Potentially inappropriate prescribing and adverse drug reactions in the elderly: A population-based study

European Journal of Clinical Pharmacology

Volumn 71, Issue 12, 2015, Pages 1525-1533

  Hedna, Khedidja ^a,b   Hakkarainen, Katja M ^b,c   Gyllensten, Hanna ^b,d   Jönsson, Anna K ^a   Petzold, Max ^e   Hägg, Staffan ^a,f  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NORDIC SCHOOL OF PUBLIC HEALTH   (Sweden)

^c EPID Research Oy   (Finland)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f Jonkoping County Council   (Sweden)

Author keywords

Adverse drug reactions; Elderly; Inappropriate prescribing; Medical records; Registries; Retrospective study

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHISTAMINIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; CORTICOSTEROID; ESTROGEN; NEUROLEPTIC AGENT; NITRAZEPAM; NONSTEROID ANTIINFLAMMATORY AGENT; PRESCRIPTION DRUG; VASODILATOR AGENT;

ADVERSE DRUG REACTION; AGED; ANKLE EDEMA; ARTICLE; CARDIOVASCULAR SYSTEM; COHORT ANALYSIS; CONSTIPATION; CONTROLLED STUDY; DIZZINESS; EPILEPSY; FALLING; FATIGUE; FEMALE; HUMAN; HYPOTENSION; INAPPROPRIATE PRESCRIBING; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; NAUSEA; NERVOUS SYSTEM; ORTHOSTATIC HYPOTENSION; PHARMACOEPIDEMIOLOGY; POTENTIALLY INAPPROPRIATE PRESCRIPTIONS; PREVALENCE; PRIMARY HEALTH CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SENESCENCE; SENSITIVITY ANALYSIS; SWEDISH CITIZEN; XEROSTOMIA; CHEMICALLY INDUCED; CLINICAL PRACTICE; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; NERVOUS SYSTEM DISEASES; REGISTER; STANDARDS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; SWEDEN; VASCULAR DISEASES; VERY ELDERLY;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; COHORT STUDIES; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HUMANS; INAPPROPRIATE PRESCRIBING; LOGISTIC MODELS; MALE; NERVOUS SYSTEM DISEASES; PRACTICE PATTERNS, PHYSICIANS'; PREVALENCE; PRIMARY HEALTH CARE; REGISTRIES; RETROSPECTIVE STUDIES; SWEDEN; VASCULAR DISEASES;

EID: 84946899364     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-015-1950-8     Document Type: Article

References (54)

1. World Health Organization WHO (2011) Global health and aging. US National Institute of Aging
2. Maher RL, Hanlon J, Hajjar ER (2014) Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 13:57-65
3. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW (2005) Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 294:716-724
4. Corsonello A, Pedone C, Incalzi RA (2010) Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem 17:571-584
5. Konrat C, Boutron I, Trinquart L, Auleley GR, Ricordeau P, Ravaud P (2012) Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs. PLoS One 7:e33559
6. Krahenbuhl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krahenbuhl S (2007) Drug-related problems in hospitals: a review of the recent literature. Drug Saf 30:379-407
7. Hakkarainen KM, Hedna K, Petzold M, Hagg S (2012) Percentage of patients with preventable adverse drug reactions and preventability of adverse drug reactions - a meta-analysis. PLoS One 7:e33236
8. Hanlon JT, Schmader KE, Ruby CM, Weinberger M (2001) Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc 49:200-209
9. Passarelli MC, Jacob-Filho W, Figueras A (2005) Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging 22:767-777
10. Lau DT, Kasper JD, Potter DE, Lyles A, Bennett RG (2005) Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med 165:68-74
11. Bradley MC, Fahey T, Cahir C, Bennett K, O'Reilly D, Parsons C, Hughes CM (2012) Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland Enhanced Prescribing Database. Eur J Clin Pharmacol 68:1425-1433
12. Dimitrow MS, Airaksinen MS, Kivela SL, Lyles A, Leikola SN (2011) Comparison of prescribing criteria to evaluate the appropriateness of drug treatment in individuals aged 65 and older: a systematic review. J Am Geriatr Soc 59:1521-1530
13. Corsonello A, Onder G, Abbatecola AM, Guffanti EE, Gareri P, Lattanzio F (2012) Explicit criteria for potentially inappropriate medications to reduce the risk of adverse drug reactions in elderly people: from Beers to STOPP/START criteria. Drug Saf 35(Suppl 1):21-28
14. Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D (2008) STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 46:72-83
15. Liu CL, Peng LN, Chen YT, Lin MH, Liu LK, Chen LK (2012) Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study. Arch Gerontol Geriatr 55:148-151
16. Pyszka LL, Seys Ranola TM, Milhans SM (2010) Identification of inappropriate prescribing in geriatrics at a Veterans Affairs hospital using STOPP/START screening tools. Consult Pharm 25:365-373
17. Windsant-van V, den Tweel AM, Verduijn MM, Derijks HJ, van Marum RJ (2012) Detection of inappropriate medication use in the elderly; will the STOPP and START criteria become the new Dutch standards? Ned Tijdschr Geneeskd 156:A5076
18. Alfaro Lara ER, Vega Coca MD, Galvan Banqueri M, Marin Gil R, Nieto Martin MD, Perez Guerrero C, Ollero Baturone M, Santos-Ramos B (2012) Selection of tools for reconciliation, compliance and appropriateness of treatment in patients with multiple chronic conditions. Eur J Intern Med 23:506-512
19. Hill-Taylor B, Sketris I, Hayden J, Byrne S, O'Sullivan D, Christie R (2013) Application of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact. J Clin Pharm Ther 38:360-372
20. Hamilton H, Gallagher P, Ryan C, Byrne S, O'Mahony D (2011) Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med 171:1013-1019
21. Gallagher P, O'Mahony D (2008) STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing 37:673-679
22. Cahir C, Bennett K, Teljeur C, Fahey T (2014) Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients. Br J Clin Pharmacol 77:201-210
23. The European Observatory on Health Systems and Policies (2008) Managing chronic conditions. Experience in eight countries
24. Hakkarainen KM, Gyllensten H, Jonsson AK, Andersson Sundell K, Petzold M, Hagg S (2014) Prevalence, nature and potential preventability of adverse drug events - a population-based medical record study of 4970 adults. Br J Clin Pharmacol 78:170-183
25. Ludvigsson JF, Otterblad-Olausson P, Pettersson BU, Ekbom A (2009) The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. Eur J Epidemiol 24:659-667
26. Wettermark B, Hammar N, Fored CM, Leimanis A, Otterblad Olausson P, Bergman U, Persson I, Sundstrom A, Westerholm B, Rosen M (2007) The new Swedish Prescribed Drug Register - opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 16:726-735
27. Wirehn AB, Karlsson HM, Carstensen JM (2007) Estimating disease prevalence using a population-based administrative healthcare database. Scand J Public Health 35:424-431
28. World Health Organization (1972) International drug monitoring: the role of national centres
29. Morimoto T, Gandhi TK, Seger AC, Hsieh TC, Bates DW (2004) Adverse drug events and medication errors: detection and classification methods. Qual Saf Health Care 13:306-314
30. Bottiger Y, Laine K, Andersson ML, Korhonen T, Molin B, Ovesjo ML, Tirkkonen T, Rane A, Gustafsson LL, Eiermann B (2009) SFINX-a drug-drug interaction database designed for clinical decision support systems. Eur J Clin Pharmacol 65:627-633
31. Howard RL, Avery AJ, Howard PD, Partridge M (2003) Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study. Qual Saf Health Care 12:280-285
32. Edwards IR, Aronson JK (2000) Adverse drug reactions: definitions, diagnosis, and management. Lancet 356:1255-1259
33. The National Board of Health and Welfare Diagnosis. Related groups [In Swedish]. http://www.socialstyrelsen.se/klassificeringochkoder/norddrg. Accessed 29 June 2015
34. Medical Dictionary for Regulatory Activities (2011) Introductory guide MedDRA version 14.0, document MSSO-DI-6003-14.0.0, Medical Dictionary for Regulatory Activities. Geneva
35. Belfrage B, Koldestam A, Sjoberg C, Wallerstedt SM (2014) Prevalence of suboptimal drug treatment in patients with and without multidose drug dispensing - a cross-sectional study. Eur J Clin Pharmacol 70:867-872
36. O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44:213-218
37. Conejos Miquel MD, Sánchez Cuervo M, Delgado Silveira E, Sevilla Machuca I, González-Blazquez S, Montero Errasquin B, Cruz-Jentoft AJ (2010) Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med 1:9-14
38. Ryan C, O'Mahony D, Kennedy J, Weedle P, Byrne S (2009) Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol 68:936-947
39. Garcia-Gollarte F, Baleriola-Julvez J, Ferrero-Lopez I, Cruz-Jentoft AJ (2012) Inappropriate drug prescription at nursing home admission. J Am Med Dir Assoc 13:83.e9-83.15
40. Gallagher P, Lang PO, Cherubini A, Topinkova E, Cruz-Jentoft A, Montero Errasquin B, Madlova P, Gasperini B, Baeyens H, Baeyens JP, Michel JP, O'Mahony D (2011) Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol 67:1175-1188
41. Fialova D, Onder G (2009) Medication errors in elderly people: contributing factors and future perspectives. Br J Clin Pharmacol 67:641-645
42. European Commission (2012) Europeans of retirement age: chronic diseases and economic activity http://ec.europa.eu/health/major-chronic-diseases/docs/rivm-report-retirement-en.pdf. Accessed 09 April 2015
43. Association of the European Self-Medication Industry (2015) http://www.aesgp.eu/facts-figures/otc-ingredients/. Accessed 26 June 2015
44. Deandrea S, Lucenteforte E, Bravi F, Foschi R, La Vecchia C, Negri E (2010) Risk factors for falls in community-dwelling older people: a systematic review and meta-analysis. Epidemiology 21:658-668
45. Weingart SN, Gandhi TK, Seger AC, Seger DL, Borus J, Burdick E, Leape LL, Bates DW (2005) Patient-reported medication symptoms in primary care. Arch Intern Med 165:234-240
46. Pit SW, Byles JE, Henry DA, Holt L, Hansen V, Bowman DA (2007) A Quality Use of Medicines program for general practitioners and older people: a cluster randomised controlled trial. Med J Aust 187:23-30
47. De Smet PA, Dautzenberg M (2004) Repeat prescribing: scale, problems and quality management in ambulatory care patients. Drugs 64:1779-1800
48. Klarin I, Wimo A, Fastbom J (2005) The association of inappropriate drug use with hospitalisation and mortality: a population-based study of the very old. Drugs Aging 22:69-82
49. Rochon PA, Gurwitz JH (1997) Optimising drug treatment for elderly people: the prescribing cascade. BMJ 315:1096-1099
50. The Committee for Collaboration Between Östergötland Region and Municipalities in Östergötland (2011) Elderly report [In Swedish]
51. European Commission (2014) Development and clinical trials of a new software engine for the assessment and optimization of drug and non-drug therapy in older persons (SENATOR). http://ec.europa.eu/research/health/medical-research/human-development-and-ageing/projects/senator-en.html. Accessed 26/06/2015
52. Schmiedl S, Rottenkolber M, Hasford J, Rottenkolber D, Farker K, Drewelow B, Hippius M, Salje K, Thurmann P (2014) Self-medication with over-the-counter and prescribed drugs causing adverse-drug-reaction-related hospital admissions: results of a prospective, long-term multi-centre study. Drug Saf 37:225-235
53. Steinman MA, Handler SM, Gurwitz JH, Schiff GD, Covinsky KE (2011) Beyond the prescription: medication monitoring and adverse drug events in older adults. J Am Geriatr Soc 59:1513-1520
54. Chu HY, Chen CC, Cheng SH (2012) Continuity of care, potentially inappropriate medication, and health care outcomes among the elderly: evidence from a longitudinal analysis in Taiwan. Med Care 50:1002-1009