GREMLIN 2 mutations and dental anomalies

Journal of Dental Research

Volumn 94, Issue 12, 2015, Pages 1646-1652

  Kantaputra, P N ^a,b   Kaewgahya, M ^a   Hatsadaloi, A ^c   Vogel, P ^d   Kawasaki, K ^e   Ohazama, A ^e   Ketudat Cairns, J R ^f,g  

^a CHIANG MAI UNIVERSITY   (Thailand)

^b Dentaland Clinic   (Thailand)

^c Dental Home Clinic   (Thailand)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^f SURANAREE UNIVERSITY OF TECHNOLOGY   (Thailand)

^g Krung Thep Maha Nakhon   (Thailand)

Author keywords

hypodontia; microdontia; missing teeth; short tooth roots; taurodontism; tooth agenesis

Indexed keywords

GREM2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; HYPODONTIA; IN SITU HYBRIDIZATION; MISSENSE MUTATION; MOLECULAR GENETICS; MOUSE; MUTATION; PHYSIOLOGY; TOOTH; TOOTH MALFORMATION;

AMINO ACID SEQUENCE; ANIMALS; ANODONTIA; HUMANS; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; TOOTH; TOOTH ABNORMALITIES;

EID: 84948390495     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034515608168     Document Type: Article

References (27)

1. Arte S, Parmanen S, Pirinen S, Alaluusua S, Nieminen P,. 2013. Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations. PLoS One. 8 (8): e73705.
2. Avsian-Kretchmer O, Hsueh AJ,. 2004. Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol Endocrinol. 18 (1): 1-12.
3. Cheung CL, Lau KS, Sham PC, Tan KC, Kung AW,. 2013. Genetic variants in GREM2 are associated with bone mineral density in a southern Chinese population. J Clin Endocrinol Metab. 98 (9): E1557-E1561.
4. Hinck AP,. 2012. Structural studies of the TGF-βs and their receptors: insights into evolution of the TGF-b superfamily. FEBS Lett. 586 (14): 1860-1870.
5. Im J, Kim H, Kim S, Jho EH,. 2007. Wnt/beta-catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway. Biochem Biophys Res Commun. 354 (1): 296-301.
6. Jezewski PA, Vieira AR, Nishimura C, Ludwig B, Johnson M, O'Brien SE, Daack-Hirsch S, Schultz RE, Weber A, Nepomucena B, et al. 2003. Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. J Med Genet. 40 (6): 399-407.
7. Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R,. 2013. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 140 (2): 423-432.
8. Kantaputra P, Kaewgahya M, Jotikasthira D, Kantaputra W,. 2014. Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations. Am J Med Genet Part A. 164A (4): 1041-1048.
9. Kantaputra P, Kaewgahya M, Kantaputra W,. 2014. WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity. Am J Med Genet Part A. 164A (2): 360-363.
10. Kantaputra P, Sripathomsawat W,. 2011. WNT10A and isolated hypodontia. Am J Med Genet Part A. 155A (5): 1119-1122.
11. Kattamuri C, Luedeke DM, Nolan K, Rankin SA, Greis KD, Zorn AM, Thompson TB,. 2012. Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. J Mol Biol. 424 (5): 313-327.
12. Minabe-Saegusa C, Saegusa H, Tsukahara M, Noguchi S,. 1998. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 40 (3): 343-353.
13. Mueller TD, Nickel J,. 2012. Promiscuity and specificity in BMP receptor activation. FEBS Lett. 586 (14): 1846-1859.
14. Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB,. 2013. Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Structure. 21 (8): 1417-1429.
15. Satokata I, Maas R,. 1994. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet. 6 (4): 348-356.
16. Sudo S, Avsian-Kretchmer O, Wang LS, Hsueh AJ,. 2004. Protein related to DAN and Cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 279 (22): 23134-23141.
17. Sun J, Zhuang FF, Mullersman JE, Chen H, Robertson EJ, Warburton D, Liu YH, Shi W,. 2006. BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. J Biol Chem. 281 (39): 29349-29356.
18. Tucker AS, Matthews KL, Sharpe PT,. 1998. Transformation of tooth type induced by inhibition of BMP signaling. Science. 282 (5391): 1136-1138.
19. Tucker AS, Sharpe PT,. 1999. Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res. 78 (4): 826-834.
20. van den Boogaard MJ, Dorland M, Beemer FA, van Amstel HK,. 2000. MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. Nat Genet. 24 (4): 342-343.
21. Vastardis H,. 2000. The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop. 117 (6): 650-656.
22. -/- mice. Vet Pathol. 52 (1): 224-229.
23. Walsh DW, Godson C, Brazil DP, Martin F,. 2010. Extracellular BMP-antagonist regulation in development and disease: tied up in knots. Trends Cell Biol. 20 (5): 244-256.
24. Yin W, Bian Z,. 2015. The gene network underlying hypodontia. J Dent Res. 94 (7): 878-885.
25. Zhang Y, Zhang Z, Zhao X, Yu X, Hu Y, Geronimo B, Fromm SH, Chen YP,. 2000. A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development. 127 (7): 1431-1443.
26. Zhao X, Zhang Z, Song Y, Zhang X, Zhang Y, Hu Y, Fromm SH, Chen Y,. 2000. Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech Dev. 99 (1-2): 29-38.
27. Zuniga E, Rippen M, Alexander C, Schilling TF, Crump JG,. 2011. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 138 (23): 5147-5156.