Study of the inhibition effect of ethanolic extract of mangosteen pericarp on atherogenesis in hypercholesterolemic rat

Asian Pacific Journal of Tropical Disease

Volumn 5, Issue 10, 2015, Pages 830-834

  Wihastuti, Titin Andri ^a   Widodo, Mochamad Aris ^a   Heriansyah, Teuku ^b   Sari, Novita Apramadha Kartika ^a  

^a BRAWIJAYA UNIVERSITY   (Indonesia)

^b SYIAH KUALA UNIVERSITY   (Indonesia)

Author keywords

Endothelial nitric oxide synthase; Ethanolic extract of mangosteen pericarp; H2O2; Hypercholesterol; Inducible nitric oxide synthase; Lipid profile; Nuclear factor B

Indexed keywords

ANTIOXIDANT; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN; HYDROGEN PEROXIDE; HYPOCHOLESTEROLEMIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN; MANGOSTEEN EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; GARCINIA MANGOSTANA; HYDROGEN PEROXIDE SCAVENGING ASSAY; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; NONHUMAN; PERICARP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

EID: 84947419018     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(15)60940-9     Document Type: Article

References (26)

1. World Health Organization Cardiovascular diseases (CVDs) 2015, World Health Organization, Geneva, [Online], [Accessed on 26th June, 2015]. http://www.who.int/mediacentre/factsheets/fs317/en/.
2. Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC Hypercholesterolemia and microvascular dysfunction: interventional strategies. J Inflamm (Lond) 2010, 7:54.
3. Cave A Selective targeting of NADPH oxidase for cardiovascular protection. Curr Opin Pharmacol 2009, 9:208-213.
4. 2/Cl-system. An Acad Bras Cienc 2015, 87(1):183-192.
5. Wu CC, Wang SH, Kuan II, Tseng WK, Chen MF, Wu JC, et al. OxLDL upregulates caveolin-1 expression in macrophages: role for caveolin-1 in the adhesion of oxLDL-treated macrophages to endothelium. J Cell Biochem 2009, 107:460-472.
6. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, et al. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A 2012, 109:14007-14012.
7. Zhai YP, Lu Q, Liu YW, Cheng Q, Wei YQ, Zhang F, et al. Over-production of nitric oxide by oxidative stress induced activation of the TGF-β1/PI3K/Akt pathway in mesangial cells cultured in high glucose. Acta Pharmacol Sin 2013, 34:507-514.
8. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stafanadis C The role of nitric oxide on endothelial function. Curr Vasc Pharmacol 2012, 10:4-18.
9. Li H, Horke S, Forstermann U Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014, 237:208-219.
10. Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R Antioxidant properties of Garcinia mangostana L (mangosteen) rind. Procedia Chem 2014, 13:198-203.
11. Buelna-Chontal M, Correa F, Hernández-Reséndiz S, Zazueta C, Pedraza-Chaverri J Protective effect of a-mangostin on cardiac reperfusion damageby attenuation of oxidative stress. J Med Food 2011, 14(11):1370-1374.
12. Lin J, Gao Y, Li H, Zhang L, Li X DNA protective effect of mangosteen xanthones: an in vitro study on possible mechanisms. Adv Pharm Bull 2014, 4(2):147-153.
13. Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, et al. Xanthones from mangosteen inhibit inflammation in human macrophages and inhuman adipocytes exposed to macrophage-conditioned media. J Nutr 2010, 140:842-847.
14. Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D Cathecins in ethanolic extracts of Garcinia mangostana fruit pericarp and anti-inflammatory effect in atherosclerotic rats. J Exp Integr Med 2013, 3(2):137-140.
15. Mohora M, Greabu M, Totan A, Mitrea N, Battino M Redox-sensitive signaling factors and antioxidants. Farmacia 2009, 54:399-411.
16. Lubrano V, Balzan S LOX-1 and ROS, inseparable factors in the process of endothelial damage. Free Radic Res 2014, 48(8):841-848.
17. Oliveira-Marques V, Silva T, Cunha F, Covas G, Marinho HS, Antunes F, et al. A quantitative study of the cell-type specific modulation of c-Rel by hydrogen peroxide and TNF-α. Redox Biol 2013, 1:347-352.
18. Gölz L, Memmert S, Rath-Deschner B, Jäger A, Appel T, Baumgarten G, et al. Hypoxia and P. gingivalis synergistically induce HIF-1 and NF-κB activation in PDL cells and periodontal diseases. Mediat Inflamm 2015, 10.1155/2015/438085.
19. Mudau M, Genis A, Lochner A, Strijdom H Endothelial dysfunction: the early predictor ofatherosclerosis. Cardiovasc J Afr 2012, 23:222-231.
20. Susanti E, Rudijanto A, Ratnawati R Catechins inhibit atherosclerosis in male rats on a high fat diet. Universa Medicina 2012, 31:81-87.
21. Adiputro DL, Widodo MA, Romdoni R, Sargowo D Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid. Universa Medicina 2013, 32:37-43.
22. Adiputro DL, Khotimah H, Widodo MA, Romdoni R, Sargowo D Effects of ethanolic extracts of Garcinia mangostana fruit pericarp on oxidant-antioxidant status and foam cellsin atherosclerotic rats. Oxid Antioxid Med Sci 2013, 2(1):61-64.
23. Shen Q, Chitchumroonchokchai C, Thomas JL, Gushchina LV, Disilvestro D, Faila ML, et al. Adipocyte reporter assays: application for identification of antiinflammatoryand antioxidant properties of mangostinxanthones. Mol Nutr Food Res 2014, 58(2):239-247.
24. Teixeira M, Cerqueira F, Barbosa CM, Nascimento MS, Pinto M Improvement of the inhibitory effect of xanthones on NO production by encapsulation in PLGA nanocapsules. J Drug Target 2005, 13(2):129-135.
25. Chen LG, Yang LL, Wang CC Anti-inflammatory activityof mangostins from Garcinia mangostana. Food Chem Toxicol 2008, 46:688-693.
26. Thomas SR, Chen K, Keaney JF Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem 2002, 277:6017-6024.