Deletions in a ribosomal protein-coding gene are associated with tigecycline resistance in Enterococcus faecium

International Journal of Antimicrobial Agents

Volumn 46, Issue 5, 2015, Pages 572-575

  Niebel, Marc ^a   Quick, Joshua ^a,b   Prieto, Ana Maria Guzman ^c   Hill, Robert L R ^d   Pike, Rachel ^d   Huber, Damon ^b   David, Miruna ^a   Hornsey, Michael ^e   Wareham, David ^f   Oppenheim, Beryl ^a   Woodford, Neil ^d   Van Schaik, Willem ^c   Loman, Nicholas ^b  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

^e UNIVERSITY OF ROEHAMPTON   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Enterococcus; Resistance; Tigecycline; Whole genome sequencing

Indexed keywords

TIGECYCLINE; ANTIINFECTIVE AGENT; BACTERIAL DNA; MINOCYCLINE; RIBOSOME PROTEIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIUM ISOLATE; BINDING SITE; CONTROLLED STUDY; ENTEROCOCCUS FAECIUM; GENE DELETION; GENE MUTATION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; RPSJ GENE; SEQUENCE ANALYSIS; ANALOGS AND DERIVATIVES; CHEMISTRY; DNA SEQUENCE; DRUG EFFECTS; GENETICS; GRAM-POSITIVE BACTERIAL INFECTIONS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR GENETICS;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; GENOME, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MOLECULAR SEQUENCE DATA; RIBOSOMAL PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION;

EID: 84947046568     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.07.009     Document Type: Article

References (15)

1. C.A. Arias, and B.E. Murray The rise of the Enterococcus: beyond vancomycin resistance Nat Rev Microbiol 10 2012 266 278
2. M.S. Gilmore, D.B. Clewell, Y. Ike, and N. Shankar Enterococci: from commensals to leading causes of drug resistant infection 2014 Massachusetts Eye and Ear Infirmary Boston, MA
3. Y. Sun, Y. Cai, X. Liu, N. Bai, B. Liang, and R. Wang The emergence of clinical resistance to tigecycline Int J Antimicrob Agents 41 2013 110 116
4. M. Hornsey, N. Loman, D.W. Wareham, M.J. Ellington, M.J. Pallen, J.F. Turton, and et al. Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy J Antimicrob Chemother 66 2011 1499 1503
5. C. Rodríguez-Avial, I. Rodríguez-Avial, P. Merino, and J.J. Picazo Klebsiella pneumoniae: development of a mixed population of carbapenem and tigecycline resistance during antimicrobial therapy in a kidney transplant patient Clin Microbiol Infect 18 2012 61 66
6. C. Cordina, R. Hill, A. Deshpande, J. Hood, and T. Inkster Tigecycline-resistant Enterococcus faecalis associated with omeprazole use in a surgical patient J Antimicrob Chemother 67 2012 1806 1807
7. A.N.G. Dabul, and I.L.B.C. Camargo Molecular characterization of methicillin-resistant Staphylococcus aureus resistant to tigecycline and daptomycin isolated in a hospital in Brazil Epidemiol Infect 142 2014 479 483
8. D. Keeney, A. Ruzin, F. McAleese, E. Murphy, and P.A. Bradford MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli J Antimicrob Chemother 61 2008 46 53
9. L. Villa, C. Feudi, D. Fortini, A. García-Fernández, and A. Carattoli Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance Antimicrob Agents Chemother 58 2014 1707 1712
10. British Society for Antimicrobial Chemotherapy Standing Committee on Susceptibility Testing. Version 13.0, 10-06-2014 2014 BSAC http://bsac.org.uk/wp-content/uploads/2012/02/BSAC-Susceptibility-testing-version-131.pdf [accessed 05.08.14]
11. V. Cattoir, C. Isnard, T. Cosquer, A. Odhiambo, F. Bucquet, F. Guérin, and et al. Genomic analysis of reduced susceptibility to tigecycline in Enterococcus faecium Antimicrob Agents Chemother 59 2015 239 244
12. L. Jenner, A.L. Starosta, D.S. Terry, A. Mikolajka, L. Filonava, M. Yusupov, and et al. Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis Proc Natl Acad Sci U S A 110 2013 3812 3816
13. V. Anantharaman, and L. Aravind The NYN domains: novel predicted RNAses with a PIN domain-like fold RNA Biol 3 2006 18 27
14. N.J. Loman, R.V. Misra, T.J. Dallman, C. Constantinidou, S.E. Gharbia, J. Wain, and et al. Performance comparison of benchtop high-throughput sequencing platforms Nat Biotechnol 30 2012 434 439 [Erratum in: Nat Biotechnol 2012; 30:562]
15. M. Miyamoto, D. Motooka, K. Gotoh, T. Imai, K. Yoshitake, N. Goto, and et al. Performance comparison of second- and third-generation sequencers using a bacterial genome with two chromosomes BMC Genomics 15 2014 699