IL-25 promotes the function of CD4+CD25 + T regulatory cells and prolongs skin-graft survival in murine models

International Immunopharmacology

Volumn 28, Issue 2, 2015, Pages 931-937

  Tang, Jiayou ^a   Zhou, Xiaohui ^a   Liu, Jie ^a   Meng, Qingshu ^a   Han, Yang ^a   Wang, Zhulin ^a   Fan, Huimin ^a   Liu, Zhongmin ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Interleukin 25; NFAT2; Regulatory T cells; Skin transplantation

Indexed keywords

INTERLEUKIN 25; TRANSCRIPTION FACTOR FOXP3; D17WSU104E PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; NFATC1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR NFAT;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SKIN GRAFT; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; GENETICS; IMMUNOLOGY; SKIN TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

ADOPTIVE TRANSFER; ANIMALS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKINS; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; SKIN TRANSPLANTATION; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE;

EID: 84948572141     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.03.036     Document Type: Article

References (38)

1. C. Dong, and R.A. Flavell Cell fate decision: T-helper 1 and 2 subsets in immune responses Arthritis Res. 2 2000 179 188
2. L.H. Glimcher, and K.M. Murphy Lineage commitment in the immune system: the T helper lymphocyte grows up Genes Dev. 14 2000 1693 1711
3. S.Z. Josefowicz, L.F. Lu, and A.Y. Rudensky Regulatory T cells: mechanisms of differentiation and function Annu. Rev. Immunol. 30 2012 531 564
4. D.R. Littman, and A.Y. Rudensky Th17 and regulatory T cells in mediating and restraining inflammation Cell 140 2010 845 858
5. S. Hori The Foxp3 interactome: a network perspective of T(reg) cells Nat. Immunol. 13 2012 943 945
6. X. Zhou, N. Kong, H. Zou, and et al. Therapeutic potential of TGF-beta-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases Autoimmunity 44 2011 43 50
7. E. Andreakos, and N.G. Papadopoulos IL-25: the missing link between allergy, viral infection, and asthma? Sci. Transl. Med. 6 2014 (256 fs38)
8. M.A. Kleinschek, A.M. Owyang, B. Joyce-Shaikh, and et al. IL-25 regulates Th17 function in autoimmune inflammation J. Exp. Med. 204 2007 161 170
9. K.S. Liu, X.Q. Fan, L. Zhang, and et al. Effects of recombinant human interleukin-10 on Treg cells, IL-10 and TGF-beta in transplantation of rabbit skin Mol. Med. Rep. 9 2014 639 644
10. D.A. Horwitz, S.G. Zheng, J. Wang, and J.D. Gray Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4 + Treg Eur. J. Immunol. 38 2008 912 915
11. Y.P. Rubtsov, R.E. Niec, S. Josefowicz, and et al. Stability of the regulatory T cell lineage in vivo Science 329 2010 1667 1671
12. A. Kimura, and T. Kishimoto IL-6: regulator of Treg/Th17 balance Eur. J. Immunol. 40 2013 1830 1835
13. W. Gao, L. Thompson, Q. Zhou, and et al. Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6 Cell Cycle 8 2009 1444 1450
14. J. Verhagen, L. Gabrysova, E.R. Shepard, and D.C. Wraith Ctla-4 modulates the differentiation of inducible Foxp3 + Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis PLoS One 9 2013 e108023
15. S. Liu, J. Ren, and J. Li IL-17RA in intestinal inflammation: structure, signaling, function, and clinical application Inflamm. Bowel Dis. 21 2015 154 166
16. P. Angkasekwinai, H. Park, Y.H. Wang, and et al. Interleukin 25 promotes the initiation of proallergic type 2 responses J. Exp. Med. 204 2007 1509 1517
17. Y.Y. Setiady, J.A. Coccia, and P.U. Park In vivo depletion of CD4+FOXP3 + Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII + phagocytes Eur. J. Immunol. 40 2010 780 786
18. Y. Wu, M. Borde, V. Heissmeyer, and et al. FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 126 2006 375 387
19. T.R. Torgerson, A. Genin, C. Chen, and et al. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression J. Immunol. 183 2009 907 915
20. H. Spits, D. Artis, M. Colonna, and et al. Innate lymphoid cells - a proposal for uniform nomenclature Nat. Rev. Immunol. 13 2013 145 149
21. C. Zaph, Y. Du, S.A. Saenz, and et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine J. Exp. Med. 205 2008 2191 2198
22. C.L. Maynard, and C.T. Weaver Intestinal effector T cells in health and disease Immunity 31 2009 389 400
23. E.A. Rickel, L.A. Siegel, B.R. Yoon, and et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities J. Immunol. 181 2008 4299 4310
24. E.I. Agorogiannis, F.S. Regateiro, D. Howie, H. Waldmann, and S.P. Cobbold Th17 cells induce a distinct graft rejection response that does not require IL-17A Am. J. Transplant. 12 2012 835 845
25. H. Zhu, J. Li, S. Wang, K. Liu, L. Wang, and L. Huang Hmgb1-TLR4-IL-23-IL-17A axis promote ischemia-reperfusion injury in a cardiac transplantation model Transplantation 95 2013 1448 1454
26. R. Chadha, S. Heidt, N.D. Jones, and K.J. Wood Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance? Transplantation 91 1995 939 945
27. J. Su, T. Chen, X.Y. Ji, and et al. IL-25 downregulates Th1/Th17 immune response in an IL-10-dependent manner in inflammatory bowel disease Inflamm. Bowel Dis. 19 2013 720 728
28. B.M. Hall, M.E. Jelbart, and S.E. Dorsch Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporine Transplantation 37 1984 595 600
29. X. Zhou, B. Li, H. Fan, and Z. Liu Control of regulatory T cells and T helper cells in human diseases: from bench to bedside J. Mol. Cell Biol. 5 2013 210 211
30. K. Lee, V. Nguyen, K.M. Lee, S.M. Kang, and Q. Tang Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy Am. J. Transplant. 14 2014 27 38
31. C. Moore, G. Tejon, C. Fuentes, and et al. Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection Eur. J. Immunol. 00 2014 1 12
32. B. Liu, H. Zhang, J. Li, and et al. Triptolide downregulates Treg cells and the level of IL-10, TGF-beta, and VEGF in melanoma-bearing mice Planta Med. 79 2013 1401 1407
33. H. Mearns, E.E. Forbes-Blom, M. Camberis, and et al. IL-25 exhibits disparate roles during Th2-cell differentiation versus effector function Eur. J. Immunol. 44 2014 1976 1980
34. Y. Maezawa, H. Nakajima, K. Suzuki, and et al. Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling J. Immunol. 176 2006 1013 1018
35. E. Serfling, S. Chuvpilo, J. Liu, T. Hofer, and A. Palmetshofer NFATc1 autoregulation: a crucial step for cell-fate determination Trends Immunol. 27 2006 461 469
36. M. Asagiri, K. Sato, T. Usami, and et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis J. Exp. Med. 202 2005 1261 1269
37. A. Rao, C. Luo, and P.G. Hogan Transcription factors of the NFAT family: regulation and function Annu. Rev. Immunol. 15 1997 707 747
38. Y. Tone, K. Furuuchi, Y. Kojima, and et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer Nat. Immunol. 9 2 2007 194 202