Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

Placenta

Volumn 36, Issue 11, 2015, Pages 1246-1253

  Gierman, L M ^a   Stodle G S ^a,b   Tangeras L H ^a,b   Austdal, M ^a,b   Olsen, G D ^a   Follestad, T ^a   Skei, B ^a   Rian, K ^a   Gundersen, A S ^a   Austgulen, R ^a   Iversen, A C ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cell line; Cytokine; Inflammation; Placenta; Toll like receptor; Trophoblast

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN 9; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; CYTOKINE;

ARTICLE; CHORIOCARCINOMA; CHORIOCARCINOMA CELL LINE; CYTOKINE RELEASE; CYTOKINE RESPONSE; EMBRYO; FETUS DEVELOPMENT; FIRST TRIMESTER PREGNANCY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS REGULATION; SIMIAN VIRUS 40; TROPHOBLAST; CELL LINE; COMPARATIVE STUDY; METABOLISM;

CELL LINE; CYTOKINES; HUMANS; TOLL-LIKE RECEPTORS; TROPHOBLASTS;

EID: 84947046734     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2015.09.004     Document Type: Article

References (44)

1. A. Moffett, and Y.W. Loke The immunological paradox of pregnancy: a reappraisal Placenta 25 1 2004 1 8
2. C.W. Redman, and I.L. Sargent Preeclampsia and the systemic inflammatory response Semin. Nephrol. 24 6 2004 565 570
3. B. Huppertz The anatomy of the normal placenta J. Clin. Pathol. 61 12 2008 1296 1302
4. K. Takeda, T. Kaisho, and S. Akira Toll-like receptors Annu. Rev. Immunol. 21 2003 335 376
5. V.M. Abrahams, P. Bole-Aldo, Y.M. Kim, S.L. Straszewski-Chavez, T. Chaiworapongsa, R. Romero, and G. Mor Divergent trophoblast responses to bacterial products mediated by TLRs J. Immunol. 173 7 2004 4286 4296
6. P.B. Aldo, M.J. Mulla, R. Romero, G. Mor, and V.M. Abrahams Viral ssRNA induces first trimester trophoblast apoptosis through an inflammatory mechanism Am. J. Reprod.Immunol. 64 1 2010 27 37
7. L.H. Tangeras, G.S. Stodle, G.D. Olsen, A.H. Leknes, A.S. Gundersen, B. Skei, A.J. Vikdal, L. Ryan, B. Steinkjer, M.F. Myklebost, M. Langaas, R. Austgulen, and A.C. Iversen Functional toll-like receptors in primary first-trimester trophoblasts J. Reprod. Immunol. 106 2014 89 99
8. Y. Ma, G. Mor, V.M. Abrahams, I.A. Buhimschi, C.S. Buhimschi, and S. Guller Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide Am. J. Reprod.Immunol. 55 1 2006 12 18
9. N.W. Lucchi, and J.M. Moore LPS induces secretion of chemokines by human syncytiotrophoblast cells in a MAPK-dependent manner J. Reprod. Immunol. 73 1 2007 20 27
10. M. Mitsunari, S. Yoshida, T. Shoji, S. Tsukihara, T. Iwabe, T. Harada, and N. Terakawa Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells J. Reprod. Immunol. 72 1-2 2006 46 59
11. A. Pineda, S.L. Verdin-Teran, A. Camacho, and L. Moreno-Fierros Expression of toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia Arch. Med. Res. 42 5 2011 382 391
12. E. Rindsjo, U. Holmlund, E. Sverremark-Ekstrom, N. Papadogiannakis, and A. Scheynius Toll-like receptor-2 expression in normal and pathologic human placenta Hum. Pathol. 38 3 2007 468 473
13. K. Koga, G. Izumi, G. Mor, T. Fujii, and Y. Osuga Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy complications Am. J. Reprod. Immunol. 72 2 2014 192 205
14. M. Hemberger Health during pregnancy and beyond: fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success Ann. Med. 44 4 2012 325 337
15. A. King, L. Thomas, and P. Bischof Cell culture models of trophoblast II: trophoblast cell lines-a workshop report Placenta 21 Suppl. A 2000 S113 S119
16. R.A. Pattillo, G.O. Gey, E. Delfs, and R.F. Mattingly Human hormone production in vitro Science 159 3822 1968 1467 1469
17. R.A.R.A. Pattillo, R. Hussa, R. Bernstein, and E. Delfs The jar cell line-continuous human multihormone production and controls In Vitro 6 1971 398 399
18. P.O. Kohler, and W.E. Bridson Isolation of hormone-producing clonal lines of human choriocarcinoma J. Clin. Endocrinol. Metab. 32 5 1971 683 687
19. H.G. Frank, B. Gunawan, I. Ebeling-Stark, H.J. Schulten, H. Funayama, U. Cremer, B. Huppertz, G. Gaus, P. Kaufmann, and L. Fuzesi Cytogenetic and DNA-fingerprint characterization of choriocarcinoma cell lines and a trophoblast/choriocarcinoma cell hybrid Cancer Genet. Cytogenet. 116 1 2000 16 22
20. U. Hiden, C. Wadsack, N. Prutsch, M. Gauster, U. Weiss, H.G. Frank, U. Schmitz, C. Fast-Hirsch, M. Hengstschlager, A. Potgens, A. Ruben, M. Knofler, P. Haslinger, B. Huppertz, M. Bilban, P. Kaufmann, and G. Desoye The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations-TNF-alpha stimulates MMP15 expression BMC Dev. Biol. 7 2007 137
21. H. Funayama, G. Gaus, I. Ebeling, M. Takayama, L. Füzesi, B. Huppertz, P. Kaufmann, and H.G. Frank Parent cells for trophoblast hybridization II: AC1 and related trophoblast cell lines, a family of HGPRT-negative mutants of the choriocarcinoma cell line JEG-3 Placenta 18 1997 191 201
22. C.H. Graham, T.S. Hawley, R.C. Hawley, J.R. MacDougall, R.S. Kerbel, N. Khoo, and P.K. Lala Establishment and characterization of first trimester human trophoblast cells with extended lifespan Exp. Cell Res. 206 2 1993 204 211
23. M.Y. Choy, and I.T. Manyonda The phagocytic activity of human first trimester extravillous trophoblast Hum. Reprod. 13 10 1998 2941 2949
24. J.P. Steibel, R. Poletto, P.M. Coussens, and G.J. Rosa A powerful and flexible linear mixed model framework for the analysis of relative quantification RT-PCR data Genomics 94 2 2009 146 152
25. O. Equils, D. Lu, M. Gatter, S.S. Witkin, C. Bertolotto, M. Arditi, J.A. McGregor, C.F. Simmons, and C.J. Hobel Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4 J. Immunol. 177 2 2006 1257 1263
26. D. Klaffenbach, W. Rascher, M. Rollinghoff, J. Dotsch, U. Meissner, and M. Schnare Regulation and signal transduction of toll-like receptors in human chorioncarcinoma cell lines Am. J. Reprod. Immunol. 53 2 2005 77 84
27. K. Fujisawa, K. Nasu, K. Arima, T. Sugano, H. Narahara, and I. Miyakawa Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo Placenta 21 4 2000 354 360
28. S. Komine-Aizawa, H. Majima, C. Yoshida-Noro, and S. Hayakawa Stimuli through toll-like receptor (TLR) 3 and 9 affect human chorionic gonadotropin (hCG) production in a choriocarcinoma cell line J. Obstet. Gynaecol. Res. 34 2 2008 144 151
29. A.L. Blasius, and B. Beutler Intracellular toll-like receptors Immunity 32 3 2010 305 315
30. N.K.S. Khoo, J.F. Bechberger, T. Shepherd, S.L. Bond, K.R. McCrae, G.S. Hamilton, and P.K. Lala SV40 tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasivess and resistance to anti-invasive action of TGFβ Int. J. Cancer 77 3 1998 429 439
31. R. Raghupathy Cytokines as key players in the pathophysiology of preeclampsia Med. Princ. Pract. 22 Suppl. 1 2013 8 19
32. M.B. Pinheiro, O.A. Martins-Filho, A.P.L. Mota, P.N. Alpoim, L.C. Godoi, A.C.O. Silveira, A. Teixeira-Carvalho, K.B. Gomes, and L.M. Dusse Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state Cytokine 62 1 2013 165 173
33. V.M. Abrahams, T.M. Schaefer, J.V. Fahey, I. Visintin, J.A. Wright, P.B. Aldo, R. Romero, C.R. Wira, and G. Mor Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, poly(I:C) Hum. Reprod. 21 9 2006 2432 2439
34. W. Xu, G. Yang, J. Duan, Y. Wang, W. Yao, X. Liu, X. Chen, Y. Ding, Y. Wang, and J. He Effects of toll-like receptors on indoleamine 2,3-dioxygenase mRNA levels in human trophoblast HTR-8/SVneo cells J. South. Med. Univ. 33 11 2013 1559 1564
35. V.M. Abrahams, I. Visintin, P.B. Aldo, S. Guller, R. Romero, and G. Mor A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells J. Immunol. 175 12 2005 8096 8104
36. G. Chan, and L.J. Guilbert Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a toll-like receptor-2 and tumour necrosis factor-alpha dependent manner J. Pathol. 210 1 2006 111 120
37. A. Uh, R.C. Nicholson, G.V. Gonzalez, C.F. Simmons, A. Gombart, R. Smith, and O. Equils Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing hormone expression through MyD88 Am. J. Obstet. Gynecol. 199 3 2008 317.e1 317.e6
38. R. Apps, S.P. Murphy, R. Fernando, L. Gardner, T. Ahad, and A. Moffett Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies Immunology 127 1 2009 26 39
39. B. Novakovic, L. Gordon, N.C. Wong, A. Moffett, U. Manuelpillai, J.M. Craig, A. Sharkey, and R. Saffery Wide ranging DNA methylation differences of primary trophoblast cell populations and derived-cell lines: implications and opportunities for understanding trophoblast function Mol. Hum. Reprod. 17 6 2011 344 353
40. G.L. Vegh, V. Fulop, Y. Liu, S.-W. Ng, Z.S. Tuncer, D.R. Genest, P. Paldi-Haris, J. Foldi, S.C. Mok, and R.S. Berkowitz Differential gene expression pattern between normal human trophoblast and choriocarcinoma cell lines: downregulation of heat shock protein-27 in choriocarcinoma in vitro and in vivo Gynecol. Oncol. 75 3 1999 391 396
41. M. Bilban, S. Tauber, P. Haslinger, J. Pollheimer, L. Saleh, H. Pehamberger, O. Wagner, and M. Knofler Trophoblast invasion: assessment of cellular models using gene expression signatures Placenta 31 11 2010 989 996
42. D.M. Morales-Prieto, W. Chaiwangyen, S. Ospina-Prieto, U. Schneider, J. Herrmann, B. Gruhn, and U.R. Markert MicroRNA expression profiles of trophoblastic cells Placenta 33 9 2012 725 734
43. M.H. Sullivan Endocrine cell lines from the placenta Mol. Cell. Endocrinol. 228 1-2 2004 103 119
44. I.T. Manyonda, G.S. Whitley, and J.E. Cartwright Trophoblast cell lines: a response to the workshop report by King et al Placenta 22 2-3 2001 262 263