Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase

Journal of General Virology

Volumn 96, Issue 11, 2015, Pages 3236-3242

  Domingues, Patricia ^a,b   Bamford, Connor G G ^a   Boutell, Chris ^a   McLauchlan, John ^a  

^a MRC UNIVERSITY OF GLASGOW CENTRE FOR VIRUS RESEARCH   (United Kingdom)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; HERC5; LIGASE; PROTEIN; PROTEIN ISG15; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS RNA; CYTOKINE; HERC5 PROTEIN, HUMAN; ISG15 PROTEIN, HUMAN; SIGNAL PEPTIDE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONJUGATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; GENE EXPRESSION; GENE INACTIVATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA REPLICATION; U2OS CELL LINE; VIRUS GENOME; VIRUS REPLICATION; GENETICS; HEPACIVIRUS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; VIROLOGY;

CYTOKINES; HEPACIVIRUS; HEPATITIS C; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; RNA, VIRAL; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS; VIRUS REPLICATION;

EID: 84946820021     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/jgv.0.000283     Document Type: Article

References (26)

1. Abe, H., Hayes, C. N., Ochi, H., Tsuge, M., Miki, D., Hiraga, N., Imamura, M., Takahashi, S., Kubo, M. & other authors (2011). Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state. J Med Virol 83, 1597-1607.
2. Bensadoun, P., Rodriguez, C., Soulier, A., Higgs, M., Chevaliez, S. & Pawlotsky, J. M. (2011). Genetic background of hepatocyte cell lines: are in vitro hepatitis C virus research data reliable? Hepatology 54, 748.
3. Bogunovic, D., Byun, M., Durfee, L. A., Abhyankar, A., Sanal, O., Mansouri, D., Salem, S., Radovanovic, I., Grant, A. V. & other authors (2012). Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science 337, 1684-1688.
4. Broering, R., Zhang, X., Kottilil, S., Trippler, M., Jiang, M., Lu, M., Gerken, G. & Schlaak, J. F. (2010). The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response. Gut 59, 1111-1119.
5. Campbell, J. A. & Lenschow, D. J. (2013). Emerging roles for immunomodulatory functions of free ISG15. J Interferon Cytokine Res 33, 728-738.
6. Chen, L., Sun, J., Meng, L., Heathcote, J., Edwards, A. M. & McGilvray, I. D. (2010). ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment. J Gen Virol 91, 382-388.
7. Chua, P. K., McCown, M. F., Rajyaguru, S., Kular, S., Varma, R., Symons, J., Chiu, S. S., Cammack, N. & Nájera, I. (2009). Modulation of alpha interferon anti-hepatitis C virus activity by ISG15. J Gen Virol 90, 2929-2939.
8. Everett, R. D., Rechter, S., Papior, P., Tavalai, N., Stamminger, T. & Orr, A. (2006). PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. J Virol 80, 7995-8005.
9. Ge, D., Fellay, J., Thompson, A. J., Simon, J. S., Shianna, K. V., Urban, T. J., Heinzen, E. L., Qiu, P., Bertelsen, A. H. & other authors (2009). Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461, 399-401.
10. Hoffmann, T. W., Delfosse, F., Helle, F., François, C., Duverlie, G. & Castelain, S. (2014). The expression of HCV-associated host factors is dependent on the hepatoma cell line used in HCV studies. Arch Virol 159, 527-534.
11. Jeon, Y. J., Yoo, H. M. & Chung, C. H. (2010). ISG15 and immune diseases. Biochim Biophys Acta 1802, 485-496.
12. Jones, D. M., Domingues, P., Targett-Adams, P. & McLauchlan, J. (2010). Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication. J Gen Virol 91, 2238-2248.
13. Kim, M. J. & Yoo, J. Y. (2010). Inhibition of hepatitis C virus replication by IFN-mediated ISGylation of HCV-NS5A. J Immunol 185, 4311-4318.
14. Loeb, K. R. & Haas, A. L. (1992). The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. J Biol Chem 267, 7806-7813.
15. MacQuillan, G. C., Mamotte, C., Reed, W. D., Jeffrey, G. P. & Allan, J. E. (2003). Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection. J Med Virol 70, 219-227.
16. Malakhov, M. P., Malakhova, O. A., Kim, K. I., Ritchie, K. J. & Zhang, D. E. (2002). UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem 277, 9976-9981.
17. Mitsui, K., Nakanishi, M., Ohtsuka, S., Norwood, T. H., Okabayashi, K., Miyamoto, C., Tanaka, K., Yoshimura, A. & Ohtsubo, M. (1999). A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. Biochem Biophys Res Commun 266, 115-122.
18. Potter, J. L., Narasimhan, J., Mende-Mueller, L. & Haas, A. L. (1999). Precursor processing of pro-ISG15/UCRP, an interferon-induced ubiquitin-like protein. J Biol Chem 274, 25061-25068.
19. Ran, F. A., Hsu, P. D., Lin, C. Y., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S. & other authors (2013). Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389.
20. Robinson, M. W., Aranday-Cortes, E., Gatherer, D., Swann, R., Liefhebber, J. M., Filipe, A. D., Sigruener, A., Barclay, S. T., Mills, P. R. & other authors (2015). Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection. Liver Int.
21. Shen, B., Zhang, W., Zhang, J., Zhou, J., Wang, J., Chen, L., Wang, L., Hodgkins, A., Iyer, V. & other authors (2014). Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods 11, 399-402.
22. Suppiah, V., Moldovan, M., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M. L., Bassendine, M., Spengler, U., Dore, G. J. & other authors (2009). IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nat Genet 41, 1100-1104.
23. Tanaka, Y., Nishida, N., Sugiyama, M., Kurosaki, M., Matsuura, K., Sakamoto, N., Nakagawa, M., Korenaga, M., Hino, K. & other authors (2009). Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C. Nat Genet 41, 1105-1109.
24. Targett-Adams, P. & McLauchlan, J. (2005). Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic replicon. J Gen Virol 86, 3075-3080.
25. Werneke, S. W., Schilte, C., Rohatgi, A., Monte, K. J., Michault, A., Arenzana-Seisdedos, F., Vanlandingham, D. L., Higgs, S., Fontanet, A. & other authors (2011). ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog 7, e1002322.
26. Zhao, C., Collins, M. N., Hsiang, T. Y. & Krug, R. M. (2013). Interferoninduced ISG15 pathway: an ongoing virus-host battle. Trends Microbiol 21, 181-186.