Inflammasome polymorphisms in juvenile systemic lupus erythematosus

Autoimmunity

Volumn 48, Issue 7, 2015, Pages 434-437

  Pontillo, Alessandra ^a   Reis, Edione C ^a   Liphaus, Bernadete L ^a   Silva, Clovis A ^a   Carneiro Sampaio, Magda ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Genetic background; IL 1b; inflammasome; juvenile systemic lupus erythematosus; single nucleotide polymorphisms

Indexed keywords

CARD8 PROTEIN; CRYOPYRIN; DNA ANTIBODY; INFLAMMASOME; INTERLEUKIN 1BETA; NLRP1 PROTEIN; TNFAIP3 PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CARD8 PROTEIN, HUMAN; CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; DNA BINDING PROTEIN; NLRP1 PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TNFAIP3 PROTEIN, HUMAN; TUMOR PROTEIN;

ADOLESCENT; ADOLESCENT DISEASE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATHOGENESIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; ADULT; ALLELE; CASE CONTROL STUDY; CHILD; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; IMMUNOLOGY; PATHOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; AGE OF ONSET; ALLELES; APOPTOSIS REGULATORY PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHILD; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84947031686     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2015.1064399     Document Type: Article

References (21)

1. Rahman, A., and D. A. Isenberg. 2008. Mechanisms of disease: systemic lupus erythematosus. N. Eng. J. Med. 358: 929-939.
2. Choi, J., S. T. Kim, and J. Craft. 2012. The pathogenesis of systemic lupus erythematosus-an update. Curr. Opin. Immunol. 24: 651-657.
3. Carneiro-Sampaio, M., B. L. Liphaus, A. Jesus, et al. 2008. Understanding systemic lupus erythematosus physiopathology in the light of primary immunodeficiencies. J. Clin. Immunol. 28: S34-S41.
4. Hoffman, I. E., B. R. Lauwerys, F. De Keyser, et al. 2009. Juvenileonset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Ann. Rheum. Dis. 68: 412-415.
5. Hochberg, M. C. 1997. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheumat. 40: 1725.
6. Brunner, H. I., D. D. Gladman, D. Ibanez, et al. 2008. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheumat. 58: 556-562.
7. Malattia, C., and A. Martini. 2013. Paediatric-onset systemic lupus erythematosus. Best Pract. Res. Clin. Rheumatol. 27: 351-362.
8. Webb, R., J. A., Kelly, E., Somers, et al. 2011. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. Ann. Rheum. Dis. 70: 151-156.
9. Man, S. M., and T. D. Kanneganti. 2015. Regulation of inflammasome activation. Immunol. Rev. 265: 6-21.
10. Shaw, P. J., M. F. McDermott, and T. D. Kanneganti. 2011. Inflammasomes and autoimmunity. Trends Mol. Med. 17: 57-64.
11. Pontillo, A., M. Girardelli, A. J. Kamada, et al. 2012. Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. Autoimmunity. 45: 271-278.
12. Yang, Q., C. Yu, Yang Z., et al. 2014. Deregulated NLRP3 and NLRP1 inflammasomes and their correlations with disease activity in systemic lupus erythematosus. J. Rheumatol. 41: 444-452.
13. Gladman, D. D., D. Ibanez, and M. B. Urowitz. 2002. Systemic lupus erythematosus disease activity index 2000. J. Rheumatol. 29: 288-291.
14. Santos, R.V., P. H. Fry, S. Monteiro, et al. 2009. Color, race, and genomic ancestry in Brazil: dialogues between anthropology and genetics. Curr. Anthropol. 50: 787-819.
15. Pena, S., G. Di Pietro, M. Fuchshuber-Moraes, et al. 2011. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PLoS One. 6: e17063.
16. Pontillo, A., A. Vendramin, E. Catamo, et al. 2011. The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease. Am. J. Gastroenterol. 106: 539-544.
17. Pontillo, A., T. M. Oshiro, M. Girardelli, et al. 2012. Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection. J. Acquir. Immune. Defic. Syndr. 59: 121-125.
18. Pontillo, A., M. S. Carvalho, A. Kamada, et al. 2013. Susceptibility to Mycobacterium tuberculosis infection in HIV-positive patients is associated with CARD8 genetic variant. J. Acquir. Immune. Defic. Syndr. 63: 147-151.
19. Mele, A., J. R. Cervantes, V. Chien, et al. 2014. Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases. Adv. Exp. Med. Biol. 809: 163-183.
20. Wang, B., J. M. Zhu, Y. Fan, et al. 2013. The association of IL1α and IL1β polymorphisms with susceptibility to systemic lupus erythematosus: a meta-analysis. Gene. 527: 95-101.
21. Pieterse, E., and J., van der Vlag. 2014. Breaking immunological tolerance in systemic lupus erythematosus. Front. Immunol. 5: 164.