Recent antibiotic use in German acute care hospitals - From benchmarking to improved prescribing and quality care;Antibiotika-Anwendung 2012/13 in 109 deutschen Akutkrankenhäusern

Deutsche Medizinische Wochenschrift

Volumn 140, Issue 23, 2015, Pages e237-e246

  Kern, W V ^a   Fellhauer, M ^b   Hug, M ^a   Hoppe Tichy, T ^c   Forst G ^a   Steib Bauert, M ^a   De With, K ^d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b SCHWARZWALD BAAR KLINIKUM   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

antibacterial resistance; antibiotic consumption; Antibiotic stewardship; pharmacoepidemiology; quality improvement

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ARTICLE; DRUG USE; GERMAN (CITIZEN); HEALTH CARE QUALITY; HOSPITAL; PRESCRIPTION; QUALITY CONTROL; CLINICAL TRIAL; DRUG UTILIZATION; EPIDEMIOLOGY; GERMANY; HOSPITAL PHARMACY; HOSPITALIZATION; MULTICENTER STUDY; STATISTICS AND NUMERICAL DATA; TOTAL QUALITY MANAGEMENT; UTILIZATION;

ANTI-BACTERIAL AGENTS; BENCHMARKING; DRUG PRESCRIPTIONS; DRUG UTILIZATION; DRUG UTILIZATION REVIEW; GERMANY; HOSPITALIZATION; PHARMACY SERVICE, HOSPITAL; QUALITY IMPROVEMENT;

EID: 84947785254     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0041-105938     Document Type: Article

References (40)

1. Michael C. A.; Dominey-Howes D.; Labbate M. The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health: 2014; 2 145
2. You Y.; Silbergeld E. K. Learning from agriculture: understanding low-dose antimicrobials as drivers of resistome expansion. Front Microbiol: 2014; 5 284
3. European Centre for Disease Prevention and Control Surveillance of antimicrobial consumption in Europe 2012. Stockholm ECDC: 2014; http://ecdc.europa.eu/en/publications/-layouts/forms/Publication-DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=1174 Letzter Zugriff am 27.10.2015
4. ECDC / EFSA / EMA First joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals - Joint Interagency Antimicrobial Consumption and Resistance Analysis (JIACRA). http://www.ema.europa.eu/docs/en-GB/document-library/Report/2015/01/WC500181485.pdf Letzter Zugriff am 27.10.2015
5. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit Hrsg. GERMAP 2008 - Antibiotika-Resistenz und -Verbrauch. http://www.bvl.bund.de/SharedDocs/Downloads/08-PresseInfothek/Germap-2008.pdf?-blob=publicationFile&v=2 Letzter Zugriff am 27.10.2015
6. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit Hrsg. GERMAP 2010 - Antibiotika-Resistenz und -Verbrauch. http://www.bvl.bund.de/SharedDocs/Downloads/08-PresseInfothek/Germap-2010.pdf?-blob=publicationFile&v=2 Letzter Zugriff am 27.10.2015
7. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit Hrsg. GERMAP 2012 - Antibiotika-Resistenz und -Verbrauch. http://www.bvl.bund.de/SharedDocs/Downloads/05-Tierarzneimittel/germap2012.pdf?-blob=publicationFile&v=4 Letzter Zugriff am 27.10.2015
8. Statens Serum Institut, National Veterinary Institute, Technical University of Denmark, National Food Institute, Technical University of Denmark Hrsg. DANMAP 2013. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark. http://www.danmap.org/~/media/Projekt%20sites/Danmap/DANMAP%20reports/DANMAP%202013/DANMAP%202013.ashx Letzter Zugriff am 27.10.2015
9. Vander Stichele R. H.; Elseviers M. M.; Ferech M. et al. Hospital consumption of antibiotics in 15 European countries: results of the ESAC Retrospective Data Collection (1997-2002). J Antimicrob Chemother: 2006; 58 159 167
10. van Boeckel T. P.; Gandra S.; Ashok A. et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis: 2014; 14 742 750
11. van Kleef E.; Robotham J. V.; Jit M. et al. Modelling the transmission of healthcare associated infections: a systematic review. BMC Infect Dis: 2013; 13 294
12. Davis G. S.; Sevdalis N.; Drumright L. N. Spatial and temporal analyses to investigate infectious disease transmission within healthcare settings. J Hosp Infect: 2014; 86 227 243
13. Deutschen Gesellschaft für Infektiologie S3-Leitinie Strategien zur Sicherung rationaler Antibiotika-Anwendung im Krankenhaus. - AWMF-Registernummer 092/001. http://www.awmf.org/uploads/tx-szleitlinien/092-001l-S3-Antibiotika-Anwendung-im- Krankenhaus-2013-12.pdf Letzter Zugriff am 27.10.2015
14. Johannsson B.; Beekmann S. E.; Srinivasan A. et al. Improving antimicrobial stewardship: the evolution of programmatic strategies and barriers. Infect Control Hosp Epidemiol: 2011; 32 367 374
15. Hamilton K. W.; Fishman N. O. Antimicrobial stewardship interventions: thinking inside and outside the box. Infect Dis Clin North Am: 2014; 28 301 313
16. de With K.; Meyer E.; Steib-Bauert M. et al. Antibiotic use in two cohorts of German intensive care units. J Hosp Infect: 2006; 64 231 237
17. de With K.; Bestehorn H.; Steib-Bauert M.; Kern W. V. Comparison of defined versus recommended versus prescribed daily doses for measuring hospital antibiotic consumption. Infection: 2009; 37 349 352
18. Muller A.; Monnet D. L.; Talon D. et al. Discrepancies between prescribed daily doses and WHO defined daily doses of antibacterials at a university hospital. Br J Clin Pharmacol: 2006; 61 585 591
19. Mandy B.; Koutny E.; Cornette C. et al. Methodological validation of monitoring indicators of antibiotics use in hospitals. Pharm World Sci: 2004; 26 90 95
20. Gagliotti C.; Ricchizzi E.; Buttazzi R. et al. Hospital statistics for antibiotics: defined versus prescribed daily dose. Infection: 2014; 42 869 873
21. Haug J. B.; Reikvam Å. WHO defined daily doses versus hospital-adjusted defined daily doses: impact on results of antibiotic use surveillance. J Antimicrob Chemother: 2013; 68 2940 2947
22. Behnke M.; Hansen S.; Leistner R. et al. Nosocomial infection and antibiotic use: a second national prevalence study in Germany. Dtsch Arztebl Int: 2013; 110 627 633
23. Hansen S.; Sohr D.; Piening B. et al. Antibiotic usage in German hospitals: results of the second national prevalence study. J Antimicrob Chemother: 2013; 68 2934 2939
24. NethMap 2014 - Consumption of antimicrobial agents and antimicrobial resistance among medically important bacteria in The Netherlands in 2013. http://www.swab.nl/swab/cms3.nsf/uploads/05ABE3EF93A82F4BC1257D07001DE8BC/FILE/Boek%20Nethmap-MARAN%202014%20TG.pdf Letzter Zugriff am 27.10.2015
25. Dumartin C.; L'Hériteau F.; Péfau M. et al. Antibiotic use in 530 French hospitals: results from a surveillance network at hospital and ward levels in 2007. J Antimicrob Chemother: 2010; 65 2028 2036
26. Dumartin C.; Rogues A. M.; L'Hériteau F. et al. Consommation d'antibiotiques dans les établissements de santé français, réseau ATB-Raisin, 2008-2010. Bulletin Epidémiologique Hebdomadaire: 2012; 42-43 486 490
27. Institut de veille sanitaire Surveillance de la consommation des antibiotiques ATB-Raisin - Synthèse des données 2012. http://www.invs.sante.fr/content/download/87329/320425/version/3/file/Rapport-surveillance-consommation-antibiotiques-atb-raisin-2012.pdf Letzter Zugriff am 27.10.2015
28. SWEDRES-SVARM 2013. Use of antimicrobials and occurrence of antimicrobial resistance in Sweden. http://www.sva.se/globalassets/redesign2011/pdf/om-sva/publikationer/swedres-svarm2013.pdf Letzter Zugriff am 2.11.2015
29. Feazel L. M.; Malhotra A.; Perencevich E. N. et al. Effect of antibiotic stewardship programmes on Clostridium difficile incidence: a systematic review and meta-analysis. J Antimicrob Chemother: 2014; 69 1748 1754
30. Gbaguidi-Haore H.; Dumartin C.; L'Hériteau F. et al. Antibiotics involved in the occurrence of antibiotic-resistant bacteria: a nationwide multilevel study suggests differences within antibiotic classes. J Antimicrob Chemother: 2013; 68 461 470
31. McKinnell J. A.; Kunz D. F.; Chamot E. et al. Association between vancomycin-resistant Enterococci bacteremia and ceftriaxone usage. Infect Control Hosp Epidemiol: 2012; 33 718 724
32. Hayakawa K.; Marchaim D.; Palla M. et al. Epidemiology of vancomycin-resistant Enterococcus faecalis: a case-case-control study. Antimicrob Agents Chemother: 2013; 57 49 55
33. Pereira J. B.; Farragher T. M.; Tully M. P.; Cooke J. Association between Clostridium difficile infection and antimicrobial usage in a large group of English hospitals. Br J Clin Pharmacol: 2014; 77 896 903
34. Cooke J.; Stephens P.; Ashiru-Oredope D. et al. Longitudinal trends and cross-sectional analysis of English national hospital antibacterial use over 5 years (2008-13): working towards hospital prescribing quality measures. J Antimicrob Chemother: 2015; 70 279 285
35. Weber S. G.; Gold H. S.; Hooper D. C. et al. Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis: 2003; 9 1415 1422
36. LeBlanc L.; Pépin J.; Toulouse K. et al. Fluoroquinolones and risk for methicillin-resistant Staphylococcus aureus, Canada. Emerg Infect Dis: 2006; 12 1398 1405
37. Schneider-Lindner V.; Delaney J. A.; Dial S. et al. Antimicrobial drugs and community-acquired methicillin-resistant Staphylococcus aureus, United Kingdom. Emerg Infect Dis: 2007; 13 994 1000
38. Boussat S.; Demoré B.; Lozniewski A. et al. How to improve the collection and analysis of hospital antibiotic consumption: preliminary results of the ConsoRes software experimental implementation. Med Mal Infect: 2012; 42 154 160
39. Gravatt L. A.; Pakyz A. L. Challenges in measuring antibiotic consumption. Curr Infect Dis Rep: 2013; 15 559 563
40. Schweickert B.; Kern W. V.; de With K. et al. Antibiotika-Verbrauchs-Surveillance. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz: 2013; 56 903 912