Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis?

Climacteric

Volumn 18, Issue , 2015, Pages 22-31

  Bolland, M J ^a   Grey, A ^a   Reid, I R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Calcium; Osteoporosis; Prevention; Supplements; Treatment; Vitamin D

Indexed keywords

CALCIUM; VITAMIN D; CALCIUM INTAKE;

ARTICLE; BONE DENSITY; CALCIUM INTAKE; CONSTIPATION; DRUG MEGADOSE; FOREARM FRACTURE; HEART INFARCTION; HIP FRACTURE; HORMONE SUBSTITUTION; HOSPITALIZATION; HUMAN; HYPERCALCEMIA; LOW DRUG DOSE; META ANALYSIS; MONOTHERAPY; NEPHROLITHIASIS; OSTEOMALACIA; OSTEOPOROSIS; PRIORITY JOURNAL; RISK FACTOR; RISK REDUCTION; SPINE FRACTURE; SUN EXPOSURE; VITAMIN D DEFICIENCY; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENT; DRUG EFFECTS; FEMALE; FRACTURES, BONE; MYOCARDIAL INFARCTION; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOPOROTIC FRACTURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); STROKE;

BONE DENSITY; CALCIUM, DIETARY; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; FEMALE; FRACTURES, BONE; HUMANS; MYOCARDIAL INFARCTION; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOPOROTIC FRACTURES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STROKE; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84948569261     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.3109/13697137.2015.1098266     Document Type: Article

References (68)

1. World Health Organization., Food and Agriculture Organization of the United Nations. Calcium requirements: report of an FAO/WHO Expert Group, Rome, Italy, 23-30 May 1961. Geneva: World Health Organization 1962
2. Heaney RP, Recker RR, Saville PD. Calcium balance and calcium requirements in middle-aged women. Am J Clin Nutr 1977; 30: 1603-11
3. Heaney RP, Recker RR, Saville PD. Menopausal changes in calcium balance performance. J Lab Clin Med 1978; 92: 953-63
4. Consensus conference: Osteoporosis. JAMA 1984; 252: 799-802
5. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993; 94: 646-50
6. Chapuy MC, Arlot ME, Duboeuf F., et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992; 327: 1637-42
7. Grey A, Bolland M. Web of industry, advocacy, and academia in the management of osteoporosis. BMJ 2015; 351: h3170
8. Bailey RL, Dodd KW, Goldman JA., et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr 2010; 140: 817-22
9. Anderson JJ, Roggenkamp KJ, Suchindran CM. Calcium intakes and femoral and lumbar bone density of elderly U.S. men and women: National Health and Nutrition Examination Survey 2005-2006 analysis. J Clin Endocrinol Metab 2012; 97: 4531-9
10. Castro-Lionard K, Dargent-Molina P, Fermanian C, Gonthier R, Cassou B. Use of calcium supplements, vitamin D supplements and specific osteoporosis drugs among French women aged 75-85 years: patterns of use and associated factors. Drugs Aging 2013; 30: 1029-38
11. Xiao Q, Murphy RA, Houston DK., et al. Dietary and supplemental calcium intake and cardiovascular disease mortality: The National Institutes of Health-AARP Diet and Health Study. JAMA Intern Med 2013; 173: 639-46
12. Bolland MJ, Leung W, Tai V., et al. Calcium intake and risk of fracture: systematic review. BMJ 2015; 351: h4580
13. Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014; 2: 307-20
14. Avenell A, Mak JC, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; 4: CD000227
15. Reid IR, Bolland MJ. Calcium risk-benefit updated-new WHI analyses. Maturitas 2014; 77: 1-3
16. Chapuy MC, Pamphile R, Paris E., et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002; 13: 257-64
17. Chapuy MC, Arlot ME, Delmas PD, Meunier PJ. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994; 308: 1081-2
18. Bischoff-Ferrari HA, Willett WC, Wong JB., et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005; 293: 2257-64
19. Boonen S, Lips P, Bouillon R., et al. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007; 92: 1415-23
20. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009: CD000227
21. Reid IR, Bolland MJ, Sambrook PN, Grey A. Calcium supplementation: balancing the cardiovascular risks. Maturitas 2011; 69: 289-95
22. Sambrook PN, Cameron ID, Chen JS., et al. Does increased sunlight exposure work as a strategy to improve vitamin D status in the elderly: a cluster randomised controlled trial. Osteoporos Int 2012; 23: 615-24
23. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA., et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 2007; 86: 1780-90
24. Reid IR, Bolland MJ, Grey A. Effect of calcium supplementation on hip fractures. Osteoporos Int 2008; 19: 1119-23
25. Tang BMP, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007; 370: 657-66
26. Bolland MJ, Grey A. A case study of discordant overlapping meta-analyses: vitamin D supplements and fracture. PLoS One 2014; 9: e115934
27. Tai V, Leung W, Grey A, Reid IR, Bolland MJ. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ 2015;351:h4183
28. Kanis JA, Borgstrom F, De Laet C., et al. Assessment of fracture risk. Osteoporos Int 2005; 16: 581-9
29. Cranney A, Guyatt G, Krolicki N., et al. A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis. Osteoporos Int 2001; 12: 140-51
30. Liberman UA, Weiss SR, Broll J., et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med 1995; 333: 1437-43
31. Cummings SR, Black DM, Thompson DE., et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA 1998; 280: 2077-82
32. Black DM, Delmas PD, Eastell R., et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007; 356: 1809-22
33. Cummings SR, San Martin J, McClung MR., et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361: 756-65
34. Freemantle N, Cooper C, Diez-Perez A., et al. Results of indirect and mixed treatment comparison of fracture efficacy for osteoporosis treatments: a meta-analysis. Osteoporos Int 2013; 24: 209-17
35. Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014; 383: 146-55
36. Bolland MJ, Grey A, Gamble GD, Reid IR. Vitamin D supplementation and falls: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014; 2: 573-80
37. Witham MD, Price RJ, Struthers AD., et al. Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension: the VitDISH randomized controlled trial. JAMA Intern Med 2013; 173: 1672-9
38. Lopez-Torres Hidalgo J, Grupo A. [Effect of calcium and vitamin D in the reduction of falls in the elderly: a randomized trial versus placebo]. Med Clin (Barc) 2014; 142: 95-102
39. Wood AD, Secombes KR, Thies F., et al. A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity Osteoporos Int 2014; 25: 305-15
40. Uusi-Rasi K, Patil R, Karinkanta S., et al. Exercise and vitamin D in fall prevention among older women: a randomized clinical trial. JAMA Intern Med 2015; 175: 703-11
41. Pfeifer M, Begerow B, Minne HW., et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 2009; 20: 315-22
42. Bolland MJ, Grey A. Inconsistent data in text and tables. Osteoporos Int 2015 May 28. Epub ahead of print
43. Pfeifer M. Different outcomes of meta-analyses and data inconsistency. Osteoporos Int 2015 Jun 18. Epub ahead of print
44. Bolland MJ, Grey A, Reid IR. Differences in overlapping meta-analyses of vitamin D supplements and falls. J Clin Endocrinol Metab 2014; 99: 4265-72
45. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 2014; 348: g2035
46. Bonnick S, Broy S, Kaiser F., et al. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density. Curr Med Res Opin 2007; 23: 1341-9
47. McClung M, Miller P, Recknor C., et al. Zoledronic acid for the prevention of bone loss in postmenopausal women with low bone mass: a randomized controlled trial. Obstet Gynecol 2009; 114: 999-1007
48. Grey A, Bolland M, Wattie D., et al. Prolonged antiresorptive activity of zoledronate: a randomized, controlled trial. J Bone Miner Res 2010; 25: 2251-5
49. McCloskey EV, Beneton M, Charlesworth D., et al. Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study. J Bone Miner Res 2007; 22: 135-41
50. Anderson GL, Limacher M, Assaf AR., et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004; 291: 1701-12
51. Rossouw JE, Anderson GL, Prentice RL., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33
52. Grant AM, Avenell A, Campbell MK., et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005; 365: 1621-8
53. Jackson RD, LaCroix AZ, Gass M., et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006; 354: 669-83
54. Prince RL, Devine A, Dhaliwal SS, Dick IM. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006; 166: 869-75
55. Reid IR, Mason B, Horne A., et al. Randomized controlled trial of calcium in healthy older women. Am J Med 2006; 119: 777-85
56. Prentice RL, Jackson RD, Pettinger M, Rossouw JE. Incidence of milk alkali syndrome in the Women's Health Initiative clinical trial and cohort study: response to Neupane. Osteoporos Int 2014; 25: 1195
57. Bolland MJ, Avenell A, Baron JA., et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010; 341: c3691
58. Lewis JR, Zhu K, Prince RL. Adverse events from calcium supplementation: relationship to errors in myocardial infarction self-reporting in randomized controlled trials of calcium supplementation. J Bone Miner Res 2012; 27: 719-22
59. Sanders KM, Stuart AL, Williamson EJ., et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303: 1815-22
60. Bischoff-Ferrari H, Dawson-Hughes B, Orav J., et al. Effects of 3 monthly vitamin D supplementation strategies among fallers age 70 years and older: A double-blind randomized controlled trial. J Bone Miner Res 2012; 27 (Suppl 1): S132
61. Smith H, Anderson F, Raphael H., et al. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women-a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford) 2007; 46: 1852-7
62. Lips P, Graafmans WC, Ooms ME, Bezemer PD, Bouter LM. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med 1996; 124: 400-6
63. Meyer HE, Smedshaug GB, Kvaavik E., et al. Can vitamin D supplementation reduce the risk of fracture in the elderly A randomized controlled trial. J Bone Miner Res 2002; 17: 709-15
64. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326: 469
65. Lyons RA, Johansen A, Brophy S., et al. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos Int 2007; 18: 811-18
66. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2014; 2: 76-89
67. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011; 342: d2040
68. Hsia J, Heiss G, Ren H., et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation 2007; 115: 846-54