scopus 로고
    • The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
    • Black DM, Reid IR, Boonen S., et al. The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res 2012; 27: 243-54
    • (2012) J Bone Miner Res , vol.27 , pp. 243-254
    • Black, D.M.1    Reid, I.R.2    Boonen, S.3
  • 32
    • 84927732165 scopus 로고    scopus 로고
    • The effect of 6 versus 9 years of zoledronic acid treatment in osteoporosis: A randomized second extension to the HORIZON-Pivotal Fracture Trial (PFT)
    • Black DM, Reid IR, Cauley JA., et al. The effect of 6 versus 9 years of zoledronic acid treatment in osteoporosis: a randomized second extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res 2015; 30: 934-44
    • (2015) J Bone Miner Res , vol.30 , pp. 934-944
    • Black, D.M.1    Reid, I.R.2    Cauley, J.A.3
  • 33
    • 38849130073 scopus 로고    scopus 로고
    • Fracture risk remains reduced one year after discontinuation of risedronate
    • Watts NB, Chines A, Olszynski WP., et al. Fracture risk remains reduced one year after discontinuation of risedronate. Osteoporos Int 2008; 19: 365-72
    • (2008) Osteoporos Int , vol.19 , pp. 365-372
    • Watts, N.B.1    Chines, A.2    Olszynski, W.P.3
  • 35
    • 84864885619 scopus 로고    scopus 로고
    • Regional bone metabolism at the lumbar spine and hip following discontinuation of alendronate and risedronate treatment in postmenopausal women
    • Frost ML, Siddique M, Blake GM., et al. Regional bone metabolism at the lumbar spine and hip following discontinuation of alendronate and risedronate treatment in postmenopausal women. Osteoporos Int 2012; 23: 2107-16
    • (2012) Osteoporos Int , vol.23 , pp. 2107-2116
    • Frost, M.L.1    Siddique, M.2    Blake, G.M.3
  • 36
    • 84904116848 scopus 로고    scopus 로고
    • Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: The FLEX study
    • Bauer DC, Schwartz A, Palermo L., et al. Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: the FLEX study. JAMA Intern Med 2014; 174: 1126-34
    • (2014) JAMA Intern Med , vol.174 , pp. 1126-1134
    • Bauer, D.C.1    Schwartz, A.2    Palermo, L.3
  • 37
    • 84916608247 scopus 로고    scopus 로고
    • Reassessment of fracture risk in women after 3 years of treatment with zoledronic acid: When is it reasonable to discontinue treatment
    • Cosman F, Cauley JA, Eastell R., et al. Reassessment of fracture risk in women after 3 years of treatment with zoledronic acid: when is it reasonable to discontinue treatment J Clin Endocrinol Metab 2014; 99: 4546-54
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 4546-4554
    • Cosman, F.1    Cauley, J.A.2    Eastell, R.3
  • 38
    • 84910019974 scopus 로고    scopus 로고
    • A model of BMD changes after alendronate discontinuation to guide post alendronate BMD monitoring
    • McNabb B, Vittinghoff E, Eastell R., et al. A model of BMD changes after alendronate discontinuation to guide post alendronate BMD monitoring. J Clin Endocrinol Metab 2014; 99: 4094-100
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 4094-4100
    • McNabb, B.1    Vittinghoff, E.2    Eastell, R.3
  • 39
    • 40449104676 scopus 로고    scopus 로고
    • Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin
    • Heiss G, Wallace R, Anderson GL., et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA 2008; 299: 1036-45
    • (2008) JAMA , vol.299 , pp. 1036-1045
    • Heiss, G.1    Wallace, R.2    Anderson, G.L.3
  • 40
    • 79953897155 scopus 로고    scopus 로고
    • Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass
    • Bone HG, Bolognese MA, Yuen CK., et al. Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab 2011; 96: 972-80
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 972-980
    • Bone, H.G.1    Bolognese, M.A.2    Yuen, C.K.3
  • 41
    • 80052746289 scopus 로고    scopus 로고
    • Fracture risk associated with continuation versus discontinuation of bisphosphonates after 5 years of therapy in patients with primary osteoporosis: A systematic review and meta-analysis
    • Fraser LA, Vogt KN, Adachi JD, Thabane L. Fracture risk associated with continuation versus discontinuation of bisphosphonates after 5 years of therapy in patients with primary osteoporosis: a systematic review and meta-analysis. Ther Clin Risk Manag 2011; 7: 157-66
    • (2011) Ther Clin Risk Manag , vol.7 , pp. 157-166
    • Fraser, L.A.1    Vogt, K.N.2    Adachi, J.D.3    Thabane, L.4
  • 42
    • 84856147111 scopus 로고    scopus 로고
    • Bisphosphonate therapy for osteoporosis: The long and short of it
    • Compston JE, Bilezikian JP. Bisphosphonate therapy for osteoporosis: the long and short of it. J Bone Miner Res 2012; 27: 240-2
    • (2012) J Bone Miner Res , vol.27 , pp. 240-242
    • Compston, J.E.1    Bilezikian, J.P.2
  • 44
    • 84880265582 scopus 로고    scopus 로고
    • Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013
    • National Osteoporosis Guideline Group
    • Compston J, Bowring C, Cooper A., et al.; National Osteoporosis Guideline Group. Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas 2013; 75: 392-6
    • (2013) Maturitas , vol.75 , pp. 392-396
    • Compston, J.1    Bowring, C.2    Cooper, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.