Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

Critical Care Medicine

Volumn 40, Issue 5, 2012, Pages 1523-1528

  Roberts, Darren M ^a   Roberts, Jason A ^a,b   Roberts, Michael S ^a,b   Liu, Xin ^a,b   Nair, Priya ^c   Cole, Louise ^d   Lipman, Jeffrey ^a   Bellomo, Rinaldo ^e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d NEPEAN HOSPITAL   (Australia)

^e AUSTIN HEALTH   (Australia)

Author keywords

Antibiotic; critically ill patient; dialysis; pharmacodynamics; pharmacokinetics; therapeutic drug monitoring

Indexed keywords

CIPROFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN;

ACUTE KIDNEY FAILURE; ADULT; AGED; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTINUOUS RENAL REPLACEMENT THERAPY; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; FEMALE; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; OBSERVATIONAL STUDY; PHARMACOKINETICS; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ACUTE KIDNEY INJURY; AGED; ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; CRITICAL ILLNESS; FEMALE; HEMOFILTRATION; HUMANS; MALE; MIDDLE AGED; PENICILLANIC ACID; PIPERACILLIN; THIENAMYCINS; VANCOMYCIN;

EID: 84860229974     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318241e553     Document Type: Article

References (29)

1. RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, et al: Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 2009; 361:1627-1638
2. Roberts JA, Lipman J: Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med 2009; 37:840-851; quiz 859
3. Bugge JF: Pharmacokinetics and drug dosing adjustments during continuous venovenous hemofiltration or hemodiafiltration in critically ill patients. Acta Anaesthesiol Scand 2001; 45:929-934
4. Choi G, Gomersall CD, Tian Q, et al: Principles of antibacterial dosing in continuous renal replacement therapy. Crit Care Med 2009; 37:2268-2282
5. Uchino S, Kellum JA, Bellomo R, et al: Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 2005; 294:813-818
6. Joy MS, Matzke GR, Armstrong DK, et al: A primer on continuous renal replacement therapy for critically ill patients. Ann Pharmacother 1998; 32:362-375
7. Joy MS, Matzke GR, Frye RF, et al: Determinants of vancomycin clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis. Am J Kidney Dis 1998; 31:1019-1027
8. Vincent JL, Rello J, Marshall J, et al: International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009; 302:2323-2329
9. European Committee on Antimicrobial Susceptibility Testing (EUCAST): Breakpoint tables for interpretation of MICs and zone diameters. Version 1.0 December 2009. Available at: http://www.eucast.org/fileadmin/src/media/PDFs/ EUCAST-files/Disk-test-documents/EUCAST-breakpoints-v1.0-20091221.pdf. Accessed April 2, 2010
10. Craig WA: Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998; 26:1-10; quiz 11-12
11. Mouton JW, den Hollander JG: Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model. Antimicrob Agents Chemother 1994; 38:931-936
12. Roberts JA, Ulldemolins M, Roberts MS, et al: Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept. Int J Antimicrob Agents 2010; 36:332-339
13. Moise-Broder PA, Forrest A, Birmingham MC, et al: Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections. Clin Pharmacokinet 2004; 43:925-942
14. Jeffres MN, Isakow W, Doherty JA, et al: A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia. Clin Ther 2007; 29:1107-1115
15. Rybak MJ, Lomaestro BM, Rotschafer JC, et al: Vancomycin therapeutic guidelines: A summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis 2009; 49:325-327
16. Forrest A, Nix DE, Ballow CH, et al: Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 1993; 37:1073-1081
17. Baptista JP, Udy AA, Sousa E, et al: A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance. Crit Care 2011; 15:R139
18. Roberts JA, Mehta RL, Lipman J: Sustained low efficiency dialysis allows rational renal replacement therapy, but does it allow rational drug dosing? Crit Care Med 2011; 39:602-603
19. Fuster-Lluch O, Geronimo-Pardo M, Peyro-Garcia R, et al: Glomerular hyperfiltration and albuminuria in critically ill patients. Anaesth Intensive Care 2008; 36:674-680
20. Gous AG, Dance MD, Lipman J, et al: Changes in vancomycin pharmacokinetics in critically ill infants. Anaesth Intensive Care 1995; 23:678-682
21. Marik PE: Aminoglycoside volume of distribution and illness severity in critically ill septic patients. Anaesth Intensive Care 1993; 21:172-173
22. Pea F, Viale P: The antimicrobial therapy puzzle: Could pharmacokinetic-pharmacodynamic relationships be helpful in addressing the issue of appropriate pneumonia treatment in critically ill patients? Clin Infect Dis 2006; 42:1764-1771
23. Valtonen M, Tiula E, Backman JT, et al: Elimination of meropenem during continuous veno-venous haemofiltration and haemodiafiltration in patients with acute renal failure. J Antimicrob Chemother 2000; 45:701-704
24. Valtonen M, Tiula E, Takkunen O, et al: Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure. J Antimicrob Chemother 2001; 48:881-885
25. Malone RS, Fish DN, Abraham E, et al: Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother 2001; 45:2949-2954
26. Thalhammer F, Horl WH: Pharmacokinetics of meropenem in patients with renal failure and patients receiving renal replacement therapy. Clin Pharmacokinet 2000; 39:271-279
27. DelDot ME, Lipman J, Tett SE: Vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltration. Br J Clin Pharmacol 2004; 58: 259-268
28. Isla A, Rodriguez-Gascon A, Troconiz IF, et al: Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy. Clin Pharmacokinet 2008; 47:173-180
29. Taccone FS, Laterre PF, Dugernier T, et al: Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care 2010; 14:R126