What is myeloperoxidase doing in ANCA-associated glomerulonephritis¿

Kidney International

Volumn 88, Issue 5, 2015, Pages 938-940

  Couser, William G ^a   Johnson, Richard J ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; ENZYME ANTIBODY; HALIDE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G; MYELOPEROXIDASE; MYELOPEROXIDASE ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; UNCLASSIFIED DRUG; PEROXIDASE;

ANCA ASSOCIATED VASCULITIS; ANTI NEUTROPHIL CYTOPLASMIC ANTIBODY ASSOCIATED GLOMERULONEPHRITIS; AUTOIMMUNITY; CELL MEMBRANE; ENZYME LOCALIZATION; GLOMERULONEPHRITIS; HALOGENATION; HUMAN; KIDNEY INJURY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; IMMUNOLOGY;

ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; GLOMERULONEPHRITIS; HUMANS; HYDROGEN PEROXIDE; PEROXIDASE;

EID: 84947610338     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.259     Document Type: Note

References (9)

1. O'Sullivan KM, Lo CY, Summers SA et al. Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Kidney Int 2015; 88: 1030-1046.
2. Jennette JC, Falk RJ. B cell-mediated pathogenesis of ANCA-mediated vasculitis. Semin Immunopathol 2014;36: 327-338.
3. Stilmant MM, Bolton WK, Sturgill BC et al. Crescentic glomerulonephritis without immune deposits: clinicopathologic features. Kidney Int 1979;15: 184-195.
4. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-1657.
5. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002;110: 955-963.
6. Ooi JD, Gan PY, Odobasic D et al. T cell mediated autoimmune glomerular disease in mice. Curr Protoc Immunol 2014;107: 15. 27. 11-15. 27. 19.
7. Ruth AJ, Kitching AR, Kwan RY et al. Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulo-nephritis. J Am Soc Nephrol 2006; 17:1940-1949.
8. Johnson RJ, Couser WG, Chi EY et al. New mechanism for glomerular injury. Myelo-peroxidase-hydrogen peroxide-halide system. J Clin Invest 1987;79: 1379-1387.
9. Couser WG, Johnson RJ. The etiology of glomerulonephritis: roles of infection and autoimmunity. Kidney Int 2014;86: 905-914.