Myostatin antibody (LY2495655) in older weak fallers: A proof-of-concept, randomised, phase 2 trial

The Lancet Diabetes and Endocrinology

Volumn 3, Issue 12, 2015, Pages 948-957

  Becker, Clemens ^a   Lord, Stephen R ^b   Studenski, Stephanie A ^c   Warden, Stuart J ^d   Fielding, Roger A ^e   Recknor, Christopher P ^f   Hochberg, Marc C ^g   Ferrari, Serge L ^h   Blain, Hubert ⁱ   Binder, Ellen F ^j   Rolland, Yves ^k   Poiraudeau, Serge ^l,m,n   Benson, Charles T ^o   Myers, Stephen L ^o   Hu, Leijun ^o   Ahmad, Qasim I ^o   Pacuch, Kelli R ^o   Gomez, Elisa V ^o   Benichou, Olivier ^o  

^a ROBERT BOSCH HOSPITAL   (Germany)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d INDIANA UNIVERSITY   (United States)

^e TUFTS UNIVERSITY   (United States)

^f United Osteoporosis Centers   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ MONTPELLIER UNIVERSITY HOSPITAL   (France)

^j WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k TOULOUSE UNIVERSITY HOSPITAL   (France)

^l Cochin Hospital ^*  (France)

^m UNIVERSITÉ PARIS DESCARTES   (France)

ⁿ PARIS DESCARTES UNIVERSITY   (France)

^o ELI LILLY AND COMPANY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LANDOGROZUMAB; PLACEBO; MONOCLONAL ANTIBODY; MSTN PROTEIN, HUMAN; MYOSTATIN;

AGED; AMNESIA; ANEMIA; APPLICATION SITE RASH; ARGENTINA; ARTHRALGIA; ARTICLE; ASTHENIA; BONE PAIN; BURNING SENSATION; CHAIR RISE TEST; CONSTIPATION; CONTROLLED STUDY; CONTUSION; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG WITHDRAWAL; DRY SKIN; DYSGEUSIA; DYSPNEA; EAR DISEASE; EPISTAXIS; ERYTHEMA; FALLING; FATIGUE; FEMALE; FRANCE; FUNCTIONAL ASSESSMENT; GASTRITIS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL HYPERMOTILITY; GASTROINTESTINAL SYMPTOM; GERMANY; HEAD INJURY; HEADACHE; HOT FLUSH; HUMAN; HYPERSENSITIVITY; HYPONATREMIA; HYPOXIA; INJECTION SITE BLEEDING; INJECTION SITE CONTUSION; INJECTION SITE EDEMA; INJECTION SITE MASS; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE RASH; INJECTION SITE REACTION; INJECTION SITE WARMTH; LEAN BODY WEIGHT; LIMB PAIN; MAJOR CLINICAL STUDY; MALAISE; MALE; MULTICENTER STUDY; MUSCLE HYPERTONIA; MUSCLE SPASM; MUSCLE STRENGTH; MUSCLE WEAKNESS; MUSCULOSKELETAL PAIN; MUSCULOSKELETAL STIFFNESS; MYALGIA; NAUSEA; OUTCOME ASSESSMENT; OUTPATIENT CARE; PAIN; PARALLEL DESIGN; PAROSMIA; PHASE 2 CLINICAL TRIAL; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PRURITUS; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; RASH; RECTUM HEMORRHAGE; SPRAIN; SWEDEN; TREATMENT DURATION; UNITED STATES; UNSPECIFIED SIDE EFFECT; UPPER ABDOMINAL PAIN; WALKING SPEED; XEROSTOMIA; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; DRUG EFFECTS; GAIT; HAND STRENGTH; IMMUNOLOGY; SKELETAL MUSCLE; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME; VERY ELDERLY;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL, HUMANIZED; DOUBLE-BLIND METHOD; FEMALE; GAIT; HAND STRENGTH; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MYOSTATIN; TREATMENT OUTCOME;

EID: 84947944816     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(15)00298-3     Document Type: Article

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