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Volumn 24, Issue 23, 2015, Pages 2808-2821

IL-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma Through Efficient Delivery of IL-21, Which Redirects the Immune System to Target the Tumor

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; RECOMBINANT INTERLEUKIN 21; INTERLEUKIN 21; INTERLEUKIN DERIVATIVE;

EID: 84947421679     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2015.0103     Document Type: Article
Times cited : (27)

References (57)
  • 2
  • 6
  • 7
    • 33746479282 scopus 로고    scopus 로고
    • Interleukin-21 gene transfection into mouse bladder cancer cells results in tumor rejection through the cytotoxic T lymphocyte response
    • Furukawa J, I Hara, H Nagai, A Yao, S Oniki and M Fujisawa. (2006). Interleukin-21 gene transfection into mouse bladder cancer cells results in tumor rejection through the cytotoxic T lymphocyte response. J Urol 176:1198-1203.
    • (2006) J Urol , vol.176 , pp. 1198-1203
    • Furukawa, J.1    Hara, I.2    Nagai, H.3    Yao, A.4    Oniki, S.5    Fujisawa, M.6
  • 8
    • 0037347311 scopus 로고    scopus 로고
    • Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
    • Ugai S, O Shimozato, K Kawamura, YQ Wang, T Yamaguchi, H Saisho, S Sakiyama and M Tagawa. (2003). Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther 10:187-192.
    • (2003) Cancer Gene Ther , vol.10 , pp. 187-192
    • Ugai, S.1    Shimozato, O.2    Kawamura, K.3    Wang, Y.Q.4    Yamaguchi, T.5    Saisho, H.6    Sakiyama, S.7    Tagawa, M.8
  • 9
    • 33746088835 scopus 로고    scopus 로고
    • Combined IL-21 and low-dose IL-2 therapy induces anti-Tumor immunity and long-Term curative effects in a murine melanoma tumor model
    • He H, P Wisner, G Yang, HM Hu, D Haley, W Miller, A OHara, WG Alvord, CH Clegg, et al. (2006). Combined IL-21 and low-dose IL-2 therapy induces anti-Tumor immunity and long-Term curative effects in a murine melanoma tumor model. J Transl Med 4:24.
    • (2006) J Transl Med , vol.4 , pp. 24
    • He, H.1    Wisner, P.2    Yang, G.3    Hu, H.M.4    Haley, D.5    Miller, W.6    O'Hara, A.7    Alvord, W.G.8    Clegg, C.H.9
  • 10
    • 63449095686 scopus 로고    scopus 로고
    • Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: A phase IIa trial
    • Davis ID, B Brady, RF Kefford, M Millward, J Cebon, BK Skrumsager, U Mouritzen, LT Hansen, K Skak, et al. (2009). Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial. Clin Cancer Res 15:2123-2129.
    • (2009) Clin Cancer Res , vol.15 , pp. 2123-2129
    • Davis, I.D.1    Brady, B.2    Kefford, R.F.3    Millward, M.4    Cebon, J.5    Skrumsager, B.K.6    Mouritzen, U.7    Hansen, L.T.8    Skak, K.9
  • 13
    • 78049485488 scopus 로고    scopus 로고
    • Safety and clinical effect of subcutaneous human interleukin-21 in patients with metastatic melanoma or renal cell carcinoma: A phase i trial
    • Schmidt H, J Brown, U Mouritzen, P Selby, K Fode, IM Svane, GP Cook, DH Mollerup and PF Geertsen. (2010). Safety and clinical effect of subcutaneous human interleukin-21 in patients with metastatic melanoma or renal cell carcinoma: a phase I trial. Clin Cancer Res 16:5312-5319.
    • (2011) Clin Cancer Res , vol.16 , pp. 5312-5319
    • Schmidt, H.1    Brown, J.2    Mouritzen, U.3    Selby, P.4    Fode, K.5    Svane, I.M.6    Cook, G.P.7    Mollerup, D.H.8    Geertsen, P.F.9
  • 16
    • 84867524002 scopus 로고    scopus 로고
    • A phase i dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disorders
    • Timmerman JM, JC Byrd, DJ Andorsky, RE Yamada, J Kramer, N Muthusamy, N Hunder and JM Pagel. (2012). A phase I dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disorders. Clin Cancer Res 18:5752-5760.
    • (2012) Clin Cancer Res , vol.18 , pp. 5752-5760
    • Timmerman, J.M.1    Byrd, J.C.2    Andorsky, D.J.3    Yamada, R.E.4    Kramer, J.5    Muthusamy, N.6    Hunder, N.7    Pagel, J.M.8
  • 17
    • 77951134921 scopus 로고    scopus 로고
    • Interleukin-21: Updated review of Phase i and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkins lymphoma
    • Hashmi MH and PJ Van Veldhuizen. (2010). Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkins lymphoma. Expert Opin Biol Ther 10:807-817.
    • (2011) Expert Opin Biol Ther , vol.10 , pp. 807-817
    • Hashmi, M.H.1    Van Veldhuizen, P.J.2
  • 18
    • 84880396453 scopus 로고    scopus 로고
    • Clinical applications of mesenchymal stem cells
    • Kim N and SG Cho. (2013). Clinical applications of mesenchymal stem cells. Korean J Intern Med 28:387-402.
    • (2013) Korean J Intern Med , vol.28 , pp. 387-402
    • Kim, N.1    Cho, S.G.2
  • 19
    • 43049139914 scopus 로고    scopus 로고
    • Inflammation and tumor microenvironments: Defining the migratory itinerary of mesenchymal stem cells
    • Spaeth E, A Klopp, J Dembinski, M Andreeff and F Marini. (2008). Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 15:730-738.
    • (2008) Gene Ther , vol.15 , pp. 730-738
    • Spaeth, E.1    Klopp, A.2    Dembinski, J.3    Andreeff, M.4    Marini, F.5
  • 21
    • 77649185403 scopus 로고    scopus 로고
    • Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma
    • Gao P, Q Ding, Z Wu, H Jiang and Z Fang. (2010). Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma. Cancer Lett 290:157-166.
    • (2011) Cancer Lett , vol.290 , pp. 157-166
    • Gao, P.1    Ding, Q.2    Wu, Z.3    Jiang, H.4    Fang, Z.5
  • 22
    • 73349125063 scopus 로고    scopus 로고
    • Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgammatransduced tumor cell immunotherapy of experimental glioma
    • Gunnarsson S, D Bexell, A Svensson, P Siesjo, A Darabi and J Bengzon. (2010). Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgammatransduced tumor cell immunotherapy of experimental glioma. J Neuroimmunol 218:140-144.
    • (2011) J Neuroimmunol , vol.218 , pp. 140-144
    • Gunnarsson, S.1    Bexell, D.2    Svensson, A.3    Siesjo, P.4    Darabi, A.5    Bengzon, J.6
  • 23
    • 55049094527 scopus 로고    scopus 로고
    • Therapeutic potential of mesenchymal stem cells producing interferon-Alpha in a mouse melanoma lung metastasis model
    • Ren C, S Kumar, D Chanda, J Chen, JD Mountz and S Ponnazhagan. (2008). Therapeutic potential of mesenchymal stem cells producing interferon-Alpha in a mouse melanoma lung metastasis model. Stem Cells 26:2332-2338.
    • (2008) Stem Cells , vol.26 , pp. 2332-2338
    • Ren, C.1    Kumar, S.2    Chanda, D.3    Chen, J.4    Mountz, J.D.5    Ponnazhagan, S.6
  • 24
    • 79955943420 scopus 로고    scopus 로고
    • The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity
    • Seo SH, KS Kim, SH Park, YS Suh, SJ Kim, SS Jeun and YC Sung. (2011). The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity. Gene Ther 18:488-495.
    • (2011) Gene Ther , vol.18 , pp. 488-495
    • Seo, S.H.1    Kim, K.S.2    Park, S.H.3    Suh, Y.S.4    Kim, S.J.5    Jeun, S.S.6    Sung, Y.C.7
  • 25
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    • Studeny M, FC Marini, RE Champlin, C Zompetta, IJ Fidler and M Andreeff. (2002). Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 62:3603-3608.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3    Zompetta, C.4    Fidler, I.J.5    Andreeff, M.6
  • 26
    • 66249083525 scopus 로고    scopus 로고
    • Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer
    • Loebinger MR, A Eddaoudi, D Davies and SM Janes. (2009). Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res 69:4134-4142.
    • (2009) Cancer Res , vol.69 , pp. 4134-4142
    • Loebinger, M.R.1    Eddaoudi, A.2    Davies, D.3    Janes, S.M.4
  • 27
    • 79952899402 scopus 로고    scopus 로고
    • TRAIL-Transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo
    • Mueller LP, J Luetzkendorf, M Widder, K Nerger, H Caysa and T Mueller. (2011). TRAIL-Transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo. Cancer Gene Ther 18:229-239.
    • (2011) Cancer Gene Ther , vol.18 , pp. 229-239
    • Mueller, L.P.1    Luetzkendorf, J.2    Widder, M.3    Nerger, K.4    Caysa, H.5    Mueller, T.6
  • 29
    • 61449210913 scopus 로고    scopus 로고
    • A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow
    • Soleimani M and S Nadri. (2009). A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc 4:102-106.
    • (2009) Nat Protoc , vol.4 , pp. 102-106
    • Soleimani, M.1    Nadri, S.2
  • 30
    • 84881104041 scopus 로고    scopus 로고
    • The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and CD4(+)25(+)Foxp3+ regulatory T cells on skin allograft rejection
    • Lee JH, EJ Jeon, N Kim, YS Nam, KI Im, JY Lim, EJ Kim, ML Cho, KT Han and SG Cho. (2013). The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and CD4(+)25(+)Foxp3+ regulatory T cells on skin allograft rejection. PLoS One 8:e70968.
    • (2013) PLoS One , vol.8 , pp. e70968
    • Lee, J.H.1    Jeon, E.J.2    Kim, N.3    Nam, Y.S.4    Im, K.I.5    Lim, J.Y.6    Kim, E.J.7    Cho, M.L.8    Han, K.T.9    Cho, S.G.10
  • 31
  • 32
    • 33646410652 scopus 로고    scopus 로고
    • Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
    • de Totero D, R Meazza, S Zupo, G Cutrona, S Matis, M Colombo, E Balleari, I Pierri, M Fabbi, et al. (2006). Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood 107:3708-3715.
    • (2006) Blood , vol.107 , pp. 3708-3715
    • De Totero, D.1    Meazza, R.2    Zupo, S.3    Cutrona, G.4    Matis, S.5    Colombo, M.6    Balleari, E.7    Pierri, I.8    Fabbi, M.9
  • 35
    • 47149117792 scopus 로고    scopus 로고
    • IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro
    • Gowda A, J Roda, SR Hussain, A Ramanunni, T Joshi, S Schmidt, X Zhang, A Lehman, D Jarjoura, et al. (2008). IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 111:4723-4730.
    • (2008) Blood , vol.111 , pp. 4723-4730
    • Gowda, A.1    Roda, J.2    Hussain, S.R.3    Ramanunni, A.4    Joshi, T.5    Schmidt, S.6    Zhang, X.7    Lehman, A.8    Jarjoura, D.9
  • 36
    • 77449155831 scopus 로고    scopus 로고
    • Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas
    • Sarosiek KA, R Malumbres, H Nechushtan, AJ Gentles, E Avisar and IS Lossos. (2010). Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Blood 115:570-580.
    • (2011) Blood , vol.115 , pp. 570-580
    • Sarosiek, K.A.1    Malumbres, R.2    Nechushtan, H.3    Gentles, A.J.4    Avisar, E.5    Lossos, I.S.6
  • 38
    • 12744261250 scopus 로고    scopus 로고
    • Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells
    • Ueda M, K Imada, A Imura, H Koga, M Hishizawa and T Uchiyama. (2005). Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells. Br J Haematol 128:169-176.
    • (2005) Br J Haematol , vol.128 , pp. 169-176
    • Ueda, M.1    Imada, K.2    Imura, A.3    Koga, H.4    Hishizawa, M.5    Uchiyama, T.6
  • 40
    • 68449086508 scopus 로고    scopus 로고
    • IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma
    • Dien Bard J, P Gelebart, M Anand, Z Zak, SA Hegazy, HM Amin and R Lai. (2009). IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma. Am J Pathol 175:825-834.
    • (2009) Am J Pathol , vol.175 , pp. 825-834
    • Dien Bard, J.1    Gelebart, P.2    Anand, M.3    Zak, Z.4    Hegazy, S.A.5    Amin, H.M.6    Lai, R.7
  • 41
    • 51849086413 scopus 로고    scopus 로고
    • Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: Comparison with human
    • Chamberlain G, K Wright, A Rot, B Ashton and J Middleton. (2008). Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. PLoS One 3:e2934.
    • (2008) PLoS One , vol.3 , pp. e2934
    • Chamberlain, G.1    Wright, K.2    Rot, A.3    Ashton, B.4    Middleton, J.5
  • 42
    • 0037438371 scopus 로고    scopus 로고
    • Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging
    • Edinger M, YA Cao, MR Verneris, MH Bachmann, CH Contag and RS Negrin. (2003). Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood 101:640-648.
    • (2003) Blood , vol.101 , pp. 640-648
    • Edinger, M.1    Cao, Y.A.2    Verneris, M.R.3    Bachmann, M.H.4    Contag, C.H.5    Negrin, R.S.6
  • 43
    • 27744541175 scopus 로고    scopus 로고
    • Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: Role of NKp30 and NKG2D receptors
    • Poggi A, C Prevosto, AM Massaro, S Negrini, S Urbani, I Pierri, R Saccardi, M Gobbi and MR Zocchi. (2005). Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. J Immunol 175:6352-6360.
    • (2005) J Immunol , vol.175 , pp. 6352-6360
    • Poggi, A.1    Prevosto, C.2    Massaro, A.M.3    Negrini, S.4    Urbani, S.5    Pierri, I.6    Saccardi, R.7    Gobbi, M.8    Zocchi, M.R.9
  • 44
    • 32644438233 scopus 로고    scopus 로고
    • Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
    • Spaggiari GM, A Capobianco, S Becchetti, MC Mingari and L Moretta. (2006). Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 107:1484-1490.
    • (2006) Blood , vol.107 , pp. 1484-1490
    • Spaggiari, G.M.1    Capobianco, A.2    Becchetti, S.3    Mingari, M.C.4    Moretta, L.5
  • 46
    • 38049120319 scopus 로고    scopus 로고
    • IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
    • Li Y and C Yee. (2008). IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 111:229-235.
    • (2008) Blood , vol.111 , pp. 229-235
    • Li, Y.1    Yee, C.2
  • 47
    • 84900032004 scopus 로고    scopus 로고
    • Tumor-Associated antigen/IL-21-Transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma
    • Aravindaram K, PH Wang, SY Yin and NS Yang. (2014). Tumor-Associated antigen/IL-21-Transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma. Gene Ther 21:457-467.
    • (2014) Gene Ther , vol.21 , pp. 457-467
    • Aravindaram, K.1    Wang, P.H.2    Yin, S.Y.3    Yang, N.S.4
  • 48
    • 84883898505 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: Experiments and practice
    • Kim N, KI Im, JY Lim, EJ Jeon, YS Nam, EJ Kim and SG Cho. (2013). Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: experiments and practice. Ann Hematol 92:1295-1308.
    • (2013) Ann Hematol , vol.92 , pp. 1295-1308
    • Kim, N.1    Im, K.I.2    Lim, J.Y.3    Jeon, E.J.4    Nam, Y.S.5    Kim, E.J.6    Cho, S.G.7
  • 49
    • 77954728855 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect breast cancer cells through regulatory T cells: Role of mesenchymal stem cell-derived TGF-beta
    • Patel SA, JR Meyer, SJ Greco, KE Corcoran, M Bryan and P Rameshwar. (2010). Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta. J Immunol 184:5885-5894.
    • (2011) J Immunol , vol.184 , pp. 5885-5894
    • Patel, S.A.1    Meyer, J.R.2    Greco, S.J.3    Corcoran, K.E.4    Bryan, M.5    Rameshwar, P.6
  • 50
    • 0037728761 scopus 로고    scopus 로고
    • Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo
    • Al-Khaldi A, N Eliopoulos, D Martineau, L Lejeune, K Lachapelle and J Galipeau. (2003). Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo. Gene Ther 10:621-629.
    • (2003) Gene Ther , vol.10 , pp. 621-629
    • Al-Khaldi, A.1    Eliopoulos, N.2    Martineau, D.3    Lejeune, L.4    Lachapelle, K.5    Galipeau, J.6
  • 51
    • 21244490450 scopus 로고    scopus 로고
    • Correlation between melanoma angiogenesis and the mesenchymal stem cells and endothelial progenitor cells derived from bone marrow
    • Sun B, S Zhang, C Ni, D Zhang, Y Liu, W Zhang, X Zhao, C Zhao and M Shi. (2005). Correlation between melanoma angiogenesis and the mesenchymal stem cells and endothelial progenitor cells derived from bone marrow. Stem Cells Dev 14:292-298.
    • (2005) Stem Cells Dev , vol.14 , pp. 292-298
    • Sun, B.1    Zhang, S.2    Ni, C.3    Zhang, D.4    Liu, Y.5    Zhang, W.6    Zhao, X.7    Zhao, C.8    Shi, M.9
  • 52
    • 78649320264 scopus 로고    scopus 로고
    • Potential role of mesenchymal stem cells (MSCs) the breast tumour microenvironment: Stimulation of epithelial to mesenchymal transition (EMT)
    • Martin FT, RM Dwyer, J Kelly, S Khan, JM Murphy, C Curran, N Miller, E Hennessy, P Dockery, et al. (2010). Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT). Breast Cancer Res Treat 124:317-326.
    • (2011) Breast Cancer Res Treat , vol.124 , pp. 317-326
    • Martin, F.T.1    Dwyer, R.M.2    Kelly, J.3    Khan, S.4    Murphy, J.M.5    Curran, C.6    Miller, N.7    Hennessy, E.8    Dockery, P.9
  • 54
    • 41849115243 scopus 로고    scopus 로고
    • Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model
    • Qiao L, Z Xu, T Zhao, Z Zhao, M Shi, RC Zhao, L Ye and X Zhang. (2008). Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res 18:500-507.
    • (2008) Cell Res , vol.18 , pp. 500-507
    • Qiao, L.1    Xu, Z.2    Zhao, T.3    Zhao, Z.4    Shi, M.5    Zhao, R.C.6    Ye, L.7    Zhang, X.8
  • 55
    • 84906059145 scopus 로고    scopus 로고
    • Adipose tissuederived mesenchymal stem cells cultured at high density express IFN-beta and suppress the growth of MCF-7 human breast cancer cells
    • Ryu H, JE Oh, KJ Rhee, SK Baik, J Kim, SJ Kang, JH Sohn, E Choi, HC Shin, et al. (2014). Adipose tissuederived mesenchymal stem cells cultured at high density express IFN-beta and suppress the growth of MCF-7 human breast cancer cells. Cancer Lett 352:220-227.
    • (2014) Cancer Lett , vol.352 , pp. 220-227
    • Ryu, H.1    Oh, J.E.2    Rhee, K.J.3    Baik, S.K.4    Kim, J.5    Kang, S.J.6    Sohn, J.H.7    Choi, E.8    Shin, H.C.9
  • 56
    • 33846483151 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth
    • Ramasamy R, EW Lam, I Soeiro, V Tisato, D Bonnet and F Dazzi. (2007). Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 21:304-310.
    • (2007) Leukemia , vol.21 , pp. 304-310
    • Ramasamy, R.1    Lam, E.W.2    Soeiro, I.3    Tisato, V.4    Bonnet, D.5    Dazzi, F.6
  • 57
    • 77955239592 scopus 로고    scopus 로고
    • Human bone marrow mesenchymal stem cells display anticancer activity in SCID mice bearing disseminated non-Hodgkins lymphoma xenografts
    • Secchiero P, S Zorzet, C Tripodo, F Corallini, E Melloni, L Caruso, R Bosco, S Ingrao, B Zavan and G Zauli. (2010). Human bone marrow mesenchymal stem cells display anticancer activity in SCID mice bearing disseminated non-Hodgkins lymphoma xenografts. PLoS One 5:e11140.
    • (2011) PLoS One , vol.5 , pp. e11140
    • Secchiero, P.1    Zorzet, S.2    Tripodo, C.3    Corallini, F.4    Melloni, E.5    Caruso, L.6    Bosco, R.7    Ingrao, S.8    Zavan, B.9    Zauli, G.10


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