Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are aßociated with poor outcome

Blood

Volumn 126, Issue 14, 2015, Pages 1723-1728

  Weber, Daniela ^a   Oefner, Peter J ^b   Hiergeist, Andreas ^c   Koestler, Josef ^c   Geßner, Andre ^c   Weber, Markus ^a   Hahn, Joachim ^a   Wolff, Daniel ^a   Stämmler, Frank ^b   Spang, Rainer ^b   Herr, Wolfgang ^a   Dettmer, Katja ^b   Holler, Ernst ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c Institute of Clinical Microbiology and Hygiene   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CIPROFLOXACIN; INDICAN; METRONIDAZOLE; RIFAXIMIN; RNA 16S; NOD2 PROTEIN, HUMAN;

ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; ASEPSIS; BACILLI; CLOSTRIDIA; GASTROINTESTINAL DECONTAMINATION; GASTROINTESTINAL GRAFT VERSUS HOST DISEASE; GENOTYPE; GRAFT VERSUS HOST REACTION; HEPATORENAL SYNDROME; HUMAN; INFLAMMATION; INTESTINE FLORA; INTESTINE MUCOSA; LACHNOSPIRACEAE; LIQUID CHROMATOGRAPHY; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MORTALITY; NEXT GENERATION SEQUENCING; OVERALL SURVIVAL; PRIORITY JOURNAL; RISK FACTOR; RNA GENE; RUMINOCOCCACEAE; SEPTICEMIA; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME; URINARY EXCRETION; URINE LEVEL; ADVERSE EFFECTS; AGED; ALLOGRAFT; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; KAPLAN MEIER METHOD; MALE; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; REVERSED PHASE LIQUID CHROMATOGRAPHY; URINE;

ADULT; AGED; ALLOGRAFTS; CHROMATOGRAPHY, REVERSE-PHASE; FEMALE; GASTROINTESTINAL MICROBIOME; GENOTYPE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INDICAN; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NOD2 SIGNALING ADAPTOR PROTEIN; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84947996079     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-04-638858     Document Type: Article

References (34)

1. Ferrara JL, Levine JE, Reddy P, Holler E. Graftversus- host disease. Lancet. 2009; 373 (9674): 1550-1561.
2. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486 (7402): 207-214.
3. Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504 (7480): 451-455.
4. Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013; 341 (6145): 569-573.
5. Jenq RR, Ubeda C, Taur Y, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med. 2012; 209 (5): 903-911.
6. Holler E, Butzhammer P, Schmid K, et al. Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loß of diversity is aßociated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant. 2014; 20 (5): 640-645.
7. Eriguchi Y, Takashima S, Oka H, et al. Graftversus- host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of a-defensins. Blood. 2012; 120 (1): 223-231.
8. Taur Y, Jenq RR, Perales MA, et al. The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood. 2014; 124 (7): 1174-1182.
9. Landfried K, Zhu W, Waldhier MC, et al. Tryptophan catabolism is aßociated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2, 3-dioxygenase. Blood. 2011; 118 (26): 6971-6974.
10. Zhu W, Stevens AP, Dettmer K, et al. Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography-tandem maß spectrometry. Anal Bioanal Chem. 2011; 401 (10): 3249-3261.
11. Holler E, Rogler G, Herfarth H, et al. Both donor and recipient NOD2/CARD15 mutations aßociate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood. 2004; 104 (3): 889-894.
12. Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7 (5): 335-336.
13. Quast C, Prueße E, Yilmaz P, et al. The SILVA ribosomal RNA gene database project: improved data proceßing and web-based tools. Nucleic Acids Res. 2013; 41 (D1): D590-D596.
14. Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010; 33 (1): 1-22.
15. Vanholder R, Schepers E, Pletinck A, Nagler EV, Glorieux G. The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. J Am Soc Nephrol. 2014; 25 (9): 1897-1907.
16. Lee JH, Lee J. Indole as an intercellular signal in microbial communities. FEMS Microbiol Rev. 2010; 34 (4): 426-444.
17. Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013; 39 (2): 372-385.
18. Gordon J, M'Leod JW. Inhibition of bacterial growth by some amino acids and its bearing on the use of tryptic digests as culture media. J Pathol Bacteriol. 1926; 29 (1): 13-25.
19. Tittsler RP, Sandholzer LA. The bacteriostatic action of indole on Gram-negative enteric bacilli and on certain cocci. J Infect Dis. 1935; 57 (1): 64-69.
20. Bansal T, Alaniz RC, Wood TK, Jayaraman A. The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc Natl Acad Sci USA. 2010; 107 (1): 228-233.
21. Hwang YJ, Yun MO, Jeong KT, Park JH. Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to leßen allergic asthma. Toxicol Lett. 2014; 225 (1): 130-138.
22. Jenq R, Taur Y, Devlin S, et al. Intestinal Blautia is aßociated with reduced death from graft-versushost disease. Biol Blood Marrow Transplant. 2015; 21 (8): 1373-1383.
23. Van den Abbeele P, Belzer C, Gooßens M, et al. Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model. ISME J. 2013; 7 (5): 949-961.
24. Kugelberg E. Mucosal immunology: bacteria get T (Reg) cells into shape. Nat Rev Immunol. 2014; 14 (1): 2-3.
25. Aßelin C, Gendron FP. Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis. FEBS Lett. 2014; 588 (22): 4148-4157.
26. Blaser MJ. The microbiome revolution. J Clin Invest. 2014; 124 (10): 4162-4165.
27. Dharmage SC, Lodge CJ, Lowe AJ, Allen KJ. Antibiotics and risk of asthma: a debate that is set to continue. Clin Exp Allergy. 2015; 45 (1): 6-8.
28. Wegienka G, Zoratti E, Johnson CC. The role of the early-life environment in the development of allergic disease. Immunol Allergy Clin North Am. 2015; 35 (1): 1-17.
29. Holler E, Rogler G, Brenmoehl J, et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood. 2006; 107 (10): 4189-4193.
30. Strober W, Asano N, Fuß I, Kitani A, Watanabe T. Cellular and molecular mechanisms underlying NOD2 risk - Aßociated polymorphisms in Crohn's disease. Immunol Rev. 2014; 260 (1): 249-260.
31. Zhang T, DeSimone RA, Jiao X, et al. Host genes related to paneth cells and xenobiotic metabolism are aßociated with shifts in human ileumaßociated microbial composition. PLoS One. 2012; 7 (6): e30044.
32. Kim YG, Shaw MH, Warner N, et al. Cutting edge: Crohn's disease - Aßociated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol. 2011; 187 (6): 2849-2852.
33. Gutiérrez A, Scharl M, Sempere L, et al. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease. Gut. 2014; 63 (2): 272-280.
34. Shono Y, Docampo MD, Peled JU, Perobelli SM, Jenq RR. Intestinal microbiota-related effects on graft-versus-host disease. Int J Hematol. 2015; 101 (5): 428-437.