Sequence Mutation and Structural Alteration Transform a Noncatalytic DNA Sequence into an Efficient RNA-Cleaving DNAzyme

Journal of Molecular Evolution

Volumn 81, Issue 5-6, 2015, Pages 245-253

  Chan, Laura ^a   Tram, Kha ^a   Gysbers, Rachel ^a,b   Gu, Jimmy ^a   Li, Yingfu ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

8 17; DNAzyme; In vitro selection; Molecular evolution; RNA cleavage

Indexed keywords

DEOXYRIBOZYME; RIBONUCLEASE;

CHEMISTRY; CONFORMATION; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE;

BASE SEQUENCE; DNA, CATALYTIC; KINETICS; NUCLEIC ACID CONFORMATION; RIBONUCLEASES; SELEX APTAMER TECHNIQUE;

EID: 84948387111     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-015-9712-x     Document Type: Article

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