메뉴 건너뛰기




Volumn 16, Issue 16, 2015, Pages 2531-2538

Lorcaserin Hcl for the treatment of obesity

Author keywords

5HT2C agonist; behavioral modification and lorcaserin for overweight and obesity management; behavioral modification and lorcaserin second study for obesity management; lorcaserin; obesity

Indexed keywords

LORCASERIN; ANTIOBESITY AGENT; BENZAZEPINE DERIVATIVE; SEROTONIN 2 AGONIST;

EID: 84947489689     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2015.1096345     Document Type: Article
Times cited : (26)

References (36)
  • 1
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among us adults, 1999-2010
    • Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among us adults, 1999-2010. JAMA 2012;307(5):291-497
    • (2012) JAMA , vol.307 , Issue.5 , pp. 291-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3
  • 2
    • 0037370258 scopus 로고    scopus 로고
    • The emerging science of body weight regulation and its impact on obesity treatment
    • Korner J, Aronne LJ. The emerging science of body weight regulation and its impact on obesity treatment. J Clin Invest 2003;111(5):565-70
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 565-570
    • Korner, J.1    Aronne, L.J.2
  • 3
    • 1542709732 scopus 로고    scopus 로고
    • Self-regulation of energy intake in the prevention and treatment of obesity: Is it feasible?
    • Lowe M. Self-regulation of energy intake in the prevention and treatment of obesity: is it feasible? Obes Res 2003;11(Suppl):44S-59S
    • (2003) Obes Res , vol.11 , pp. 44S-59S
    • Lowe, M.1
  • 5
    • 0032543870 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group
    • Sjostrom L, Rissanen A, Andersen T, et al. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group. Lancet 1998;352(9123):167-72
    • (1998) Lancet , vol.352 , Issue.9123 , pp. 167-172
    • Sjostrom, L.1    Rissanen, A.2    Andersen, T.3
  • 6
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): A randomised, placebo-controlled, phase 3 trial
    • Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): A randomised, placebo-controlled, phase 3 trial. Lancet 2011;377(9774):1341-52
    • (2011) Lancet , vol.377 , Issue.9774 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3
  • 7
    • 84879324574 scopus 로고    scopus 로고
    • COR-II Study Group A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)
    • Apovian CM, Aronne L, Rubino D, et al. COR-II Study Group A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring) 2013;21(5):935-43
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.5 , pp. 935-943
    • Apovian, C.M.1    Aronne, L.2    Rubino, D.3
  • 9
    • 84929730232 scopus 로고    scopus 로고
    • 5-hydroxytryptamine medications for the treatment of obesity
    • Burke LK and Heisler LK. 5-Hydroxytryptamine Medications for the Treatment of Obesity. J Neuroendocrinol 2015;27:389-98
    • (2015) J Neuroendocrinol , vol.27 , pp. 389-398
    • Burke, L.K.1    Heisler, L.K.2
  • 10
    • 0017260199 scopus 로고
    • Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine
    • Saller CF, Stricker EM. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 1976;192:385-7
    • (1976) Science , vol.192 , pp. 385-387
    • Saller, C.F.1    Stricker, E.M.2
  • 11
    • 0017284150 scopus 로고
    • Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine
    • Breisch ST, Zemlan FP, Hoebel BG. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 1976;192:382-5
    • (1976) Science , vol.192 , pp. 382-385
    • Breisch, S.T.1    Zemlan, F.P.2    Hoebel, B.G.3
  • 12
    • 0030860731 scopus 로고    scopus 로고
    • Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat
    • Jackson HC, Needham AM, Hutchins LJ, et al. Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br J Pharmacol 1997;121:1758-62
    • (1997) Br J Pharmacol , vol.121 , pp. 1758-1762
    • Jackson, H.C.1    Needham, A.M.2    Hutchins, L.J.3
  • 13
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    • Tecott LH, Sun LM, Akana SF, et al. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 1995;374:542-6
    • (1995) Nature , vol.374 , pp. 542-546
    • Tecott, L.H.1    Sun, L.M.2    Akana, S.F.3
  • 14
    • 0034867499 scopus 로고    scopus 로고
    • Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: Comparison with as demonstrted by [3H] mesulergine binding sites and choline acetyltransferase mRNA
    • Lopez-Gimenez JF, Mengod G, Palacios JM, et al. Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with as demonstrted by [3H] mesulergine binding sites and choline acetyltransferase mRNA. Synapse 2001;42:12-26
    • (2001) Synapse , vol.42 , pp. 12-26
    • Lopez-Gimenez, J.F.1    Mengod, G.2    Palacios, J.M.3
  • 15
    • 0033059447 scopus 로고    scopus 로고
    • Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain
    • Pasqualetti M, Ori M, Castagna M, et al. Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 1999;92:601-11
    • (1999) Neuroscience , vol.92 , pp. 601-611
    • Pasqualetti, M.1    Ori, M.2    Castagna, M.3
  • 16
    • 35548942643 scopus 로고    scopus 로고
    • Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    • Zhou L, Sutton GM, Rochford JJ, et al. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab 2007;6:398-405
    • (2007) Cell Metab , vol.6 , pp. 398-405
    • Zhou, L.1    Sutton, G.M.2    Rochford, J.J.3
  • 17
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki K, Strack AM, Dallman MF, et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 1998;4:1152-6
    • (1998) Nat Med , vol.4 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3
  • 18
    • 78650191226 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by proopiomelanocortin neurons regulate insulin sensitivity in liver
    • Xu Y, Berglund ED, Sohn JW, et al. 5-HT2CRs expressed by proopiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci 2010;13:1457-9
    • (2010) Nat Neurosci , vol.13 , pp. 1457-1459
    • Xu, Y.1    Berglund, E.D.2    Sohn, J.W.3
  • 19
    • 84890109255 scopus 로고    scopus 로고
    • Serotonin 2C receptors in proopiomelanocortin neurons regulate energy and glucose homeostasis
    • Berglund ED, Liu C, Sohn JW, et al. Serotonin 2C receptors in proopiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest 2013;123:5061-70
    • (2013) J Clin Invest , vol.123 , pp. 5061-5070
    • Berglund, E.D.1    Liu, C.2    Sohn, J.W.3
  • 20
    • 84879431131 scopus 로고    scopus 로고
    • Lorcaserin: A review of its use in chronic weight management
    • Hoy SM. Lorcaserin: A review of its use in chronic weight management. Drugs 2013;73(5):463-73
    • (2013) Drugs , vol.73 , Issue.5 , pp. 463-473
    • Hoy, S.M.1
  • 21
    • 79952297237 scopus 로고    scopus 로고
    • Lorcaserin, a 5-HT2C receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure
    • Martin CK, Redman LM, Zhang J, et al. Lorcaserin, a 5-HT2C receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure. J Clin Endocrinol Metab 2011;96(3):837-45
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.3 , pp. 837-845
    • Martin, C.K.1    Redman, L.M.2    Zhang, J.3
  • 22
    • 84907222919 scopus 로고    scopus 로고
    • 5-HT obesity medication efficacy via POMC activation is maintained during aging
    • Burke LK, Doslikova B, D'Agostino G, et al. 5-HT obesity medication efficacy via POMC activation is maintained during aging. Endocrinology 2014;155:3732-8
    • (2014) Endocrinology , vol.155 , pp. 3732-3738
    • Burke, L.K.1    Doslikova, B.2    D'Agostino, G.3
  • 25
    • 0030876952 scopus 로고    scopus 로고
    • Valvular heart disease associated with fenfluramine-phentermine
    • Connolly HM, Crary JL, McGoon MD, et al. Valvular Heart Disease Associated with Fenfluramine-Phentermine. NEJM 1997;337(9):581-8
    • (1997) NEJM , vol.337 , Issue.9 , pp. 581-588
    • Connolly, H.M.1    Crary, J.L.2    McGoon, M.D.3
  • 26
    • 36348949470 scopus 로고    scopus 로고
    • Arena Pharmaceuticals announces results of its phase lb safety study for its novel anti-obesity compound
    • Nov 3; [news release]
    • Arena Pharmaceuticals announces results of its phase lb safety study for its novel anti-obesity compound. Arena Pharmaceuticals 2004 Nov 3; [news release]
    • (2004) Arena Pharmaceuticals
  • 27
    • 60849103765 scopus 로고    scopus 로고
    • Lorcaserin (APD356) a selective 5-HT (2C) agonist reduces body weight in obese men and women
    • Smith SR, Prosser WA, Donahue DJ, et al. APD356-004 Study Group. Lorcaserin (APD356) a selective 5-HT (2C) agonist reduces body weight in obese men and women. Obesity (Silver Spring) 2009;17(3):494-503
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.3 , pp. 494-503
    • APD356-004 Study Group1    Smith, S.R.2    Prosser, W.A.3    Donahue, D.J.4
  • 28
    • 77954635020 scopus 로고    scopus 로고
    • Multicenter, placebo-controlled trial of lorcaserin for weight management
    • Smith SR, Weissman NJ, Anderson CM, et al. Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med 2010;363(3):245-56
    • (2010) N Engl J Med , vol.363 , Issue.3 , pp. 245-256
    • Smith, S.R.1    Weissman, N.J.2    Anderson, C.M.3
  • 29
    • 80053539943 scopus 로고    scopus 로고
    • A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: The BLOSSOM trial
    • Fidler MC, Sanchez M, Raether B, et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: The BLOSSOM trial. J Clin Endocrinol Metab 2011;96(10):3067-77
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.10 , pp. 3067-3077
    • Fidler, M.C.1    Sanchez, M.2    Raether, B.3
  • 30
    • 84862869642 scopus 로고    scopus 로고
    • Randomized placebo-controlled clinical trial of. Lorcaserin for weight loss in type 2 diabetes mellitus: The BLOOM-DM study
    • O'Neil P, Smith SR, Weissman NJ, et al. Randomized placebo-controlled clinical trial of. Lorcaserin for weight loss in type 2 diabetes mellitus: The BLOOM-DM study. Obesity 2012;20(7):1426-36
    • (2012) Obesity , vol.20 , Issue.7 , pp. 1426-1436
    • O'Neil, P.1    Smith, S.R.2    Weissman, N.J.3
  • 31
    • 84922392384 scopus 로고    scopus 로고
    • Safety and efficacy of lorcaserin: A combined analysis of the BLOOM and BLOSSOM trials
    • Aronne L, Shanahan W, Fain R, et al. Safety and efficacy of lorcaserin: A combined analysis of the BLOOM and BLOSSOM trials. Postgrad Med 2014;126(6):7-18
    • (2014) Postgrad Med , vol.126 , Issue.6 , pp. 7-18
    • Aronne, L.1    Shanahan, W.2    Fain, R.3
  • 32
    • 84884478505 scopus 로고    scopus 로고
    • Echocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials
    • Weissman NJ, Sanchez M, Koch GG, et al. Echocardiographic assessment of cardiac valvular regurgitation with lorcaserin from analysis of 3 phase 3 clinical trials. Circ Cardiovasc Imaging 2013;6(4):560-7
    • (2013) Circ Cardiovasc Imaging , vol.6 , Issue.4 , pp. 560-567
    • Weissman, N.J.1    Sanchez, M.2    Koch, G.G.3
  • 33
    • 84947497990 scopus 로고    scopus 로고
    • Last accessed 12 July
    • Available from: www.clinicaltrials.gov [Last accessed 12 July 2015]
    • (2015)
  • 34
    • 84907697527 scopus 로고    scopus 로고
    • Early weight loss while on lorcaserin, diet and exercise as a predictor of week 52 weight-loss outcomes
    • Smith SR, O'Neil PM, Astrup A, et al. Early weight loss while on lorcaserin, diet and exercise as a predictor of week 52 weight-loss outcomes. Obesity (Silver Spring) 2014;22(10):2137-46
    • (2014) Obesity (Silver Spring) , vol.22 , Issue.10 , pp. 2137-2146
    • Smith, S.R.1    O'Neil, P.M.2    Astrup, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.