Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families

Neurobiology of Aging

Volumn 36, Issue 11, 2015, Pages 3116.e9-3116.e16

  Barral, Sandra ^a,b   Vardarajan, Badri N ^a,b   Reyes Dumeyer, Dolly ^a,b   Faber, Kelley M ^c   Bird, Thomas D ^d   Tsuang, Debby ^d   Bennett, David A ^e   Rosenberg, Roger ^f   Boeve, Bradley F ^g   Graff Radford, Neill R ^h   Goate, Alison M ⁱ   Farlow, Martin ^c   Lantigua, Rafael ^a   Medrano, Martin Z ^j   Wang, Xinbing ^k,l   Kamboh, M Ilyas ^k   Barmada, Mahmud Muhiedine ^k   Schaid, Daniel J ^g   Foroud, Tatiana M ^c   Weamer, Elise A ^m   Ottman, Ruth ^a,b,n   Sweet, Robert A ^m,o   Mayeux, Richard ^a,b   more..

^a Department of Medicine   (United States)

^b Vagelos College of Physicians and Surgeons   (United States)

^c INDIANA UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g MAYO CLINIC   (United States)

^h MAYO CLINIC   (United States)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^j Pontificia Universidad Catolica Madre y Maestra   (Dominican Republic)

^k UNIVERSITY OF PITTSBURGH   (United States)

^l UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^m UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁿ NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^o VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

Association analysis; Genome wide linkage analysis; Late onset Alzheimer's disease; Non Hispanic Caucasian and Caribbean Hispanic ancestry populations; Psychosis

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN DEVELOPMENT; CHROMOSOME 13; CHROMOSOME 19Q; COMORBIDITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNICITY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOSIS; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; CAUCASIAN; CHROMOSOME 19; COHORT ANALYSIS; COMPLICATION; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; INFORMATION PROCESSING; META ANALYSIS (TOPIC); MIDDLE AGED; PSYCHOTIC DISORDERS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHROMOSOMES, HUMAN, PAIR 19; COHORT STUDIES; DATASETS AS TOPIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOTIC DISORDERS;

EID: 84947045063     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.08.006     Document Type: Article

References (39)

1. Abecasis G.R., Cherny S.S., Cookson W.O., Cardon L.R. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 2002, 30:97-101.
2. Avramopoulos D., Fallin M.D., Bassett S.S. Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 132B:9-13.
3. Bacanu S.A., Devlin B., Chowdari K.V., DeKosky S.T., Nimgaonkar V.L., Sweet R.A. Linkage analysis of Alzheimer disease with psychosis. Neurology 2002, 59:118-120.
4. Bacanu S.A., Devlin B., Chowdari K.V., DeKosky S.T., Nimgaonkar V.L., Sweet R.A. Heritability of psychosis in Alzheimer disease. Am. J. Geriatr. Psychiatry 2005, 13:624-627.
5. Bassiony M.M., Steinberg M.S., Warren A., Rosenblatt A., Baker A.S., Lyketsos C.G. Delusions and hallucinations in Alzheimer's disease: prevalence and clinical correlates. Int. J. Geriatr. Psychiatry 2000, 15:99-107.
6. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
7. Demichele-Sweet M.A., Lopez O.L., Sweet R.A. Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein e. Int. J. Alzheimers Dis. 2011, 2011:926597.
8. DeMichele-Sweet M.A., Sweet R.A. Genetics of psychosis in Alzheimer's disease: a review. J. Alzheimers Dis. 2010, 19:761-780.
9. Gertz E.M., Hiekkalinna T., Digabel S.L., Audet C., Terwilliger J.D., Schaffer A.A. PSEUDOMARKER 2.0: efficient computation of likelihoods using NOMAD. BMC Bioinformatics 2014, 15:47.
10. Go R.C., Perry R.T., Wiener H., Bassett S.S., Blacker D., Devlin B., Sweet R.A. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 139B:28-32.
11. Graff M., Fernandez-Rhodes L., Liu S., Carlson C., Wassertheil-Smoller S., Neuhouser M., Reiner A., Kooperberg C., Rampersaud E., Manson J.E., Kuller L.H., Howard B.V., Ochs-Balcom H.M., Johnson K.C., Vitolins M.Z., Sucheston L., Monda K., North K.E. Generalization of adiposity genetic loci to US Hispanic women. Nutr. Diabetes 2013, 3:e85.
12. Hollingworth P., Hamshere M.L., Holmans P.A., O'Donovan M.C., Sims R., Powell J., Lovestone S., Myers A., DeVrieze F.W., Hardy J., Goate A., Owen M., Williams J. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:841-848.
13. Hollingworth P., Sweet R., Sims R., Harold D., Russo G., Abraham R., Stretton A., Jones N., Gerrish A., Chapman J., Ivanov D., Moskvina V., Lovestone S., Priotsi P., Lupton M., Brayne C., Gill M., Lawlor B., Lynch A., Craig D., McGuinness B., Johnston J., Holmes C., Livingston G., Bass N.J., Gurling H., McQuillin A., Holmans P., Jones L., Devlin B., Klei L., Barmada M.M., Demirci F.Y., DeKosky S.T., Lopez O.L., Passmore P., Owen M.J., O'Donovan M.C., Mayeux R., Kamboh M.I., Williams J. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol. Psychiatry 2012, 17:1316-1327.
14. Kaufer D.I., Cummings J.L., Ketchel P., Smith V., MacMillan A., Shelley T., Lopez O.L., DeKosky S.T. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J. Neuropsychiatry Clin. Neurosci. 2000, 12:233-239.
15. Kim Y., Ha C.M., Chang S. SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons. J. Biol. Chem. 2013, 288:29453-29466.
16. Lander E., Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 1995, 11:241-247.
17. Lopez O.L., Wisniewski S.R., Becker J.T., Boller F., DeKosky S.T. Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease. Arch. Neurol. 1999, 56:1266-1272.
18. Mack J.L., Patterson M.B., Tariot P.N. Behavior Rating Scale for Dementia: development of test scales and presentation of data for 555 individuals with Alzheimer's disease. J. Geriatr. Psychiatry Neurol. 1999, 12:211-223.
19. Mayeux R., Small S.A., Tang M., Tycko B., Stern Y. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol. Aging 2001, 22:683-689.
20. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
21. Morris A.P. Transethnic meta-analysis of genomewide association studies. Genet. Epidemiol. 2011, 35:809-822.
22. Morton N.E. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am. J. Hum. Genet. 1956, 8:80-96.
23. Nicholas A.K., Khurshid M., Desir J., Carvalho O.P., Cox J.J., Thornton G., Kausar R., Ansar M., Ahmad W., Verloes A., Passemard S., Misson J.P., Lindsay S., Gergely F., Dobyns W.B., Roberts E., Abramowicz M., Woods C.G. WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nat. Genet. 2010, 42:1010-1014.
24. Ott J. Computer-simulation methods in human linkage analysis. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:4175-4178.
25. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 1999, 56:303-308.
26. Scarmeas N., Brandt J., Albert M., Hadjigeorgiou G., Papadimitriou A., Dubois B., Sarazin M., Devanand D., Honig L., Marder K., Bell K., Wegesin D., Blacker D., Stern Y. Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch. Neurol. 2005, 62:1601-1608.
27. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511:421-427. Schizophrenia Working Group of the Psychiatric Genomics Consortium.
28. Steinberg S., Mors O., Borglum A.D., Gustafsson O., Werge T., Mortensen P.B., Andreassen O.A., Sigurdsson E., Thorgeirsson T.E., Bottcher Y., Olason P., Ophoff R.A., Cichon S., Gudjonsdottir I.H., Pietilainen O.P., Nyegaard M., Tuulio-Henriksson A., Ingason A., Hansen T., Athanasiu L., Suvisaari J., Lonnqvist J., Paunio T., Hartmann A., Jurgens G., Nordentoft M., Hougaard D., Norgaard-Pedersen B., Breuer R., Moller H.J., Giegling I., Glenthoj B., Rasmussen H.B., Mattheisen M., Bitter I., Rethelyi J.M., Sigmundsson T., Fossdal R., Thorsteinsdottir U., Ruggeri M., Tosato S., Strengman E., Kiemeney L.A., Melle I., Djurovic S., Abramova L., Kaleda V., Walshe M., Bramon E., Vassos E., Li T., Fraser G., Walker N., Toulopoulou T., Yoon J., Freimer N.B., Cantor R.M., Murray R., Kong A., Golimbet V., Jonsson E.G., Terenius L., Agartz I., Petursson H., Nothen M.M., Rietschel M., Peltonen L., Rujescu D., Collier D.A., Stefansson H., St Clair D., Stefansson K. Expanding the range of ZNF804A variants conferring risk of psychosis. Mol. Psychiatry 2011, 16:59-66.
29. Sweet R.A., Bennett D.A., Graff-Radford N.R., Mayeux R. Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study. Brain 2010, 133(Pt 4):1155-1162.
30. Sweet R.A., Hamilton R.L., Lopez O.L., Klunk W.E., Wisniewski S.R., Kaufer D.I., Healy M.T., DeKosky S.T. Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features. Int. Psychogeriatr. 2000, 12:547-558.
31. Sweet R.A., Panchalingam K., Pettegrew J.W., McClure R.J., Hamilton R.L., Lopez O.L., Kaufer D.I., DeKosky S.T., Klunk W.E. Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology. Neurobiol. Aging 2002, 23:547-553.
32. Sweet R.A., Seltman H., Emanuel J.E., Lopez O.L., Becker J.T., Bis J.C., Weamer E.A., DeMichele-Sweet M.A., Kuller L.H. Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study. Am. J. Psychiatry 2012, 169:954-962.
33. Thies W., Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013, 9:208-245. Alzheimer's Association.
34. Urrutia R. KRAB-containing zinc-finger repressor proteins. Genome Biol. 2003, 4:231.
35. Vardarajan B.N., Faber K.M., Bird T.D., Bennett D.A., Rosenberg R., Boeve B.F., Graff-Radford N.R., Goate A.M., Farlow M., Sweet R.A., Lantigua R., Medrano M.Z., Ottman R., Schaid D.J., Foroud T.M., Mayeux R. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). JAMA Neurol. 2014, 71:315-323. NIA-LOAD/NCRAD Family Study Group.
36. Wijsman E.M., Pankratz N.D., Choi Y., Rothstein J.H., Faber K.M., Cheng R., Lee J.H., Bird T.D., Bennett D.A., Diaz-Arrastia R., Goate A.M., Farlow M., Ghetti B., Sweet R.A., Foroud T.M., Mayeux R. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet. 2011, 7:e1001308.
37. Wilson R.S., Tang Y., Aggarwal N.T., Gilley D.W., McCann J.J., Bienias J.L., Evans D.A. Hallucinations, cognitive decline, and death in Alzheimer's disease. Neuroepidemiology 2006, 26:68-75.
38. Xu B., Roos J.L., Levy S., van Rensburg E.J., Gogos J.A., Karayiorgou M. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat. Genet. 2008, 40:880-885.
39. Zheng X., Demirci F.Y., Barmada M.M., Richardson G.A., Lopez O.L., Sweet R.A., Kamboh M.I., Feingold E. Genome-wide copy-number variation study of psychosis in Alzheimer's disease. Transl. Psychiatry 2015, 5:e574.