Pharmacological chaperone for α-crystallin partially restores transparency in cataract models

Science

Volumn 350, Issue 6261, 2015, Pages 674-677

  Makley, Leah N ^a   McMenimen, Kathryn A ^a   DeVree, Brian T ^a   Goldman, Joshua W ^b   McGlasson, Brittney N ^b   Rajagopal, Ponni ^c   Dunyak, Bryan M ^a   McQuade, Thomas J ^d   Thompson, Andrea D ^a   Sunahara, Roger ^a   Klevit, Rachel E ^c   Andley, Usha P ^b   Gestwicki, Jason E ^a,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; CHAPERONE; LANOSTEROL; 25-HYDROXYCHOLESTEROL; AMYLOID; CHOLESTEROL DERIVATIVE; CRYAB PROTEIN, MOUSE;

AGE; BLINDNESS; CRYSTALLINITY; DRUG; MOLECULAR ANALYSIS; NUMERICAL MODEL; PROTEIN; RODENT;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CATARACT; CONTROLLED STUDY; EX VIVO STUDY; EXPERIMENTAL MODEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LENS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; THERMOSTABILITY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DISEASE MODEL; DRUG EFFECTS; GENE TARGETING; GENETICS; PROTEIN CONFORMATION; PROTEIN STABILITY;

MUS;

ALPHA-CRYSTALLIN A CHAIN; ALPHA-CRYSTALLIN B CHAIN; AMYLOID; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CATARACT; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HUMANS; HYDROXYCHOLESTEROLS; MICE; PROTEIN CONFORMATION; PROTEIN STABILITY;

EID: 84947208872     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac9145     Document Type: Article

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