Non-eosinophilic nasal polyps shows increased epithelial proliferation and localized disease pattern in the early stage

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Kim, Dong Kyu ^a   Jin, Hong Ryul ^b   Eun, Kyoung Mi ^b   Mutusamy, Somasundran ^b   Cho, Seong H ^c   Oh, Sohee ^b   Kim, Dae Woo ^b  

^a Hallym University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 22; INTERLEUKIN 23P19; INTERLEUKIN 4; INTERLEUKIN 5; KI 67 ANTIGEN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; CYTOKINE;

ADULT; ALGORITHM; ARTICLE; ASIAN; ATOPY; CELL PROLIFERATION; CHRONIC RHINOSINUSITIS; CLINICAL EVALUATION; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; ENDOSCOPY; EOSINOPHILIA; EPITHELIZATION; ETHMOID SINUS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IFN GAMMA GENE; IL 13 GENE; IL 17A GENE; IL 22 GENE; IL 23P19 GENE; IL 4 GENE; IL 5 GENE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MAJOR CLINICAL STUDY; NON EOSINOPHILIC NASAL POLYP; NOSE POLYP; PERIOSTIN GENE; SCORING SYSTEM; TGF BETA2 GENE; TGF BETA3 GENE; TNF ALPHA GENE; EOSINOPHIL; EPITHELIUM CELL; FEMALE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADULT; CELL PROLIFERATION; CYTOKINES; EOSINOPHILS; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; NASAL POLYPS;

EID: 84947999014     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139945     Document Type: Article

References (38)

1. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004; 114(6 Suppl):155-212. PMID: 15577865
2. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012; 50(1):1-12. PMID: 22469599
3. Polzehl D, Moeller P, Riechelmann H, Perner S. Distinct features of chronic rhinosinusitis with and without nasal polyps. Allergy. 2006; 61(11):1275-9. PMID: 17002702
4. Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy. 2006; 61(11):1280-9. PMID: 17002703
5. Van Bruaene N, Derycke L, Perez-Novo CA, Gevaert P, Holtappels G, De Ruyck N, et al. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol. 2009; 124(2):253-9, 9 e1-2. doi: 10.1016/j.jaci.2009.04.013 PMID: 19500825
6. Zhang N, Holtappels G, Claeys C, Huang G, van Cauwenberge P, Bachert C. Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China. Am J Rhinol. 2006; 20(4):445-50. PMID: 16955777
7. Cao PP, Li HB, Wang BF, Wang SB, You XJ, Cui YH, et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol. 2009; 124(3):478-84, 84 e1-2. doi: 10.1016/j.jaci.2009.05.017 PMID: 19541359
8. Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol. 2008; 122(5):961-8. doi: 10.1016/j.jaci.2008.07.008 PMID: 18804271
9. Ishitoya J, Sakuma Y, Tsukuda M. Eosinophilic chronic rhinosinusitis in Japan. Allergol Int. 2010; 59 (3):239-45. doi: 10.2332/allergolint.10-RAI-0231 PMID: 20657162
10. Akdis CA, Bachert C, Cingi C, Dykewicz MS, Hellings PW, Naclerio RM, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2013; 131(6):1479-90. doi: 10.1016/j.jaci.2013.02.036 PMID: 23587334
11. Kountakis SE, Arango P, Bradley D, Wade ZK, Borish L. Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope. 2004; 114(11):1895-905. PMID: 15510011
12. Nakayama T, Yoshikawa M, Asaka D, Okushi T, Matsuwaki Y, Otori N, et al. Mucosal eosinophilia and recurrence of nasal polyps - new classification of chronic rhinosinusitis. Rhinology. 2011; 49(4):392-6. PMID: 21991563
13. Ikeda K, Shiozawa A, Ono N, Kusunoki T, Hirotsu M, Homma H, et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil. Laryngoscope. 2013; 123(11):E1-9. doi: 10.1002/lary.24154 PMID: 23670893
14. Derycke L, Eyerich S, Van Crombruggen K, Perez-Novo C, Holtappels G, Deruyck N, et al. Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps. PloS one. 2014; 9(6):e97581. doi: 10.1371/journal.pone.0097581 PMID: 24911279
15. Shi LL, Xiong P, Zhang L, Cao PP, Liao B, Lu X, et al. Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns. Allergy. 2013; 68(1):101-9. doi: 10.1111/all.12064 PMID: 23157215
16. Van Bruaene N, Bachert C. Tissue remodeling in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2011; 11(1):8-11. PMID: 21150430
17. Bachert C, Zhang N. Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'. J Intern Med. 2012; 272(2):133-43. doi: 10.1111/j.1365-2796.2012.02559.x PMID: 22640264
18. Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol. 2011; 128 (5):989-95 e1-8. doi: 10.1016/j.jaci.2011.07.056 PMID: 21958585
19. Han JK. Subclassification of chronic rhinosinusitis. Laryngoscope. 2013; 123 Suppl 2:S15-27. doi: 10. 1002/lary.23979 PMID: 23371324
20. Mahdavinia M, Suh LA, Carter RG, Stevens WW, Norton JE, Kato A, et al. Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia. J Allergy Clin Immunol. 2015; 135(2):576-9. doi: 10.1016/j.jaci.2014.08.031 PMID: 25312761
21. Diaz-Vazquez C, Torregrosa-Bertet MJ, Carvajal-Uruena I, Cano-Garcinuno A, Fos-Escriva E, Garcia-Gallego A, et al. Accuracy of ImmunoCAP Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing: the IReNE study. Pediatr Allergy Immunol. 2009; 20 (6):601-9. doi: 10.1111/j.1399-3038.2008.00827.x PMID: 19220775
22. Lund VJ, Kennedy DW. Staging for rhinosinusitis. Otolaryngol Head Neck. 1997; 117(3 Pt 2):S35-40.
23. Kim DW, Kim JY, Kim SW, Jeon SY. Postoperative olfactory results in chronic rhinosinusitis with nasal polyposis according to wound healing status. Clin Exp Otorhinolaryngol. 2013; 6(3):146-51. doi: 10.3342/ceo.2013.6.3.146 PMID: 24069517
24. Kim DK, Park MH, Chang DY, Eun KM, Shin HW, Mo JH, et al. MBP-positive and CD11c-positive cells are associated with different phenotypes of Korean patients with non-asthmatic chronic rhinosinusitis. PloS one. 2014; 9(10):e111352. doi: 10.1371/journal.pone.0111352 PMID: 25361058
25. Ragab A, Clement P, Vincken W. Correlation between the cytology of the nasal middle meatus and BAL in chronic rhinosinusitis. Rhinology. 2005; 43(1):11-7. PMID: 15844496
26. Kim JW, Hong SL, Kim YK, Lee CH, Min YG, Rhee CS. Histological and immunological features of noneosinophilic nasal polyps. Otolaryngol Head Neck. 2007; 137(6):925-30.
27. Jeong WJ, Lee CH, Cho SH, Rhee CS. Eosinophilic allergic polyp: a clinically oriented concept of nasal polyp. Otolaryngol Head Neck. 2011; 144(2):241-6.
28. Yamada T, Fujieda S, Mori S, Yamamoto H, Saito H. Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage. Am J Rhinol. 2000; 14(3):143-8.PMID: 10887619
29. Haruna S, Shimada C, Ozawa M, Fukami S, Moriyama H. A study of poor responders for long-term, low-dose macrolide administration for chronic sinusitis. Rhinology. 2009; 47(1):66-71. PMID: 19382498
30. Alatas N, Baba F, San I, Kurcer Z. Nasal polyp diseases in allergic and nonallergic patients and steroid therapy. Otolaryngol Head Neck. 2006; 135(2):236-42.
31. Kanai N, Denburg J, Jordana M, Dolovich J. Nasal polyp inflammation. Effect of topical nasal steroid. Am J Respir Crit Care Med. 1994; 150(4):1094-100. PMID: 7921442
32. Basinski TM, Holzmann D, Eiwegger T, Zimmermann M, Klunker S, Meyer N, et al. Dual nature of T cell-epithelium interaction in chronic rhinosinusitis. The J Allergy Clin Immunol. 2009; 124(1):74-80 e1-8. doi: 10.1016/j.jaci.2009.04.019 PMID: 19523671
33. Richer SL, Truong-Tran AQ, Conley DB, Carter R, Vermylen D, Grammer LC, et al. Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol. 2008; 22(3):228-34. doi: 10.2500/ajr.2008.22.3162 PMID: 18588753
34. Cho JS, Moon YM, Park IH, Um JY, Moon JH, Park SJ, et al. Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts. Clin Exp Allergy. 2012; 42(6):872-82. doi: 10.1111/j.1365-2222.2011.03931.x PMID: 22239687
35. Sakuma Y, Ishitoya J, Komatsu M, Shiono O, Hirama M, Yamashita Y, et al. New clinical diagnostic criteria for eosinophilic chronic rhinosinusitis. Auris Nasus Larynx. 2011; 38(5):583-8. PMID: 21371840
36. Snidvongs K, McLachlan R, Chin D, Pratt E, Sacks R, Earls P, et al. Osteitic bone: a surrogate marker of eosinophilia in chronic rhinosinusitis. Rhinology. 2012; 50(3):299-305. PMID: 22888488
37. Zuo K, Guo J, Chen F, Xu R, Xu G, Shi J, et al. Clinical characteristics and surrogate markers of eosinophilic chronic rhinosinusitis in Southern China. Eur Arch Otorhinolaryngol. 2014; 271(9):2461-8. doi: 10.1007/s00405-014-2910-0 PMID: 24493563
38. Hu Y, Cao PP, Liang GT, Cui YH, Liu Z. Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults. Laryngoscope. 2012; 122(3):498-503. doi: 10.1002/lary.22507 PMID: 22252861