Pharmacological correction of excitation/inhibition imbalance in down syndrome mouse models

Frontiers in Behavioral Neuroscience

Volumn 9, Issue OCTOBER, 2015, Pages

  Souchet, Benoit ^a   Guedj, Fayçal ^a,b   Penke Verdier, Zsuza ^c   Daubigney, Fabrice ^a   Duchon, Arnaud ^d   Herault, Yann ^d   Bizot, Jean Charles ^e   Janel, Nathalie ^a   Créau, Nicole ^a   Delatour, Benoit ^c   Delabar, Jean M ^a,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b TUFTS MEDICAL CENTER   (United States)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e Centre d'Innovation   (France)

Author keywords

Down syndrome; DYRK1A; EGCG; Excitation inhibition balance; GABA pathway; Glutamate pathway

Indexed keywords

4 AMINOBUTYRIC ACID; CAFFEINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DUAL SPECIFICITY TYROSINE PHOSPHORYLATED AND REGULATED KINASE 1A; EPIGALLOCATECHIN GALLATE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; GREEN TEA EXTRACT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PLACEBO; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DISEASE MODEL; DOWN SYNDROME; DRUG DOSE COMPARISON; DYRK1A GENE; ENZYME INHIBITION; GABAERGIC TRANSMISSION; GENE; GENE OVEREXPRESSION; GLUTAMATERGIC TRANSMISSION; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL INHIBITION; NERVE CELL STIMULATION; NEUROTRANSMISSION; NONHUMAN; PROTEIN EXPRESSION; SYNAPTIC INHIBITION;

EID: 84947585950     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2015.00267     Document Type: Article

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