The potential role of inflammation associated with interaction between osteopontin and CD44 in a case of pulmonary tumor thrombotic microangiopathy caused by breast cancer

Internal Medicine

Volumn 54, Issue 22, 2015, Pages 2877-2880

  Higashi, Akifumi ^a   Dohi, Yoshihiro ^a   Uraoka, Naohiro ^a   Sentani, Kazuhiro ^a   Uga, Sayuri ^a   Kinoshita, Hiroki ^a   Sada, Yoshiharu ^a   Kitagawa, Toshiro ^a   Hidaka, Takayuki ^a   Kurisu, Satoshi ^a   Yamamoto, Hideya ^a   Yasui, Wataru ^a   Kihara, Yasuki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

CD44; Osteopontin; Pulmonary hypertension; Pulmonary tumor thrombotic microangiopathy

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD68 ANTIGEN; ENDOTHELIN RECEPTOR ANTAGONIST; HERMES ANTIGEN; METHYLPREDNISOLONE; OSTEOPONTIN; PREDNISOLONE; VASCULOTROPIN;

ARTICLE; AUTOPSY; BREAST CANCER; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; HEART FAILURE; HISTOPATHOLOGY; HYPOXIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG SCINTISCANNING; LUNG TUMOR; MASTECTOMY; POSITRON EMISSION TOMOGRAPHY; PULMONARY HYPERTENSION; PULMONARY TUMOR THROMBOTIC MICROANGIOPATHY; SKIN BIOPSY; TACHYCARDIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; TRANSTHORACIC ECHOCARDIOGRAPHY; URINE VOLUME; AGED; BLOOD; BREAST TUMOR; CASE REPORT; COMPLICATION; FATALITY; FEMALE; HUMAN; LUNG; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; THROMBOTIC MICROANGIOPATHIES; TUMOR EMBOLISM;

AGED; AUTOPSY; BREAST NEOPLASMS; FATAL OUTCOME; FEMALE; HUMANS; INFLAMMATION; LUNG; LUNG NEOPLASMS; NEOPLASTIC CELLS, CIRCULATING; OSTEOPONTIN; THROMBOTIC MICROANGIOPATHIES;

EID: 84947087342     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.54.4749     Document Type: Article

References (12)

1. von Herbay A, Illes A, Waldherr R, Otto HF. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer 66: 587-592, 1990.
2. Sato Y, Marutsuka K, Asada Y, Yamada M, Setoguchi T, Sumiyoshi A. Pulmonary tumor thrombotic microangiopathy. Pathol Int 45: 436-440, 1995.
3. Pinckard JK, Wick MR. Tumor-related thrombotic pulmonary microangiopathy: review of pathologic findings and pathophysiologic mechanisms. Ann Diagn Pathol 4: 154-157, 2000.
4. Uruga H, Fujii T, Kurosaki A, et al. Pulmonary tumor thrombotic microangiopathy: a clinical analysis of 30 autopsy cases. Intern Med 52: 1317-1323, 2013.
5. Fujishiro T, Shuto K, Shiratori T, et al. A case report of pulmonary tumor thrombotic microangiopathy (PTTM) caused by esophageal squamous cell carcinoma. Esophagus 10: 247-251, 2013.
6. Miyano S, Izumi S, Takeda Y, et al. Pulmonary tumor thrombotic microangiopathy. J Clin Oncoly 25: 597-599, 2007.
7. Bhuvaneswaran JS, Venkitachalam CG, Sandhyamani S. Pulmonary wedge aspiration cytology in the diagnosis of recurrent tumour embolism causing pulmonary arterial hypertension. Int J Cardiol 39: 209-212, 1993.
8. Denhardt DT, Noda M, O’Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107: 1055-1061, 2001.
9. Takahashi F, Kumasaka T, Nagaoka T, et al. Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol Int 59: 752-756, 2009.
10. Khan SA, Cook AC, Kappil M, et al. Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel posttranscriptional, post-translational regulation. Clin Exp Metastasis 22: 663-673, 2005.
11. Chan SY, Loscalzo J. Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol 44: 14-30, 2008.
12. Crawford HC, Matrisian LM, Liaw L. Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo. Cancer Res 58: 5206-5215, 1998.