Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Cancer Biology and Therapy

Volumn 16, Issue 11, 2015, Pages 1682-1688

  Mayzlish Gati, Einav ^a   Laufer, Dana ^a,b   Grivas, Christopher F ^c   Shaknof, Julia ^a   Sananes, Amiram ^a,b   Bier, Ariel ^a   Ben Harosh, Shani ^b   Belausov, Eduard ^a   Johnson, Michael D ^d,e   Artuso, Emma ^f   Levi, Oshrat ^a   Genin, Ola ^a   Prandi, Cristina ^f   Khalaila, Isam ^b   Pines, Mark ^a   Yarden, Ronit I ^c,e   Kapulnik, Yoram ^a   Koltai, Hinanit ^a  

^a VOLCANI CENTER   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c GEORGETOWN UNIVERSITY   (United States)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e GEORGETOWN UNIVERSITY   (United States)

^f UNIVERSITY OF TURIN   (Italy)

Author keywords

breast cancer; cell motility, microtubule; plant hormone; strigolactone; xenograft

Indexed keywords

ANTINEOPLASTIC AGENT; MEB 55; PACLITAXEL; ST 362; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; LACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER MODEL; CELL PROLIFERATION ASSAY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; IC50; IN VIVO STUDY; LOW DRUG DOSE; MICROTUBULE; MONOTHERAPY; MOUSE; NONHUMAN; PHENOTYPE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL MOTION; DRUG EFFECTS; DRUG POTENTIATION; DRUG SCREENING; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DRUG SYNERGISM; FEMALE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LACTONES; MICE, INBRED BALB C; MICE, INBRED ICR; MICE, NUDE; PACLITAXEL; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84948578744     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2015.1070982     Document Type: Article

References (19)

1. L.Lin, R.X.Tan. Cross-kingdom actions of phytohormones: a functional scaffold exploration. Chem Rev 2011; 111:2734-60; PMID:21250668; http://dx.doi.org/10.1021/cr100061j
2. M.Umehara, A.Hanada, S.Yoshida, K.Akiyama, T.Arite, N.Takeda-Kamiya, H.Magome, Y.Kamiya, K.Shirasu, K.Yoneyama, et al. Inhibition of shoot branching by new terpenoid plant hormones. Nature 2008; 455:195-200; PMID:18690207; http://dx.doi.org/10.1038/nature07272
3. V.Gomez-Roldan, S.Fermas, P.B.Brewer, V.Puech-Pages, E.A.Dun, J.-P.Pillot, F.Letisse, R.Matusova, S.Danoun, J.-C.Portais, et al. Strigolactone inhibition of shoot branching. Nature 2008; 455:189-94; PMID:18690209; http://dx.doi.org/10.1038/nature07271
4. X.Xie, K.Yoneyama, K.Yoneyama. The Strigolactone Story. Ann Rev Phytopathol 2010; 48:93-117; PMID:20687831; http://dx.doi.org/10.1146/annurev-phyto-073009-114453
5. B.Zwanenburg, S.K.Nayak, T.V.Charnikhova, H.J.Bouwmeester. New strigolactone mimics: Structure–activity relationship and mode of action as germinating stimulants for parasitic weeds. Bioorg Med Chem Lett 2013; 23:5182-6; PMID:23920440; http://dx.doi.org/10.1016/j.bmcl.2013.07.004
6. C.Prandi, E.G.Occhiato, S.Tabasso, P.Bonfante, M.Novero, D.Scarpi, M.E.Bova, I.Miletto. New potent fluorescent analogues of strigolactones: synthesis and biological activity in parasitic weed germination and fungal branching. Eur J Organ Chem 2011; 2011:3781-93; http://dx.doi.org/10.1002/ejoc.201100616
7. C.Pollock, H.Koltai, Y.Kapulnik, C.Prandi, R.Yarden. Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells. Breast Cancer Res Treat 2012; 134:1041-55; PMID:22476848; http://dx.doi.org/10.1007/s10549-012-1992-x
8. C.B.Pollock, S.McDonough, V.S.Wang, H.Lee, L.Ringer, X.Li, C.Prandi, R.J.Lee, A.S.Feldman, H.Koltai. Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogramed primary prostate cancer cells. Oncotarget 2014; 5:1683-98; PMID:24742967
9. D.Sliva, M.T.Rizzo, D.English. Phosphatidylinositol 3-kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator. J Biol Chem 2002; 277:3150-7; PMID:11689575; http://dx.doi.org/10.1074/jbc.M109579200
10. C.-C.Liang, A.Y.Park, J.-L.Guan. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007; 2:329-33; PMID:17406593; http://dx.doi.org/10.1038/nprot.2007.30
11. S.B.Horwitz, D.Cohen, S.Rao, I.Ringel, H.J.Shen, C.P.Yang. Taxol: mechanisms of action and resistance. J Natl Cancer Inst Monogr 1993:55-61; PMID:7912530
12. M.Carré, G.Carles, N.André, S.Douillard, J.Ciccolini, C.Briand, D.Braguer. Involvement of microtubules and mitochondria in the antagonism of arsenic trioxide on paclitaxel-induced apoptosis. Biochem Pharmacol 2002; 63:1831-42; PMID:12034367; http://dx.doi.org/10.1016/S0006-2952(02)00922-X
13. C.Ferlini, G.Raspaglio, S.Mozzetti, L.Cicchillitti, F.Filippetti, D.Gallo, C.Fattorusso, G.Campiani, G.Scambia. The seco-taxane IDN5390 is able to target class III β-tubulin and to overcome paclitaxel resistance. Cancer Res 2005; 65:2397-405; PMID:15781655; http://dx.doi.org/10.1158/0008-5472.CAN-04-3065
14. C.Elie-Caille, F.Severin, J.Helenius, J.Howard, D.J.Muller, A.A.Hyman. Straight GDP-tubulin protofilaments form in the presence of taxol. Curr Biol 2007; 17:1765-70; PMID:17919908; http://dx.doi.org/10.1016/j.cub.2007.08.063
15. M.A.Ojeda-Lopez, D.J.Needleman, C.Song, A.Ginsburg, P.A.Kohl, Y.Li, H.P.Miller, L.Wilson, U.Raviv, M.C.Choi. Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch. Nat Mater 2014; 13:195-203; PMID:24441880; http://dx.doi.org/10.1038/nmat3858
16. I.Kaverina, A.Straube. Regulation of cell migration by dynamic microtubules. Semin Cell Dev Biol 2011; 22:968-74; PMID:22001384; http://dx.doi.org/10.1016/j.semcdb.2011.09.017
17. P.B.Schiff, S.B.Horwitz. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci 1980; 77:1561-5; PMID:6103535; http://dx.doi.org/10.1073/pnas.77.3.1561
18. D.H.Jones, T.Nakashima, O.H.Sanchez, I.Kozieradzki, S.V.Komarova, I.Sarosi, S.Morony, E.Rubin, R.Sarao, C.V.Hojilla. Regulation of cancer cell migration and bone metastasis by RANKL. Nature 2006; 440:692-6; PMID:16572175; http://dx.doi.org/10.1038/nature04524
19. O.Halevy, O.Genin, H.Barzilai-Tutsch, Y.Pima, O.Levi, I.Moshe, M.Pines. Inhibition of muscle fibrosis and improvement of muscle histopathology in dysferlin knock-out mice treated with halofuginone. Histol Histopathol 2013; 28:211-26; PMID:23275304