Epidemiology and cost of hospital care for Lyme borreliosis in Germany: Lessons from a health care utilization database analysis

Ticks and Tick-borne Diseases

Volumn 6, Issue 1, 2015, Pages 56-62

  Lohr, B ^a   Muller I ^a   Mai, M ^a   Norris, D E ^b   Schoffski O ^c   Hunfel, K P ^a  

^a GOETHE UNIVERSITY   (Germany)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Costs; Epidemiology; Germany; Health care utilization database; Hospital care; Lyme borreliosis

Indexed keywords

ADOLESCENT; ADULT; AGE; ARTICLE; CLINICAL FEATURE; COST OF ILLNESS; DATA BASE; FEMALE; GERMANY; HEALTH CARE COST; HEALTH CARE UTILIZATION; HEALTH INSURANCE; HOSPITAL ADMISSION; HUMAN; INCIDENCE; LENGTH OF STAY; LYME DISEASE; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOCIAL STATUS; AGED; BORRELIA BURGDORFERI; CHILD; COHORT ANALYSIS; ECONOMICS; HOSPITALIZATION; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD; SEASON; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BORRELIA BURGDORFERI; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GERMANY; HOSPITALIZATION; HUMANS; INCIDENCE; LYME DISEASE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEASONS; YOUNG ADULT;

EID: 84947435926     PISSN: 1877959X     EISSN: 18779603     Source Type: Journal    
DOI: 10.1016/j.ttbdis.2014.09.004     Document Type: Article

References (47)

1. Akobundu, E., Ju, J., Blatt, L., Mullins, C.D., 2006. Cost-of-illness studies. Pharma-coeconomics 24, 869-890.
2. Athreya, B.H., Rose, C.D., 1996. Lyme disease. Curr. Probl. Pediatr. 26, 189-207.
3. Aucott, J., Morrison, C., Munoz, B., Rowe, P.C., Schwarzwalder, A., West, S.K., 2009.Diagnostic challenges of early Lyme disease: lessons from a community caseseries. BMC Infect. Dis. 9, 79, http://dx.doi.org/10.1186/1471-2334-9-79.
4. Bacon, R.M., Kugeler, K.J., Mead, P.S., 2008. Surveillance for Lyme disease - UnitedStates, 1992-2006. MMWR Surveill. Summ. 57, 1-9.
5. Beaujean, D.J.M.A., Bults, M., van Steenbergen, J.E., Voeten, H.A.C.M., 2013. Study onpublic perceptions and protective behaviors regarding Lyme disease among thegeneral public in the Netherlands: implications for prevention programs. BMCPublic Health 13, 225, http://dx.doi.org/10.1186/1471-2458-13-225.
6. Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringér, A., Elmrud, H., Carls-son, M., Runehagen, A., Svanborg, C., Norrby, R., 1995. An epidemiologicstudy of Lyme disease in southern Sweden. N. Engl. J. Med. 333, 1319-1327,http://dx.doi.org/10.1056/NEJM199511163332004.
7. Bingsohn, L., Beckert, A., Zehner, R., Kuch, U., Oehme, R., Kraiczy, P., Amendt, J., 2013.Prevalences of tick-borne encephalitis virus and Borrelia burgdorferi sensu lato inIxodes ricinus populations of the Rhine-Main region, Germany. Ticks Tick BorneDis. 4, 207-213, http://dx.doi.org/10.1016/j.ttbdis.2012.11.012.
8. Christen, H.J., 1996. Lyme neuroborreliosis in children. Ann. Med. 28, 235-240.
9. Christova, I., Komitova, R., 2004. Clinical and epidemiological features of Lyme bor-reliosis in Bulgaria. Wien. Klin. Wochenschr. 116, 42-46.
10. Dehnert, M., Fingerle, V., Klier, C., Talaska, T., Schlaud, M., Krause, G., Wilking, H., Poggensee, G., 2012. Seropositivity of Lyme borreliosis and associated risk fac-tors: a population-based study in Children and Adolescents in Germany (KiGGS).PLOS ONE 7, e41321, http://dx.doi.org/10.1371/journal.pone.0041321.
11. Dhôte, R., Basse-Guerineau, A.L., Beaumesnil, V., Christoforov, B., Assous, M.V., 2000.Full spectrum of clinical, serological, and epidemiological features of compli-cated forms of Lyme borreliosis in the Paris, France, area. Eur. J. Clin. Microbiol. Infect. Dis. 19, 809-815.
12. Dobson, A.D., Taylor, J.L., Randolph, S.E., 2011. Tick (Ixodes ricinus) abundance andseasonality at recreational sites in the UK: hazards in relation to fine-scale habi-tat types revealed by complementary sampling methods. Ticks Tick Borne Dis.2, 67-74, http://dx.doi.org/10.1016/j.ttbdis.2011.03.002.
13. Esposito, S., Bosis, S., Sabatini, C., Tagliaferri, L., Principi, N., 2013. Borrelia burgdor-feri infection and Lyme disease in children. Int. J. Infect. Dis. 17, e153,http://dx.doi.org/10.1016/j.ijid.2012.09.014.
14. Farhan, J., Al-Jummaa, S., Alrajhi, A.A., Al-Rajhi, A., Al-Rayes, H., Al-Nasser, A., 2005.Documentation and coding of medical records in a tertiary care center: a pilotstudy. Ann. Saudi Med. 25, 46-49.
15. Fingerle, V., Schulte-Spechtel, U.C., Ruzic-Sabljic, E., Leonhard, S., Hofmann, H., Weber, K., Pfister, K., Strle, F., Wilske, B., 2008. Epidemiological aspects andmolecular characterization of Borrelia burgdorferi s.l. from southern Germanywith special respect to the new species Borrelia spielmanii sp. nov. Int. J. Med. Microbiol. 289, 279-290, http://dx.doi.org/10.1016/j.ijmm.2007.05.002.
16. Fülöp, B., Poggensee, G., 2008. Epidemiological situation of Lyme borreliosis inGermany: surveillance data from six Eastern German States, 2002 to 2006. Para-sitol. Res. 103, 117-120, http://dx.doi.org/10.1007/s00436-008-1060-y. GBE, 2014. Available from: https://www.gbe-bund.de/gbe10/trecherche.prc themrech?tk=8500&tk2=14300&puid=gast&paid=18173984&p sprache=D&cntut=1&ut=14300 (cited 28.03.14).
17. Graf von der Schulenburg, J.-M., Greiner, W., Jost, F., Klusen, N., Kubin, M., Leidl, R., Mittendorf, T., Rebscher, H., Schöffski, O., Vauth, C., Volmer, T., Wahler, S., Wasem, J., Weber, C., 2007. Deutsche Empfehlungen zur gesundheit-sökonomischen Evaluation - dritte und aktualisierte Fassung des HannoveranerKonsens. Gesundh ökon Qual Manag. 12, 285-290, http://dx.doi.org/10.1055/s-2007-963505.
18. Grobe, T.G., 2008. Arbeiten mit Daten der Gmünder Ersatzkasse. Ein exemplarischerüberblick (Work based on data of the Gmünder Ersatzkasse. An exemplaryoverview). Bundesgesundheitsblatt 51, 1106-1111, http://dx.doi.org/10.1007/s00103-008-0645-z.
19. Haagsma, J.A., Geenen, P.L., Ethelberg, S., Fetsch, A., Hansdotter, F., Jansen, A., Korsgaard, H., O'Brien, S.J., Scavia, G., SpitznagelL, H., Stefanoff, P., Tam, C.C., Havelaar, A.H., 2013. Community incidence of pathogen-specific gastroenteritis:reconstructing the surveillance pyramid for seven pathogens in seven EuropeanUnion member states. Epidemiol. Infect. 141, 1625-1639, http://dx.doi.org/10.1017/S0950268812002166.
20. Havelaar, A.H., Ivarsson, S., Löfdahl, M., Nauta, M.J., 2013. Estimating thetrue incidence of campylobacteriosis and salmonellosis in the EuropeanUnion, 2009. Epidemiol. Infect. 141, 293-302, http://dx.doi.org/10.1017/S0950268812000568.
21. Henningsson, A.J., Malmvall, B.-E., Ernerudh, J., Matussek, A., Forsberg, P., 2010. Neu-roborreliosis - an epidemiological, clinical and healthcare cost study from anendemic area in the south-east of Sweden. Clin. Microbiol. Infect. 16, 1245-1251,http://dx.doi.org/10.1111/j. 1469-0691.2009.03059.x.
22. Hoffmann, W., Bobrowski, C., Fendrich, K., 2008. Sekundärdatenanalyse in derVersorgungsepidemiologie. Potenzial und Limitationen (Secondary dataanalysis in the field of epidemiology of health care. Potential and lim-itations). Bundesgesundheitsblatt 51, 1193-1201, http://dx.doi.org/10.1007/s00103-008-0654-y.
23. Huppertz, H.I., Böhme, M., Standaert, S.M., Karch, H., Plotkin, S.A., 1999. Incidenceof Lyme borreliosis in the Würzburg region of Germany. Eur. J. Clin. Microbiol. Infect. Dis. 18, 697-703.
24. Jetté, N., Quan, H., Hemmelgarn, B., Drosler, S., Maass, C., Moskal, L., Paoin, W., Sundararajan, V., Gao, S., Jakob, R., Üstün, B., Ghali, W.A., 2010. The development, evolution, and modifications of ICD-10. Med. Care 48, 1105-1110, http://dx.doi.org/10.1097/MLR.0b013e3181ef9d3e.
25. Joss, A.W.L., Davidson, M.M., Ho-Yen, D.O., Ludbrook, A., 2003. Lyme disease - whatis the cost for Scotland? Public Health 117, 264-273.
26. Kuehn, B.M., 2013. CDC estimates 300 000 US cases of Lyme disease annually. JAMA310, 1110, http://dx.doi.org/10.1001/jama.2013.278331.
27. Lindgren, E., Jaenson, T.G.T., 2006. Lyme Borreliosis in Europe: Influences of Climateand Climate Change, Epidemiology, Ecology and Adaptation Measures. WorldHealth Organization, Copenhagen (report no.: EUR/04/5046250).
28. Lipsker, D., Hansmann, Y., Limbach, F., Clerc, C., Tranchant, C., Grunenberger, F., Caro-Sampara, F., Attali, P., Frey, M., Kubina, M., Piémont, Y., Sibilia, J., Jaulhac, B.,2001. Disease expression of Lyme borreliosis in northeastern France. Eur. J. Clin. Microbiol. Infect. Dis. 20, 225-230.
29. Maes, E., Lecomte, P., Ray, N., 1998. A cost-of-illness study of Lyme disease in theUnited States. Clin. Ther. 20, 993-1008.
30. Müller, I., Freitag, M.H., Poggensee, G., Scharnetzky, E., Straube, E., Schoerner, C., Hlobil, H., Hagedorn, H.-J., Stanek, G., Schubert-Unkmeir, A., Norris, D.E., Gensichen, J., Hunfeld, K.-P., 2012. Evaluating frequency, diagnostic quality, andcost of Lyme borreliosis testing in Germany: a retrospective model analysis. Clin. Dev. Immunol., 595427, http://dx.doi.org/10.1155/2012/595427.
31. O'Connell, S., Granström, M., Gray, J.S., Stanek, G., 1998. Epidemiology of EuropeanLyme borreliosis. Zentralbl. Bakteriol. 287, 229-240.
32. Peña, C.A., Strickland, G.T., 1999. Incidence rates of Lyme disease in Maryland: 1993through 1996. Md. Med. J. 48, 68-73.
33. Reinhold, T., Thierfelder, K., Müller-Riemenschneider, F., Willich, S., 2009.Gesundheitsökonomische Auswirkungen der DRG-Einführung in Deutschland- eine systematische übersicht (Health economic effects after DRG-implementation - a systematic overview). Gesundheitswesen 71, 306-312,http://dx.doi.org/10.1055/s-0028-1119399.
34. RKI, 2009. Krankheiten, für die gemäß LVO eine erweiterte Meldepflicht zusätzlichzum IfSG besteht (Stand 2009). Epidemiol. Bull. 5, 33-49.
35. Schlomer, B.J., Copp, H.L., 2014. Secondary data analysis of large datasets in urology: successes and errors to avoid. J. Urol. 191, 587-596,http://dx.doi.org/10.1016/j.juro.2013.09.091.
36. Stanek, G., Fingerle, V., Hunfeld, K.-P., Jaulhac, B., Kaiser, R., Krause, A., Kristoferitsch, W., O'Connell, S., Ornstein, K., Strle, F., Gray, J., 2011. Lyme borreliosis: clinicalcase definitions for diagnosis and management in Europe. Clin. Microbiol. Infect.17, 69-79, http://dx.doi.org/10.1111/j. 1469-0691.2010.03175.x.
37. Stanek, G., Wormser, G.P., Gray, J., Strle, F., 2012. Lyme borreliosis. Lancet 379,461-473, http://dx.doi.org/10.1016/S0140-6736(11)60103-7.
38. Statistisches Bundesamt, 2014. https://www.destatis.de/DE/Publikationen/Thematisch/Gesundheit/Krankenhaeuser/GrunddatenKrankenhaeuser.html(cited 18.03.14).
39. Steere, A.C., Taylor, E., McHugh, G.L., Logigian, E.L., 1993. The overdiagnosis of Lymedisease. JAMA 269, 1812-1816.
40. Stock, S.A.K., Redaelli, M., Wendland, G., Civello, D., Lauterbach, K.W., 2006.Diabetes-prevalence and cost of illness in Germany: a study evaluating datafrom the statutory health insurance in Germany. Diabet. Med. 23, 299-305,http://dx.doi.org/10.1111/j. 1464-5491.2005.01779.x.
41. Strle, F., Wormser, G.P., Mead, P., Dhaduvai, K., Longo, M.V., Adenikinju, O., Soman, S., Tefera, Y., Maraspin, V., Lotrĭ-Furlan, S., Ogrinc, K., Cimperman, J., Rᅭzić-Sabljić, E., Stupica, D., 2013. Gender disparity between cutaneousand non-cutaneous manifestations of Lyme borreliosis. PLOS ONE 8, e64110,http://dx.doi.org/10.1371/journal.pone.0064110.
42. Tugwell, P., Dennis, D.T., Weinstein, A., Wells, G., Shea, B., Nichol, G., Hayward, R., Lightfoot, R., Baker, P., Steere, A.C., 1997. Laboratory evaluation in the diagnosisof Lyme disease. Ann. Intern. Med. 127, 1109-1123.
43. Vandenesch, A., Turbelin, C., Couturier, E., Arena, C., Jaulhac, B., Ferquel, E., Choumet, V., Saugeon, C., Coffinieres, E., Blanchon, T., Vaillant, V., Hanslik, T., 2014. Inci-dence and hospitalisation rates of Lyme borreliosis, France, 2004 to 2012.Eurosurveillance, 19.
44. van Roijen, L., Koopmanschap, M.A., Rutten, F.F., van der Maas, P.J., 1995. Indirectcosts of disease; an international comparison. Health Policy 33, 15-29.
45. Wilking, H., Stark, K., 2014. Trends in surveillance data of human Lyme borreliosisfrom six federal states in eastern Germany, 2009-2012. Ticks Tick Borne Dis. 5,219-224, http://dx.doi.org/10.1016/j.ttbdis.2013.10.010.
46. Wormser, G.P., Dattwyler, R.J., Shapiro, E.D., Halperin, J.J., Steere, A.C., Klempner, M.S., Krause, P.J., Bakken, J.S., Strle, F., Stanek, G., Bockenstedt, L., Fish, D., Dumler, J.S., Nadelman, R.B., 2006. The clinical assessment, treatment, and pre-vention of lyme disease, human granulocytic anaplasmosis, and babesiosis:clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 43, 1089-1134, http://dx.doi.org/10.1086/508667.
47. Zhang, X., Meltzer, M.I., Peña, C.A., Hopkins, A.B., Wroth, L., Fix, A.D.,2006. Economic impact of Lyme disease. Emerg. Infect. Dis. 12, 653-660,http://dx.doi.org/10.3201/eid1204.050602.