Methods to Prevent Tick Bites and Lyme Disease

Clinics in Laboratory Medicine

Volumn 35, Issue 4, 2015, Pages 883-899

  Ogden, Nick H ^a   Lindsay, L Robbin ^a   Schofield, Steven W ^b  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b DEPARTMENT OF NATIONAL DEFENCE   (Canada)

Author keywords

Ixodes pacificus; Ixodes scapularis; Lyme disease; Personal protection; Repellent

Indexed keywords

BACTERIAL ANTIGEN; DIETHYLTOLUAMIDE; DOXYCYCLINE; ICARIDIN; INSECT REPELLENT; LYME DISEASE VACCINE; OUTER SURFACE PROTEIN A; OUTER SURFACE PROTEIN C; PERMETHRIN; PESTICIDE; UNCLASSIFIED DRUG;

BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BORRELIA BURGDORFERI; DISEASE TRANSMISSION; ENVIRONMENTAL MANAGEMENT; HUMAN; INFECTION RISK; INSECT CONTROL; LANDSCAPE; LYME DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTECTIVE CLOTHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; TICK BITE; VECTOR CONTROL; VEGETATION; ZOONOSIS; ANIMAL; ANTIBIOTIC PROPHYLAXIS; BIOLOGICAL PEST CONTROL; PROCEDURES; TICK; TICK BITES; VACCINATION;

ANIMALS; ANTIBIOTIC PROPHYLAXIS; HUMANS; LYME DISEASE; PEST CONTROL, BIOLOGICAL; TICK BITES; TICKS; VACCINATION;

EID: 84947488714     PISSN: 02722712     EISSN: 15579832     Source Type: Journal    
DOI: 10.1016/j.cll.2015.07.003     Document Type: Review

References (115)

1. Centers for Disease Control and Prevention (CDC). Ticks geographic distribution. Available at:. Accessed April 27, 2015. http://www.cdc.gov/ticks/geographic_distribution.html#blacklegged.
2. Public Health Agency of Canada. Established tick populations in Canada. Available at:. Accessed April 27, 2015. http://www.phac-aspc.gc.ca/id-mi/tickinfo-eng.php.
3. Centers for Disease Control and Prevention (CDC). Lyme disease-data and statistics. Available at:. Accessed April 27, 2015. http://www.cdc.gov/lyme/stats/.
4. Public Health Agency of Canada. National Lyme Disease Surveillance in Canada 2009-2012. Available at:. Accessed April 27, 2015. http://healthycanadians.gc.ca/diseases-conditions-maladies-affections/disease-maladie/lyme/report-rapport-2009-2012-eng.php.
5. Stromdahl E.Y., Hickling G.J. Beyond Lyme: aetiology of tick-borne human diseases with emphasis on the south-eastern United States. Zoonoses Public Health 2012, 59(Suppl 2):48-64.
6. Leighton P.A., Koffi J.K., Pelcat Y., et al. Predicting the speed of tick invasion: an empirical model of range expansion for the Lyme disease vector Ixodes scapularis in Canada. J Appl Ecol 2012, 49(2):457-464.
7. Ogden N.H., Lindsay L.R., Leighton P.A. Predicting the rate of invasion of the agent of Lyme disease Borrelia burgdorferi. J Appl Ecol 2013, 50(2):510-518.
8. Poland G.A. Vaccines against Lyme disease: what happened and what lessons can we learn?. Clin Infect Dis 2011, 52(Suppl 3):s253-s258.
9. Hayes E.B., Maupin G.O., Mount G.A., et al. Assessing the prevention effectiveness of local Lyme disease control. J Public Health Manag Pract 1999, 5(3):84-92.
10. Poland G.A. Prevention of Lyme disease: a review of the evidence. Mayo Clin Proc 2001, 76(7):713-724.
11. Corapi K.M., White M.I., Phillips C.B., et al. Strategies for primary and secondary prevention of Lyme disease. Nat Clin Pract Rheumatol 2007, 3(1):20-25.
12. Piesman J., Eisen L. Prevention of tick-borne diseases. Annu Rev Entomol 2008, 53:323-343.
13. Piesman J., Beard C.B. Prevention of tick-borne diseases. J Environ Health 2012, 74(10):30-32.
14. Ogden N.H., Trudel L., Artsob H., et al. Ixodes scapularis ticks collected by passive surveillance in Canada: analysis of geographic distribution and infection with Lyme borreliosis agent Borrelia burgdorferi. J Med Entomol 2006, 43(3):600-609.
15. Ogden N.H., Lindsay L.R., Morshed M., et al. The emergence of Lyme disease in Canada. CMAJ 2009, 180(12):1221-1224.
16. Ogden N.H., Koffi J.K., Pelcat Y., et al. Environmental risk from Lyme disease in central and eastern Canada: a summary of recent surveillance information. Can Commun Dis Rep 2014, 40(5):74-82.
17. Lindsay L.R., Mathison S.W., Barker I.K., et al. Microclimate and habitat in relation to Ixodes scapularis (Acari: Ixodidae) populations on Long Point, Ontario, Canada. J Med Entomol 1999, 36(3):255-262.
18. Guerra M., Walker E., Jones C., et al. Predicting the risk of Lyme disease: habitat suitability for Ixodes scapularis in the north central United States. Emerg Infect Dis 2002, 8(3):289-297.
19. Smith R.P. Ticks: the vectors of Lyme disease. Lyme disease: an evidence based approach 2011, 1-28. CABI, Wallingford (CT); Oxfordshire (United Kingdom). J.J. Halperin (Ed.).
20. Maupin G.O., Fish D., Zultowsky J., et al. Landscape ecology of Lyme disease in a residential area of Westchester County, New York. Am J Epidemiol 1991, 133(11):1105-1113.
21. Carroll M.C., Ginsberg H.S., Hyland K.E., et al. Distribution of Ixodes dammini (Acari: Ixodidae) in residential lawns on Prudence Island, Rhode Island. J Med Entomol 1992, 29(6):1052-1055.
22. Duffy D.C., Clark D.D., Campbell S.R., et al. Landscape patterns of abundance of Ixodes scapularis (Acari: Ixodidae) on Shelter Island, New York. J Med Entomol 1994, 31(6):875-879.
23. Piesman J., Humair P. The spirochetes and vector ticks of Lyme borreliosis in nature. Lyme Borreliosis in Europe and North America: epidemiology and clinical practice 2011, 37-51. John Wiley & Sons, Inc, Hoboken (NJ). S.K. Sood (Ed.).
24. Diuk-Wasser M.A., Hoen A.G., Cislo P., et al. Human risk of infection with Borrelia burgdorferi, the Lyme disease agent, in eastern United States. Am J Trop Med Hyg 2012, 86(2):320-327.
25. Eisen R.J., Piesman J., Zielinski-Gutierrez E., et al. What do we need to know about disease ecology to prevent Lyme disease in the northeastern United States?. J Med Entomol 2012, 49(1):11-22.
26. Ogden N.H., Lindsay L.R., Hanincová K., et al. Role of migratory birds in introduction and range expansion of Ixodes scapularis ticks and of Borrelia burgdorferi and Anaplasma phagocytophilum in Canada. Appl Environ Microbiol 2008, 74(6):1780-1790.
27. Rodgers S.E., Miller N.J., Mather T.N. Seasonal variation in nymphal blacklegged tick abundance in southern New England forests. J Med Entomol 2007, 44(5):898-900.
28. Bacon R.M., Kugeler K.J., Mead P.S., et al. Surveillance for Lyme disease-United States, 1992-2006. MMWR Surveill Summ 2008, 57(10):1-9.
29. Falco R.C., Fish D., Piesman J. Duration of tick bites in a Lyme disease-endemic area. Am J Epidemiol 1996, 143(2):187-192.
30. Clark R.P., Hu L.T. Prevention of Lyme disease and other tick-borne infections. Infect Dis Clin North Am 2008, 22(3):381-396.
31. Duffy D.C., Campbell S.R. Ambient air temperature as a predictor of activity of adult Ixodes scapularis (Acari: Ixodidae). J Med Entomol 1994, 31(1):178-180.
32. Vázquez M., Muehlenbein C., Cartter M., et al. Effectiveness of personal protective measures to prevent Lyme disease. Emerg Infect Dis 2008, 14(2):210-216.
33. Schofield S., Plourde P. Statement on personal protective measures to prevent arthropod bites. An Advisory Committee Statement (ACS). Can Commun Dis Rep 2012, 38(ACS-3):1-18.
34. Centers for Disease Control and Prevention (CDC). Preventing tick bites. Available at:. Accessed April 27, 2015. http://www.cdc.gov/lyme/prev/index.html.
35. Health Canada. Pest Management Regulatory Agency. Insect Repellents. Available at:. Accessed April 27, 2015. http://www.healthycanadians.gc.ca/environment-environnement/pesticides/insect_repellents-insectifuges-eng.php.
36. Health Canada. Pest Management Regulatory Agency. ARCHIVED - Memo - DEET (N,N-diethyl-m-toluamide) Statement of Guarantee and Labelling Allowances. Available at:. Accessed April 27, 2015. http://www.hc-sc.gc.ca/cps-spc/pest/registrant-titulaire/prod/_memo-note/deet-eng.php.
37. Carroll S.P. Prolonged efficacy of IR3535 repellents against mosquitoes and blacklegged ticks in North America. J Med Entomol 2008, 45(4):706-714.
38. Cisak E., Wojcik-Fatla A., Zajac V., et al. Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases. Ann Agric Environ Med 2012, 19(4):625-630.
39. Pages F., Dautel H., Duvallet G., et al. Tick repellents for human use: prevention of tick bites and tick-borne diseases. Vector Borne Zoonotic Dis 2014, 14(2):85-93.
40. Carroll J.F., Kramer M. Different activities and footwear influence exposure to host-seeking nymphs of Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae). J Med Entomol 2001, 38(4):596-600.
41. Stjernberg L., Berglund J. Detecting ticks on light versus dark clothing. Scand J Infect Dis 2005, 37(5):361-364.
42. Carroll J.F. A cautionary note: survival of nymphs of two species of ticks (Acari: Ixodidae) among clothes laundered in an automatic washer. J Med Entomol 2003, 40(5):732-736.
43. Evans S.R., Korch G.W., Lawson M.A. Comparative field evaluation of permethrin and DEET-treated military uniforms for personal protection against ticks (Acari). J Med Entomol 1990, 27(5):829-834.
44. Miller N.J., Rainone E.E., Dyer M.C., et al. Tick bite protection with permethrin-treated summer-weight clothing. J Med Entomol 2011, 48(2):327-333.
45. Vaughn M.F., Meshnick S.R. Pilot study assessing the effectiveness of long-lasting permethrin-impregnated clothing for the prevention of tick bites. Vector Borne Zoonotic Dis 2011, 11(7):869-875.
46. Faulde M.K., Rutenfranz M., Keth A., et al. Pilot study assessing the effectiveness of factory-treated, long-lasting permethrin-impregnated clothing for the prevention of tick bites during occupational tick exposure in highly infested military training areas, Germany. Parasitol Res 2015, 114(2):671-678.
47. Vaughn M.F., Funkhouser S.W., Lin F.C., et al. Long-lasting permethrin impregnated uniforms: a randomized-controlled trial for tick bite prevention. Am J Prev Med 2014, 46(5):473-480.
48. Nasci RS, Zielinski-Gutierrez E, Wirtz RA, et al. CDC Yellow Book: Chapter 2-Protection against mosquitoes, ticks and other insects and arthropods. Available at:. Accessed April 27, 2015. http://wwwnc.cdc.gov/travel/yellowbook/2014/chapter-2-the-pre-travel-consultation/protection-against-mosquitoes-ticks-and-other-insects-and-arthropods.
49. Connally N.P., Durante A.J., Yousey-Hindes K.M., et al. Peridomestic Lyme disease prevention. Results of a population-based case-control study. Am J Prev Med 2009, 37(3):201-206.
50. Nadelman R.B., Nowakowski J., Fish D., et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001, 345(2):79-84.
51. Mowbray F., Amlot R., Rubin G.J. Predictors of protective behaviour against ticks in the UK: a mixed methods study. Ticks Tick Borne Dis 2014, 5(4):392-400.
52. Needham G.R. Evaluation of five popular methods for tick removal. Pediatrics 1985, 75(6):997-1002.
53. Piesman J., Dolan M.C. Protection against Lyme disease spirochete transmission provided by prompt removal of nymphal Ixodes scapularis (Acari: Ixodidae). J Med Entomol 2002, 39(3):509-512.
54. Sood S.K. Prevention of Lyme borreliosis. Lyme borreliosis in Europe and North America: epidemiology and clinical practice 2011, 225-244. John Wiley & Sons, Inc, Hoboken (NJ). S.K. Sood (Ed.).
55. Duscher G.G., Peschke R., Tichy A. Mechanical tools for the removal of Ixodes ricinus female ticks-differences of instruments and pulling or twisting?. Parasitol Res 2012, 111(4):1505-1511.
56. Herrington J.E. Risk perceptions regarding ticks and Lyme disease: a national survey. Am J Prev Med 2004, 26(2):135-140.
57. Gould L.H., Nelson R.S., Griffith K.S., et al. Knowledge, attitudes, and behaviors regarding Lyme disease prevention among Connecticut residents, 1999-2004. Vector Borne Zoonotic Dis 2008, 8(6):769-776.
58. Schofield S., Crane F., Tepper M. Good interventions that few use: uptake of insect bite precautions in a group of Canadian forces personnel deployed to Kabul, Afghanistan. Mil Med 2012, 177(2):209-215.
59. Bayles B.R., Evans G., Allan B.F. Knowledge and prevention of tick-borne diseases vary across an urban-to-rural human land-use gradient. Ticks Tick Borne Dis 2013, 4(4):352-358.
60. Hook S.A., Nelson C.A., Mead P.S. U.S. public's experience with ticks and tick-borne diseases: results from national HealthStyles surveys. Ticks Tick Borne Dis 2015, 6(4):483-488.
61. Stafford K.C. Tick management handbook: an integrated guide for homeowners, pest control operators, and public health officials for the prevention of tick-associated disease. Bulletin 1010 2007, 78. Agricultural Experiment Station, New Haven (CT).
62. Schulze T.L., Jordan R.A., Hung R.W., et al. Efficacy of granular deltamethrin against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidade) nymphs. J Med Entomol 2001, 38(2):344-346.
63. Schulze T.L., Jordan R.A., Krivenko A.J. Effects of barrier application of granular deltamethrin on subadult Ixodes scapularis (Acari: Ixodidae) and nontarget forest floor arthropods. J Econ Entomol 2005, 98(3):976-981.
64. Dolan M.C., Jordan R.A., Schulze T.L., et al. Ability of two natural products, nootkatone and carvacrol, to suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme disease endemic area of New Jersey. J Econ Entomol 2009, 102(6):2316-2324.
65. Rand P.W., Lacombe E.H., Elias S.P., et al. Trial of a minimal-risk botanical compound to control the vector tick of Lyme disease. J Med Entomol 2010, 47(4):695-698.
66. Bharadwaj A., Stafford K.C., Behle R.W. Efficacy and environmental persistence of nootkatone for the control of the blacklegged tick (Acari: Ixodidae) in residential landscapes. J Med Entomol 2012, 49(5):1035-1044.
67. Kiss T., Cadar D., Spinu M. Tick prevention at a crossroad: new and renewed solutions. Vet Parasitol 2012, 187(3-4):357-366.
68. Brei B., Brownstein J.S., George J.E., et al. Evaluation of the United States Department of Agriculture Northeast Area-wide Tick Control Project by meta-analysis. Vector Borne Zoonotic Dis 2009, 9(4):423-430.
69. Dolan M.C., Maupin G.O., Schneider B.S., et al. Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J Med Entomol 2004, 41(6):1043-1054.
70. Grear J.S., Koethe R., Hoskins B., et al. The effectiveness of permethrin-treated deer stations for control of the Lyme disease vector Ixodes scapularis on Cape Cod and the islands: a five-year experiment. Parasit Vectors 2014, 7:292.
71. Stafford K.C., Kitron U. Environmental management for Lyme borreliosis control. Lyme borreliosis biology, epidemiology and control 2002, 301-347. CABI, Wallingford (CT). O. Kahl, R.S. Lane, G. Stanek (Eds.).
72. Sorensen A., van Beest F.M., Brook R.K. Impacts of wildlife baiting and supplemental feeding on infectious disease transmission risk: a synthesis of knowledge. Prev Vet Med 2014, 113(4):356-363.
73. Piesman J. Strategies for reducing the risk of Lyme borreliosis in North America. Int J Med Microbiol 2006, 296(Suppl 40):17-22.
74. Wilson M.L., Ducey A.M., Litwin T.S., et al. Microgeographic distribution of immature Ixodes dammini ticks correlated with that of deer. Med Vet Entomol 1990, 4(2):151-159.
75. Rand P.W., Lubelczyk C., Lavigne G.R., et al. Deer density and the abundance of Ixodes scapularis (Acari: Ixodidae). J Med Entomol 2003, 40(2):179-184.
76. Jordan R.A., Schulze T.L., Jahn M.B. Effects of reduced deer density on the abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme disease incidence in a northern New Jersey endemic area. J Med Entomol 2007, 44(5):752-757.
77. Kilpatrick H.J., LaBonte A.M., Stafford K.C. The relationship between deer density, tick abundance, and human cases of Lyme disease in a residential community. J Med Entomol 2014, 51(4):777-784.
78. Rand P.W., Lubelczyk C., Holman M.S., et al. Abundance of Ixodes scapularis (Acari: Ixodidae) after the complete removal of deer from an isolated offshore island, endemic for Lyme disease. J Med Entomol 2004, 41(4):779-784.
79. McShea W.J. Ecology and management of white-tailed deer in a changing world. Ann N Y Acad Sci 2012, 1249:45-56.
80. In Defense of Animals. Anti-Hunting. Available at:. Accessed April 27, 2015. http://www.idausa.org/campaigns/wild-free2/habitats-campaign/anti-hunting/.
81. Stafford K.C. Reduced abundance of Ixodes scapularis (Acari: Ixodidae) with exclusion of deer by electric fencing. J Med Entomol 1993, 30(6):986-996.
82. Daniels T.J., Fish D. Effect of deer exclusion on the abundance of immature Ixodes scapularis (Acari: Ixodidae) parasitizing small and medium-sized mammals. J Med Entomol 1995, 32(1):5-11.
83. Del Fabbro S. Fencing and mowing as effective methods for reducing tick abundance on very small, infested plots. Ticks Tick Borne Dis 2015, 6(2):167-172.
84. Ley C., Olshen E.M., Reingold A.L. Case-control study of risk factors for incident Lyme disease in California. Am J Epidemiol 1995, 142(9 Suppl):S39-S47.
85. Goossens H.A., van den Bogaard A.E., Nohlmans M.K. Dogs as sentinels for human Lyme borreliosis in The Netherlands. J Clin Microbiol 2001, 39(3):844-848.
86. Berrada Z.L., Telford S.R. Burden of tick-borne infections on American companion animals. Top Companion Anim Med 2009, 24(4):175-181.
87. Rabinowitz P.M., Gordon Z., Odofin L. Pet-related infections. Am Fam Physician 2007, 76(9):1314-1322.
88. Richer L.M., Brisson D., Melo R., et al. Reservoir targeted vaccine against Borrelia burgdorferi: a new strategy to prevent Lyme disease transmission. J Infect Dis 2014, 209(12):1972-1980.
89. Gomes-Solecki M. Blocking pathogen transmission at the source: reservoir targeted OspA-based vaccines against Borrelia burgdorferi. Front Cell Infect Microbiol 2014, 4:136.
90. Tsao J.I., Wootton J.T., Bunikis J., et al. An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc Natl Acad Sci U S A 2004, 101(52):18159-18164.
91. Tsao K., Fish D., Galvani A.P. Predicted outcomes of vaccinating wildlife to reduce human risk of Lyme disease. Vector Borne Zoonotic Dis 2012, 12(7):544-551.
92. Berger K.A., Ginsberg H.S., Dugas K.D., et al. Adverse moisture events predict seasonal abundance of Lyme disease vector ticks (Ixodes scapularis). Parasit Vectors 2014, 7:181.
93. Wilson M.L. Reduced abundance of adult Ixodes dammini (Acari: Ixodidae) following destruction of vegetation. J Econ Entomol 1986, 79(3):693-696.
94. Schulze T.L., Jordan R.A., Hung R.W. Suppression of subadult Ixodes scapularis (Acari: Ixodidae) following removal of leaf litter. J Med Entomol 1995, 32(5):730-733.
95. Mather T.N., Duffy D.C., Campbell S.R. An unexpected result from burning vegetation to reduce Lyme disease transmission risks. J Med Entomol 1993, 30(3):642-645.
96. Stafford K.C., Ward J.S., Magnarelli L.A. Impact of controlled burns on the abundance of Ixodes scapularis (Acari: Ixodidae). J Med Entomol 1998, 35(4):510-513.
97. Williams S.C., Ward J.S. Effects of Japanese barberry (Ranunculales: Berberidaceae) removal and resulting microclimatic changes on Ixodes scapularis (Acari: Ixodidae) abundances in Connecticut, USA. Environ Entomol 2010, 39(6):1911-1921.
98. Stafford K.C., Allan S.A. Field applications of entomopathogenic fungi Beauveria bassiana and Metarhizium anisopliae F52 (Hypocreales: Clavicipitaceae) for the control of Ixodes scapularis (Acari: Ixodidae). J Med Entomol 2010, 47(6):1107-1115.
99. Bharadwaj A., Stafford K.C. Evaluation of Metarhizium anisopliae strain F52 (Hypocreales: Clavicipitaceae) for control of Ixodes scapularis (Acari: Ixodidae). J Med Entomol 2010, 47(5):862-867.
100. Fernandes E.K., Bittencourt V.R., Roberts D.W. Perspectives on the potential of entomopathogenic fungi in biological control of ticks. Exp Parasitol 2012, 130(3):300-305.
101. Duffy D.C., Downer R., Brinkley C. The effectiveness of Helmeted Guneafowl in the control of the deer tick, the vector of Lyme disease. Wilson Bulletin 1992, 104:342.
102. Hinckley A, Meek J, Ray J, et al. Efficacy of a single peridomestic application of acaricide to prevent Lyme and other tick-borne diseases. Presented at: 13th International Conference on Lyme Borreliosis and Other Tick-Borne Diseases. Boston (MA), August 18-21, 2013.
103. Nigrovic L.E., Thompson K.M. The Lyme vaccine: a cautionary tale. Epidemiol Infect 2007, 135(1):1-8.
104. Marconi R.T., Earnhart C.G. Lyme disease vaccines. Borrelia: molecular biology, host interaction and pathogenesis 2010, 467-486. Caister Academic Press, Norfolk (United Kingdom). D.S. Samuels, J.D. Radolf (Eds.).
105. Costello C.M., Steere A.C., Pinkerton R.E., et al. A prospective study of tick bites in an endemic area for Lyme disease. J Infect Dis 1989, 159(1):136-139.
106. Shapiro E.D., Gerber M.A., Holabird N.B., et al. A controlled trial of antimicrobial prophylaxis for Lyme disease after deer-tick bites. N Engl J Med 1992, 327(25):1769-1773.
107. Agre F., Schwartz R. The value of early treatment of deer tick bites for the prevention of Lyme disease. Am J Dis Child 1993, 147(9):945-947.
108. Warshafsky S., Lee D.H., Francois L.K., et al. Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis. J Antimicrob Chemother 2010, 65(6):1137-1144.
109. Wormser G.P., Dattwyler R.J., Shapiro E.D., et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006, 43(9):1089-1134.
110. Institute of Medicine. Clinical Practice Guidelines We Can Trust. Washington, DC: The National Academies Press; 2011.
111. Perea A.E., Hinckley A.F., Mead P.S. Tick bite prophylaxis: results from a 2012 survey of healthcare providers. Zoonoses Public Health 2015, 62(5):388-392.
112. Brett M.E., Hinckley A.F., Zielinski-Gutierrez E.C., et al. U.S. healthcare providers' experience with Lyme and other tick-borne diseases. Ticks Tick Borne Dis 2014, 5(4):404-408.
113. Bissinger B.W., Roe R.M. Tick repellents: past, present, and future. Pestic Biochem Physiol 2010, 96(2):63-79.
114. Katz T.M., Miller J.H., Hebert A.A. Insect repellents: historical perspectives and new developments. J Am Acad Dermatol 2008, 58(5):865-871.
115. Shadick N.A., Daltroy L.H., Phillips C.B., et al. Determinants of tick-avoidance behaviors in an endemic area for Lyme disease. Am J Prev Med 1997, 13(4):265-270.