A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Advanced Materials

Volumn 27, Issue 42, 2015, Pages 6637-6643

  Lee, Wonhwa ^a   Seo, Junyoung ^b   Kwak, Soyoung ^a   Park, Eun Ji ^a   Na, Dong Hee ^a   Kim, Soyoun ^b   Lee, You Mie ^a   Kim, In San ^c,d   Bae, Jong Sup ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Korea University   (South Korea)

Author keywords

ferritin; nanoparticles; PC gla; sepsis; TRAP

Indexed keywords

ENZYMES; GLYCOPROTEINS; NANOPARTICLES; PEPTIDES;

CARBOXYGLUTAMIC ACID; FERRITIN; FUNCTIONAL PROTEINS; NANOCAGES; ORGAN INJURIES; SEPSIS; THROMBIN RECEPTORS; TRAP;

PROTEINS;

4 CARBOXYGLUTAMIC ACID; ANTIINFLAMMATORY AGENT; COLLAGENASE; FERRITIN; LIPOPOLYSACCHARIDE; NANOMATERIAL; PEPTIDE FRAGMENT; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN RECEPTOR;

AGONISTS; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FETUS BLOOD; HUMAN; HUMAN EMBRYONIC STEM CELL; LEUKOCYTE; MALE; METABOLISM; MORTALITY; PHYSIOLOGY; SEPSIS;

1-CARBOXYGLUTAMIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS; COLLAGENASES; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FERRITINS; FETAL BLOOD; HUMAN EMBRYONIC STEM CELLS; HUMANS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED C57BL; NANOSTRUCTURES; PEPTIDE FRAGMENTS; PROTEIN C; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; SEPSIS;

EID: 84946763409     PISSN: 09359648     EISSN: 15214095     Source Type: Journal    
DOI: 10.1002/adma.201503093     Document Type: Article

References (41)

1. L. Yildirimer, N. T. Thanh, M. Loizidou, A. M. Seifalian, Nano Today 2011, 6, 585.
2. W. H. De Jong, P. J. Borm, Int. J. Nanomed. 2008, 3, 133.
3. T. Douglas, M. Young, Science 2006, 312, 873.
4. M. Uchida, M. T. Klem, M. Allen, P. Suci, M. Flenniken, E. Gillitzer, Z. Varpness, L. O. Liepold, M. Young, T. Douglas, Adv. Mater. 2007, 19, 1025.
5. J. M. Hooker, A. Datta, M. Botta, K. N. Raymond, M. B. Francis, Nano Lett. 2007, 7, 2207.
6. J. O. Jeon, S. Kim, E. Choi, K. Shin, K. Cha, I. S. So, S. J. Kim, E. Jun, D. Kim, H. J. Ahn, B. H. Lee, S. H. Lee, I. S. Kim, ACS Nano 2013, 7, 7462.
7. M. Uchida, M. L. Flenniken, M. Allen, D. A. Willits, B. E. Crowley, S. Brumfield, A. F. Willis, L. Jackiw, M. Jutila, M. J. Young, T. Douglas, J. Am. Chem. Soc. 2006, 128, 16626.
8. L. O. Liepold, M. J. Abedin, E. D. Buckhouse, J. A. Frank, M. J. Young, T. Douglas, Nano Lett. 2009, 9, 4520.
9. J. A. Russell, New England J. Med. 2006, 355, 1699.
10. J. C. A. Ballester, F. Ballester, A. G. Sanchez, A. A. Quilis, E. C. Rubio, C. P. Otero, Infect. Control. Hosp. Epidemiol. 2008, 29, 630.
11. D. C. Angus, R. S. Wax, Crit. Care Med. 2001, 29, S109.
12. M. A. Matthay, New England J. Med. 2001, 344, 759.
13. L. O. Mosnier, B. V. Zlokovic, J. H. Griffin, Blood 2007, 109, 3161.
14. G. R. Bernard, J. L. Vincent, P. F. Laterre, S. P. LaRosa, J. F. Dhainaut, A. Lopez-Rodriguez, J. S. Steingrub, G. E. Garber, J. D. Helterbrand, E. W. Ely, C. J. Fisher Jr., New England J. Med. 2001, 344, 699.
15. J. Thachil, C. H. Toh, M. Levi, H. G. Watson, British J. Haematol. 2012, 157, 493.
16. G. R. Bernard, W. L. Macias, D. E. Joyce, M. D. Williams, J. Bailey, J. L. Vincent, Crit. Care 2003, 7, 155.
17. T. Mather, V. Oganessyan, P. Hof, R. Huber, S. Foundling, C. Esmon, W. Bode, EMBO J. 1996, 15, 6822.
18. M. J. Heeb, A. Gruber, J. H. Griffin, J. Biol. Chem. 1991, 266, 17606.
19. C. Feistritzer, R. A. Schuepbach, L. O. Mosnier, L. A. Bush, E. Di Cera, J. H. Griffin, M. Riewald, J. Biol. Chem. 2006, 281, 20077.
20. C. Feistritzer, M. Riewald, Blood 2005, 105, 3178.
21. J. S. Bae, L. Yang, C. Manithody, A. R. Rezaie, Blood 2007, 110, 3909.
22. J. S. Bae, A. R. Rezaie, Thromb. Haemost. 2008, 100, 101.
23. H. Kim, G. Koh, Biochem. Biophys. Res. Commun. 2000, 269, 401.
24. P. Yazdan-Ashoori, P. Liaw, L. Toltl, B. Webb, G. Kilmer, D. E. Carter, D. D. Fraser, J. Crit. Care 2011, 26, 556.
25. J. A. Buras, B. Holzmann, M. Sitkovsky, Nat. Rev. Drug Discovery 2005, 4, 854.
26. L. M. Regan, D. J. Stearns-Kurosawa, S. Kurosawa, J. Mollica, K. Fukudome, C. T. Esmon, J. Biol. Chem. 1996, 271, 17499.
27. M. E. Astiz, E. C. Rackow, Lancet 1998, 351, 1501.
28. P. Stenvinkel, M. Ketteler, R. J. Johnson, B. Lindholm, R. Pecoits-Filho, M. Riella, O. Heimburger, T. Cederholm, M. Girndt, Kidney Int. 2005, 67, 1216.
29. N. C. Riedemann, T. A. Neff, R. F. Guo, K. D. Bernacki, I. J. Laudes, J. V. Sarma, J. D. Lambris, P. A. Ward, J. Immunol. 2003, 170, 503.
30. E. Abraham, M. Singer, Crit. Care Med. 2007, 35, 2408.
31. S. M. Weis, Curr. Opin. Hematol. 2008, 15, 243.
32. P. S. Frenette, D. D. Wagner, New England J. Med. 1996, 334, 1526.
33. S. M. Albelda, C. W. Smith, P. A. Ward, FASEB J. 1994, 8, 504.
34. D. B. Kell, E. Pretorius, Metallomics 2014, 6, 748.
35. L. A. Cohen, L. Gutierrez, A. Weiss, Y. Leichtmann-Bardoogo, D. L. Zhang, D. R. Crooks, R. Sougrat, A. Morgenstern, B. Galy, M. W. Hentze, F. J. Lazaro, T. A. Rouault, E. G. Meyron-Holtz, Blood 2010, 116, 1574.
36. C. E. Alford, T. E. King Jr., P. A. Campbell, J. Exp. Med. 1991, 174, 459.
37. Y. Wang, W. Wu, Drug Delivery 2006, 13, 189.
38. N. G. Bastus, E. Sanchez-Tillo, S. Pujals, C. Farrera, C. Lopez, E. Giralt, A. Celada, J. Lloberas, V. Puntes, ACS Nano 2009, 3, 1335.
39. L. Galligan, W. Livingstone, Y. Volkov, K. Hokamp, C. Murphy, M. Lawler, K. Fukudome, O. Smith, British J. Haematol. 2001, 115, 408.
40. H. P. H. Liang, E. J. Kerschen, I. Hernandez, S. Basu, M. Zogg, F. Botros, S. Jia, M. J. Hessner, J. H. Griffin, W. Ruf, H. Weiler, Blood 2015, 125, 2845.
41. R. Colognato, J. R. Slupsky, M. Jendrach, L. Burysek, T. Syrovets, T. Simmet, Blood 2003, 102, 2645.