Anti-hyperglycaemic effects of herbal porridge made of Scoparia dulcis leaf extract in diabetics - a randomized crossover clinical trial

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Senadheera, Senadheera Pathirannehelage Anuruddhika Subhashinie ^a   Ekanayake, Sagarika ^a   Wanigatunge, Chandanie ^a  

^a UNIVERSITY OF SRI JAYEWARDENEPURA   (Sri Lanka)

Author keywords

Anti hyperglycaemic; Cholesterol; Leafy porridge; Scoparia dulcis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATININE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UREA; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

ADULT; AGED; ANTIDIABETIC ACTIVITY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSSOVER PROCEDURE; DIABETIC DIET; FEMALE; FOOD; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HIGH RISK PATIENT; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; PORRIDGE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SCOPARIA DULCIS; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CHEMISTRY; DIABETES MELLITUS; DIET THERAPY; DRUG EFFECTS; FOOD GRAIN; HYPERGLYCEMIA; MEDICINAL PLANT; MIDDLE AGED; ORYZA; PHYTOTHERAPY; RAT; SCOPARIA; WISTAR RAT;

ADULT; AGED; ANIMALS; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIABETES MELLITUS; EDIBLE GRAIN; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; ORYZA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SCOPARIA;

EID: 84947741598     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0935-6     Document Type: Article

References (21)

1. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007;40(3):163-73.
2. Das H, Chakraborty U. Anti-hyperglycemic effect of Scoparia dulcis in streptozotocin induced diabetes. Res J Pharm Biol Chem Sci. 2011;2(2):334-42.
3. Chawla R, Thakur P, Chowdhry A, Jaiswal S, Sharma A, Goel R, et al. Evidence based herbal drug standardization approach in coping with challenges of holistic management of diabetes: a dreadful lifestyle disorder of 21st century. J Diab Metabol Disord. 2013;12:35.
4. Sweet Broomweed. Available at: http://www.drugs.com/npp/sweet-broomweed.html. Accessed on 23/11/2014.
5. Choudhury RP, Garg AN. Variation in essential, trace and toxic elemental contents in Murraya koenigii - A spice and medicinal herb from different Indian states. Food Chem. 2007;104(4):1454-63.
6. Veeramani C, Pushpavalli G, Pugalendi KV. Antihyperglycaemic effect of Cardiospermum halicacabum Linn. leaf extract on STZ-induced diabetic rats. J Appl Biomed. 2008;6(1):19-26.
7. Senadheera SPAS, Ekanayake S. Development of a herbal leafy porridge from Scoparia dulcis. J Agric Sci. 2013;4(9B):81-4.
8. Senadheera SPAS, Ekanayake S, Wanigatunge C. Anti-diabetic properties of rice based herbal porridges in diabetic Wistar rats. Phytother Res. 2014;28(10):1567-72. doi: 10.1002/ptr.5169.
9. Pari L, Latha M. Antidiabetic effect of Scoparia dulcis: Effect of lipid peroxidation in streptozotocin diabetes. Gen Physiol Biophys. 2005;24:13-26.
10. Pari L, Latha M. Antihyperlipidemic effect of Scoparia dulcis (Sweet Broomweed) in streptozotocin diabetic rats. J Med Food. 2006;9(1):102-7. doi: 10.1089/jmf.2006.9.102.
11. Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009;5:757-65.
12. Real JT, Chaves FJ, Martínez-Usó I, García-García AB, Ascaso JF, Carmena R. Importance of HDL cholesterol levels and the total/ HDL cholesterol ratio as a risk factor for coronary heart disease in molecularly defined heterozygous familial hypercholesterolaemia. Eur Heart J. 2001;22(6):465-71.
13. Dobiasova M. Atherogenic Index of Plasma [Log (Triglycerides/HDL-Cholesterol)]: Theoretical and Practical Implications. Clin Chem. 2004;50(7):1113-15.
14. Shanmugapriya V, Mohanty PK, Anil KD. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. 2013;2(4):1063-67. doi: 10.5455/ijmsph.2013.010920132.
15. Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Br Med J. 2000;321:405-12. doi: 10.1136/bmj.321.7258.405.
16. Latha M, Pari L, Sitasawad S, Bhonde R. Scoparia dulcis, a traditional antidiabetic plant, protects against streptozotocin induced oxidative stress and apoptosis in vitro and in vivo. J Biochem Mol Toxic. 2004;18(5):261-72.
17. Beh JE, Latip J, Abdullah MP, Ismail A, Hamid M. Scoparia dulcis (SDF7) endowed with glucose uptake properties on L6 myotubes compared insulin. J Ethnopharmacol. 2010;129(1):23-33.
18. Pari L, Latha M. Antihyperglycaemic effect of Scoparia dulcis.: effect on key metabolic enzymes of carbohydrate metabolism in streptozotocin-induced diabetes. Pharm Biol. 2005;42(8):570-76.
19. Bitzur R, Cohen H, Kamari Y, Shaish A, Harats D. Triglycerides and HDL cholesterol stars or second leads in diabetes? Diabetes Care. 2009;32(2):S373-7.
20. Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004;53(3):693-700.
21. Mugabo Y, Li L, Renier G. The connection between C-reactive protein (CRP) and diabetic vasculopathy. Focus on preclinical findings. Curr Diabetes Rev. 2010;6(1):27-34.