TLR2, TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis

Journal of Oral Pathology and Medicine

Volumn 44, Issue 10, 2015, Pages 857-863

  Karasneh, Jumana ^a   Bani Hani, Maisoun ^a   Alkhateeb, Asem ^a   Hassan, Ahmad ^b   Alzoubi, Firas ^c   Thornhill, Martin ^d  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^b MUSTANSIRIYAH UNIVERSITY   (Iraq)

^c KING ABDULLAH UNIVERSITY HOSPITAL   (Jordan)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Co stimulatory protein; Polymorphism; Recurrent aphthous stomatitis; Toll like receptor

Indexed keywords

CD86 ANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; CD86 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR;

ALLELE; APHTHOUS STOMATITIS; ARTICLE; CONTROLLED STUDY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; JURISPRUDENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; ANTIGENS, CD86; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; STOMATITIS, APHTHOUS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; WILLS;

EID: 84947042031     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/jop.12298     Document Type: Article

References (33)

1. Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp 2014; 62: 205-15.
2. Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther 2010; 23: 281-90.
3. Lehner T. Immunological aspects of recurrent oral ulcers. Oral Surg Oral Med Oral Pathol 1972; 33: 80-5.
4. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg 2008; 46: 198-206.
5. Salem C. Prevalence of recurrent aphthous ulceration in Gizan. Saudi Dent J 1992; 4: 106-10.
6. Al-Mobeeriek A, AlDosari AM. Prevalence of oral lesions among Saudi dental patients. Ann Saudi Med 2009; 29: 365-8.
7. Liu Y, Yin H, Zhao M, Lu Q. TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol 2014; 47: 136-47.
8. Hietanen J, Häyrinen-Immonen R, Al-Samadi A, Trokovic N, Koskenpato K, Konttinen YT. Recurrent aphthous ulcers-a Toll-like receptor-mediated disease? J Oral Pathol Med 2012; 41: 158-64.
9. Deniz E, Guc U, Buyukbabani N, Gul A. HSP 60 expression in recurrent oral ulcerations of Behçet's disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 110: 196-200.
10. Hasan A, Shinnick T, Mizushima Y, van der Zee R, Lehner T. Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis. Clin Exp Immunol 2002; 128: 318-25.
11. Tobias P, Curtiss LK. Thematic review series: the immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis. J Lipid Res 2005; 46: 404-11.
12. Qi H, Denning TL, Soong L. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun 2003; 71: 3337-42.
13. Nussbaum G, Ben-Adi S, Genzler T, Sela M, Rosen G. Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components. Infect Immun 2009; 77: 3939-47.
14. Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004; 21: 733-41.
15. Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009; 229: 12-26.
16. de Almeida ER, Petzl-Erler ML. Expression of genes involved in susceptibility to multifactorial autoimmune diseases: estimating genotype effects. Int J Immunogenet 2013; 40: 178-85.
17. Podojil JR, Miller SD. Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev 2009; 229: 337-55.
18. Karasneh JA, Bani-Hani ME, Alkhateeb AM, Hassan AF, Thornhill MH. Association of MMP but not TIMP-1 gene polymorphisms with recurrent aphthous stomatitis. Oral Dis 2013; 20: 693-9.
19. Biswas D, Gupta SK, Sindhwani G, Patras A. TLR2 polymorphisms, Arg753Gln and Arg677Trp, are not associated with increased burden of tuberculosis in Indian patients. BMC Res Notes 2009; 18: 2.
20. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74: 765-9.
21. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-5.
22. Ferronato S, Gomez-Lira M, Menegazzi M, et al. Polymorphism -2604G>A variants in TLR4 promoter are associated with different gene expression level in peripheral blood of atherosclerotic patients. J Hum Genet 2013; 58: 812-14.
23. Budulac SE, Boezen HM, Hiemstra PS, et al. Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease. PLoS ONE 2012; 7: e43124.
24. Singh K, Kant S, Singh VK, Agrawal NK, Gupta SK, Singh K. Toll-like receptor 4 polymorphisms and their haplotypes modulate the risk of developing diabetic retinopathy in type 2 diabetes patients. Mol Vis 2014; 20: 704-13.
25. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-91.
26. Meguro A, Ota M, Katsuyama Y, et al. Association of the Toll-like receptor 4 gene polymorphisms with Behcet's disease. Ann Rheum Dis 2008; 67: 725-7.
27. Horie Y, Meguro A, Ota M, et al. Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Rheumatology 2009; 48: 638-42.
28. Meena NK, Verma R, Verma N, Ahuja V, Paul J. TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis. J Clin Gastroenterol 2013; 47: 773-80.
29. Shen X, Shi R, Zhang H, Li K, Zhao Y, Zhang R. The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis. Digestion 2010; 81: 69-77.
30. Karaca N, Ozturk G, Gerceker BT, Turkmen M, Berdeli A. TLR2 and TLR4 gene polymorphisms in Turkish Vitiligo patients. J Eur Acad Dermatol Venereol 2013; 27: e85-90.
31. Bacanli A, Sallakci N, Yavuzer U, Alpsoy E, Yegin O. Toll-like receptor 2 Arg753Gln gene polymorphism in Turkish patients with Behcet's disease. Clin Exp Dermatol 2006; 31: 699-701.
32. Tomiyama R, Meguro A, Ota M, et al. Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behçet's disease in Japanese patients. Hum Immunol 2009; 70: 41-4.
33. Kirino Y, Takeno M, Watanabe R, et al. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Arthritis Res Ther 2008; 10: R1.