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Angewandte Chemie - International Edition

Volumn 54, Issue 30, 2015, Pages 8717-8721

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology

(11) Frett, Brendan a,d Carlomagno, Francesca b Moccia, Maria Luisa b Brescia, Annalisa b Federico, Giorgia b Defalco, Valentina b Admire, Brittany a Chen, Zhongzhu a,e Qi, Wenqing c Santoro, Massimo b Li, Hong Yu a,d

a UNIVERSITY OF ARIZONA (United States)

b UNIVERSITY OF NAPLES FEDERICO II (Italy)

c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER (United States)

d Synactix Pharmaceuticals (United States)

e CHONGQING UNIVERSITY OF ARTS AND SCIENCES (China)

Author keywords

inhibitors; kinases; medicinal chemistry; polypharmacology

Indexed keywords

AMINO ACIDS; CELL CULTURE; CORROSION INHIBITORS; ENZYME INHIBITION; PHOSPHORYLATION; TUMORS;

CELL-BASED ASSAYS; KINASE INHIBITORS; KINASES; KINETIC ANALYSIS; MEDICINAL CHEMISTRY; ONCOGENIC PATHWAYS; POLYPHARMACOLOGY; TYROSINE KINASE INHIBITOR;

ENZYMES;

EID: 84947869287 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201501104 Document Type: Article

Times cited : (23)

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