Systemic Determinants

Ocular Blood Flow

Volumn , Issue , 2012, Pages 173-210

  Lovasik, John V ^a   Kergoat, Hélène ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84946838254     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-69469-4_10     Document Type: Chapter

References (99)

1. Kiel JW (1999) Modulation of choroidal autoregulation in the rabbit. Exp Eye Res 69:413–429
2. Fryczkowski AW (1994) Anatomical and functional choroidal lobuli. Int Ophthalmol 18:131–141
3. Lovasik JV, Kothe AC, Kergoat H (1993) A comparison of non-invasive methods to derive the mean central retinal artery pressure in man. Optom Vis Sci 70:1005–1011
4. Guyton AC, Hall JE (1996) Overview of the circulation: medical physics of pressure, flow, and resistance. In: Textbook of medical physiology. WB Saunders, Philadelphia
5. Al Suwaidi J, Higano ST, Holmes DR Jr et al (2001) Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography. Mayo Clin Proc 76:813–822
6. Menkes MS, Matthews KA, Krantz DS et al (1989) Cardiovascular reactivity to the cold pressor test as a predictor of hypertension. Hypertension 14: 524–530
7. Mizushima T, Tajima F, Nakamura T et al (1998) Muscle sympathetic nerve activity during cold pressor test in patients with cerebral vascular accident. Stroke 29:607–612
8. Lovasik JV, Kergoat H, Riva CE et al (2003) Choroidal blood flow during exercise-induced changes in the ocular perfusion pressure. Invest Ophthalmol Vis Sci 44:2126–2132
9. Riva CE, Titze P, Hero M et al (1997) Choroidal blood flow during isometric exercises. Invest Ophthalmol Vis Sci 38:2338–2343
10. Polska E, Simader C, Weigert G et al (2007) Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure. Invest Ophthalmol Vis Sci 48:3768–3774
11. Lovasik JV, Kergoat H, Gauthier C, Dion I (2009) Regulation of choroidal blood flow fails during cold stimulation. Optom Vis Sci 86:E-abstract 85985
12. Marinier JA, Kergoat H, Lovasik JV (2000) Increased foveal-choroidal blood flow in man during bilateral cold pressor testing. Optom Vis Sci Suppl 77:231
13. Lovasik JV, Kergoat H, Greendale C et al (2003) Changes in retinal vessel diameter during a cold pressor test. Optom Vis Sci Suppl 80
14. Forcier P, Kergoat H, Lovasik JV (1998) Macular hemodynamic responses to short-term acute exercise in humans. Vision Res 38:181–186
15. Kergoat H, Lovasik JV (1995) Response of parapapillary retinal vessels to exercise. Optom Vis Sci 72:249–257
16. Pournaras CJ, Rungger-Brändle E, Riva CE et al (2008) Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27:284–330
17. Maeda S, Miyauchi T, Kakiyama T et al (2001) Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 69:1005–1016
18. Lovasik JV, Kergoat H, Racine N, et al (2007) Neurovascular coupling in long-term joggers versus healthy non-joggers. Invest Ophthalmol Vis Sci 49:E-Abstract 2273
19. Porth CJ, Bamrah VS, Tristani FE et al (1984) The Valsalva maneuver: mechanisms and clinical implications. Heart Lung 13:507–518
20. Lovasik JV, Kergoat H, Riva CE, et al (2002) Correlation between the intra-thoracic pressure and choroidal blood flow. Invest Ophthalmol Vis Sci 49:E-Abstract 3315
21. Benowitz NL (2003) Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment. Prog Cardiovasc Dis 46:91–111
22. Rojanapongpun P, Drance SM (1993) The effects of nicotine on the blood flow of the ophthalmic artery and the finger circulation. Graefe’s Arch Ophthalmol 231:371–374
23. Kaiser HJ, Schoetzau A, Flammer J (1997) Blood flow velocity in the extraocular vessels in chronic smokers. Br J Ophthalmol 81:133–135
24. Steigerwalt RD Jr, Laurora G, Incandela L et al (2000) Ocular and orbital blood flow in cigarette smokers. Retina 20:394–397
25. Lafleur J, Lovasik JV (2000) Nicotine modifies reactivity of foveal choroidal blood flow. Optom Vis Sci Suppl 77:155
26. Balbini APS, Montovani JC (2005) Methods for smoking cessation and treatment of nicotine dependence. Rev Bras Otorrinolaringol 6:820–826
27. Benowitz NL (2008) Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction. Clin Pharmacol Ther 83:531–541
28. Delcourt C, Diaz JL, Ponton-Sanchez A et al (1998) Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l’Age. Arch Ophthalmol 116:1031–1035
29. Lovasik JV, Kothe AC, Spafford MM (1987) Vascular and neural changes during body inversion: preliminary findings. Can J Optom 49:133–140
30. Kergoat H, Lovasik JV (1990) The effects of altered retinal vascular perfusion pressure on the white flash scotopic ERG and oscillatory potentials in man. Electroencephalogr Clin Neurophysiol 75: 306–322
31. Lovasik JV (1999) Assessment of the vascular autoregulatory properties in the human choroid with two measurement systems. Optom Vis Sci Suppl 76:246
32. Kergoat H, Lovasik JV (2005) Seven-degree headdown tilt reduces choroidal pulsatile ocular blood flow. Aviat Space Environ Med 76:930–934
33. Lovasik JV, Kergoat H (1994) Gravity induced homeostatic reactions in the macular and choroidal vasculature of the human eye. Aviat Space Environ Med 65:1010–1014
34. Gee W (1985) Ocular pneumoplethysmography. Surv Ophthalmol 29:276–292
35. Lovasik JV (2004) Choroidal dynamics during rapid vs slow changes in ocular perfusion. Optom Vis Sci Suppl 81:167
36. Lovasik JV, Gagnon M, Kergoat H (1994) Correlation of the chromaticity of the human ocular fundus with changes in the intraocular pressure, choroidal blood flow, and visual neural function. Surv Ophthalmol 38:S35–S51
37. Lovasik JV, Kergoat H (1996) Laser Doppler measurements of blood flow in the optic nerve head during cardiac shunting of blood. Optom Vis Sci Suppl 73:77
38. Koelle JS, Riva CE, Petrig BL et al (1993) Depth of tissue sampling in the optic nerve head using laser Doppler flowmetry. Laser Med Sci 8:49–54
39. Silverman SE, Trick GL, Hart WM Jr (1990) Motion perception is abnormal in primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 31:722–729
40. Fitzgerald ME, Vana BA, Reiner A (1990) Control of choroidal blood flow by the nucleus of Edinger- Westphal in pigeons: a laser Doppler study. Invest Ophthalmol Vis Sci 31:2483–2492
41. Kergoat H, Lovasik JV (1994) Unilateral ocular vascular stress in man and retinal responsivity in the contralateral eye. Ophthalmic Physiol Opt 14:401–407
42. Lovasik JV, Kergoat H, Gagnon M (2005) Experimentally reduced perfusion of one eye impairs retinal function in both eyes. Optom Vis Sci 82:850–857
43. Fitzgerald ME, Gamlin PD, Zagvazdin Y et al (1996) Central neural circuits for the light-mediated reflexive control of choroidal blood flow in the pigeon eye: a laser Doppler study. Vis Neurosci 13:655–669
44. Lovasik JV, Kothe AC (1989) Neural effects of transiently raised intraocular pressure: the scotopic and photopic flash electroretinogram. Clin Vis Sci 4:313–321
45. Linsenmeier RA (1986) Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 88:521–542
46. Kothe AC, Lovasik JV (1988) Neural effects of body inversion: photopic oscillatory potentials. Curr Eye Res 7:1221–1229
47. Kiss B, Polska E, Dorner G et al (2002) Retinal blood flow during hyperoxia in human revisited: concerted results using different measurement techniques. Microvasc Res 64:75–85
48. Gilmore ED, Hudson C, Nrusimhadevara RK et al (2007) Retinal arteriolar diameter, blood velocity, and blood flow response to an isocapnic hyperoxic provocation in early sight-threatening diabetic retinopathy. Invest Ophthalmol Vis Sci 48:1744–1750
49. Jean-Louis S, Lovasik JV, Kergoat H (2005) Systemic hyperoxia and retinal vasomotor responses. Invest Ophthalmol Vis Sci 46:1714–1720
50. Kergoat H, Lovasik JV, Justino L (2001) Effects of hyperoxia on the blood flow and neural function of the inner retina. Optom Vis Sci Suppl 78:99
51. Kergoat H, Faucher C (1999) Effects of oxygen and carbogen breathing on choroidal hemodynamics in humans. Invest Ophthalmol Vis Sci 40:2906–2911
52. Kergoat H, Marinier JA, Lovasik JV (2005) Effects of transient mild systemic hypoxia on the pulsatile choroidal blood flow in healthy young human adults. Curr Eye Res 30:465–470
53. Geiser MH, Riva CE, Dorner GT et al (2000) Response of choroidal blood flow in the foveal region to hyperoxia and hyperoxia-hypercapnia. Curr Eye Res 21:669–676
54. Riva CE, Cranstoun SD, Grunwald JE et al (1994) Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci 35:4273–4281
55. 2 on ocular fundus pulsations. Exp Eye Res 63:351–355
56. Schmetterer L, Wolzt M, Lexer F et al (1995) The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young men. Exp Eye Res 61:685–690
57. 2 responsiveness of cerebral and ocular circulation in humans. Am J Physiol 273: R2005–R2012
58. Trokel S (1965) Effect of respirator gases upon choroidal hemodynamics. Arch Ophthalmol 73:838–842
59. Friedman E, Chandra SR (1972) Choroidal blood flow III. Effects of oxygen and carbon dioxide. Arch Ophthalmol 87:70–71
60. Alm A, Bill A (1972) The oxygen supply to the retina. II. Effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. A study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Acta Physiol Scand 84:306–319
61. 2 in rat measured with a modified microsphere technique. Exp Eye Res 86:908–913
62. Fallon TJ, Maxwell D, Kohner M (1985) Retinal vascular autoregulation in conditions of hyperoxia and hypoxia using the blue field entoptic phenomenon. Ophthalmology 92:701–705
63. 2. Br J Ophthalmol 81:360–364
64. Kergoat H, Tinjust D (2004) Neuroretinal function during systemic hyperoxia and hypercapnia in humans. Optom Vis Sci 81:214–220
65. Faucher C, Kergoat H (2002) Modulation of the scotopic electroretinogram and oscillatory potentials with systemic hyperoxia and hypercapnia in humans. Curr Eye Res 24:376–386
66. Tinjust D, Kergoat H, Lovasik JV (2002) Investigation of neuroretinal function during mild systemic hypoxia in man. Aviat Space Environ Med 73:1189–1194
67. 2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia. Exp Eye Res 49:347–360
68. Kergoat H, Hérard MÈ, Lemay M (2006) RGC sensitivity to mild systemic hypoxia. Invest Ophthalmol Vis Sci 47:5423–5427
69. Grunwald JE, Hariprasad SM, DuPont J et al (1998) Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci 39: 385–390
70. Metelitsina TI, Grunwald JE, DuPont JC et al (2008) Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 49:358–363
71. Kiryu J, Asrani S, Shahidi M et al (1995) Local response of the primate retinal microcirculation to increased metabolic demand induced by flicker. Invest Ophthalmol Vis Sci 36:1240–1246
72. McArdle WD, Katch FI, Katch VL (1996) Functional capacity of the cardiovascular system. In: Exercise physiology: energy, nutrition and human performance. Williams & Wilkins, Baltimore
73. Østerberg G (1935) Topography of the layer of rods and cones in the human retina. Acta Ophthalmol Suppl 6:1–103
74. Ahnelt PK (1998) The photoreceptor mosaic. Eye 12:531–540
75. Linsenmeier RA, Padnick-Silver L (2000) Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci 41:3117–3123
76. Kergoat H, Lovasik JV, Bitton E (2002) Reduction in choroidal blood flow in the foveal and perifoveal area during dark adaptation. Invest Ophthalmol Vis Sci 49:E-Abstract 3300
77. Feke GT, Zuckerman R, Green GJ et al (1983) Response of human retinal blood flow to light and dark. Invest Ophthalmol Vis Sci 24:136–141
78. Riva CE, Grunwald JE, Petrig BL (1983) Reactivity of the human retinal circulation to darkness: a laser Doppler velocimetry study. Invest Ophthalmol Vis Sci 24:737–740
79. Formaz F, Riva CE, Geiser M (1997) Diffuse luminance flicker increases retinal vessel diameter in humans. Curr Eye Res 16:1252–1257
80. Falsini B, Riva CE, Logean E (2002) Flicker-evoked changes in human optic nerve blood flow: relationship with retinal neural activity. Invest Ophthalmol Vis Sci 43:2309–2316
81. Michelson G, Patzelt A, Harazny J (2002) Flickering light increases retinal blood flow. Retina 22: 336–343
82. Longo A, Geiser M, Riva CE (2000) Effect of light on choroidal blood flow in the fovea centralis. Klin Monatsbl Augenheilkd 216:311–312
83. Garhofer G, Huemer KH, Zawinka C et al (2002) Influence of diffuse luminance flicker on choroidal and optic nerve head blood flow. Curr Eye Res 24:109–113
84. Lovasik JV, Kergoat H, Wajszilber MA (2005) Blue flicker modifies the subfoveal choroidal blood flow in the human eye. Am J Physiol Heart Circ Physiol 289:H683–H691, Epub 2005 Apr 1
85. Ibrahim YW, Bots ML, Mulder PG et al (1998) Number of perifoveal vessels in aging, hypertension, and atherosclerosis: the Rotterdam study. Invest Ophthalmol Vis Sci 39:1049–1053
86. Stanton AV, Wasan B, Cerutti A et al (1995) Vascular network changes in the retina with age and hypertension. J Hypertens 13:1724–1728
87. Ramrattan RS, van der Schaft TL, Mooy CM et al (1994) Morphometric analysis of Bruch’s membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol Vis Sci 35:2857–2864
88. Nuzzi R, Finazzo C, Grignolo FM (1996) Changes in adrenergic innervation of the choroid during aging. J Fr Ophtalmol 19:89–96
89. Killingsworth MC (1987) Age-related components of Bruch’s membrane. Graefes Arch Clin Exp Ophthalmol 225:406–412
90. Curcio CA, Leigh Millican C, Bailey T et al (2001) Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci 42:265–274
91. Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch’s membrane. Invest Ophthalmol Vis Sci 36:1290–1297
92. Starita C, Hussain AA, Patmore A et al (1997) Localization of the site of major resistance to fluid transport in Bruch’s membrane. Invest Ophthalmol Vis Sci 38:762–767
93. Polak K, Schmetterer L, Riva CE (2002) Influence of flicker frequency on flicker-induced changes of retinal vessel diameter. Invest Ophthalmol Vis Sci 43: 2721–2726
94. Nagel E, Vilser W (2004) Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study. Br J Ophthalmol 88:54–56
95. Lovasik JV, Kergoat H, Boutin T, et al (2008) Retinal arterial constriction with aging may modulate vascular perfusion of the eye. Invest Ophthalmol Vis Sci 49:E-Abstract 2090
96. Kergoat H, Kergoat MJ, Justino L (2001) Age related changes in the flash electroretinogram and oscillatory potentials in individuals 75 years of age and older. J Am Geriatr Soc 49:1–6
97. Justino L, Kergoat H, Kergoat MJ (2001) Changes in the retinocortical evoked potentials in subjects 75 years of age and older. Clin Neurophysiol 112:1343–1348
98. Lovasik JV, Kergoat MJ, Justino L et al (2003) Neuroretinal basis of visual impairment in the very elderly. Graefe’s Arch Clin Exp Ophthalmol 241:48–55
99. Kergoat H, Kergoat MJ, Justino L et al (2001) Agerelated topographical changes in the normal human optic nerve head measured by scanning laser tomography. Optom Vis Sci 78:431–435