Chronic lung infection by Pseudomonas aeruginosa biofilm is cured by L-Methionine in combination with antibiotic therapy

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Gnanadhas, Divya Prakash ^a,b   Elango, Monalisha ^a   Datey, Akshay ^a   Chakravortty, Dipshikha ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; METHIONINE;

ANIMAL; BAGG ALBINO MOUSE; BIOFILM; COMMUNICABLE DISEASES; DRUG EFFECTS; LUNG; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOUSE; PROCEDURES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; COMMUNICABLE DISEASES; LUNG; METHIONINE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS;

EID: 84946762181     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16043     Document Type: Article

References (57)

1. Costerton, J. W., Stewart, P. S. & Greenberg, E. P. Bacterial Biofilms: A Common Cause of Persistent Infections. Science 284, 1318-1322 (1999)
2. Lam, J., Chan, R., Lam, K. & Costerton, J. W. Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis. Infect Immun 28, 546-556 (1980)
3. Singh, P. K. et al. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407, 762-764 (2000)
4. Stoodley, P., Sauer, K., Davies, D. G. & Costerton, J. W. Biofilms as complex differentiated communities. Annual Review of Microbiology 56, 187-209 (2002)
5. Allesen-Holm, M. et al. A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms. Mol Microbiol 59, 1114-1128 (2006)
6. Branda, S. S., Vik, S., Friedman, L. & Kolter, R. Biofilms: the matrix revisited. Trends Microbiol 13, 20-26 (2005)
7. Matsukawa, M. & Greenberg, E. P. Putative exopolysaccharide synthesis genes influence Pseudomonas aeruginosa biofilm development. J Bacteriol 186, 4449-4456 (2004)
8. Whitchurch, C. B., Tolker-Nielsen, T., Ragas, P. C. & Mattick, J. S. Extracellular DNA required for bacterial biofilm formation. Science 295, 1487 (2002)
9. Gloag, E. S. et al. Self-organization of bacterial biofilms is facilitated by extracellular DNA. Proceedings of the National Academy of Sciences 110, 11541-11546 (2013)
10. Okshevsky, M. & Meyer, R. L. The role of extracellular DNA in the establishment, maintenance and perpetuation of bacterial biofilms. Crit Rev Microbiol 0, 1-11 (2013)
11. Das, T., Sharma, P. K., Busscher, H. J., van der Mei, H. C. & Krom, B. P. Role of extracellular DNA in initial bacterial adhesion and surface aggregation. Appl Environ Microbiol 76, 3405-3408 (2010)
12. Liu, H. H. et al. Role of DNA in bacterial aggregation. Curr Microbiol 57, 139-144 (2008)
13. Mulcahy, H., Charron-Mazenod, L. & Lewenza, S. Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms. PLoS Pathog 4, e1000213 (2008)
14. Webb, J. S. et al. Cell death in Pseudomonas aeruginosa biofilm development. J Bacteriol 185, 4585-4592 (2003)
15. Govan, J. R. & Deretic, V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60, 539-574 (1996)
16. Lyczak, J. B., Cannon, C. L. & Pier, G. B. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect 2, 1051-1060 (2000)
17. Garo, E. et al. Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Antimicrob Agents Chemother 51, 1813-1817 (2007)
18. Lee, J. H., Cho, M. H. & Lee, J. 3-indolylacetonitrile decreases Escherichia coli O157:H7 biofilm formation and Pseudomonas aeruginosa virulence. Environ Microbiol 13, 62-73 (2011)
19. Hentzer, M. et al. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 22, 3803-3815 (2003)
20. Bjarnsholt, T. et al. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology 151, 3873-3880 (2005)
21. Hu, J. F. et al. Bacterial biofilm inhibitors from Diospyros dendo. J Nat Prod 69, 118-120 (2006)
22. Wu, H. et al. Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation. FEMS Immunol Med Microbiol 62, 49-56 (2011)
23. Kolodkin-Gal, I. et al. D-amino acids trigger biofilm disassembly. Science 328, 627-629 (2010)
24. Hochbaum, A. I. et al. Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J Bacteriol 193, 5616-5622 (2011)
25. Brandenburg, K. S. et al. Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrob Agents Chemother 57, 1921-1925 (2013)
26. Tang, L., Schramm, A., Neu, T. R., Revsbech, N. P. & Meyer, R. L. Extracellular DNA in adhesion and biofilm formation of four environmental isolates: a quantitative study. FEMS Microbiology Ecology 86, 394-403 (2013)
27. Mulcahy, H., Charron-Mazenod, L. & Lewenza, S. Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient source. Environmental Microbiology 12, 1621-1629 (2010)
28. Guy Yachdav et al. PredictProtein-an open resource for online prediction of protein structural and functional features. Nucl Acids Res 42, W337-W343 (2014)
29. Conrad, J. C. et al. Flagella and pili-mediated near-surface single-cell motility mechanisms in P. aeruginosa. Biophys J 100, 1608-1616 (2011)
30. OToole, G. A. & Kolter, R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 30, 295-304 (1998)
31. Ruer, S., Stender, S., Filloux, A. & de Bentzmann, S. Assembly of fimbrial structures in Pseudomonas aeruginosa: functionality and specificity of chaperone-usher machineries. J Bacteriol 189, 3547-3555 (2007)
32. Oura, H. et al. Inhibition of Pseudomonas aeruginosa swarming motility through 1-naphthol and other bicyclic compounds bearing hydroxyl groups. Appl Environ Microbiol, doi: 10. 1128/AEM. 04220-14, (2015)
33. Heeckeren, A. et al. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J Clin Invest 100, 2810-2815 (1997)
34. Zottola, E. A. & Sasahara, K. C. Microbial biofilms in the food processing industry-Should they be a concern? International Journal of Food Microbiology 23, 125-148 (1994)
35. van Loosdrecht, M. C., Lyklema, J., Norde, W. & Zehnder, A. J. Influence of interfaces on microbial activity. Microbiological Reviews 54, 75-87 (1990)
36. Flemming, C. A., Palmer, R. J., Arrage, A. A., van der Mei, H. C. & White, D. C. Cell surface physicochemistry alters biofilm development of pseudomonas aeruginosa lipopolysaccharide mutants. Biofouling 13, 213-231 (1998)
37. Busscher, H. J., Bos, R. & van der Mei, H. C. Initial microbial adhesion is a determinant for the strength of biofilm adhesion. FEMS Microbiol Lett 128, 229-234 (1995)
38. Reid, G., Denstedt, J. D., Kang, Y. S., Lam, D. & Nause, C. Microbial adhesion and biofilm formation on ureteral stents in vitro and in vivo. J Urol 148, 1592-1594 (1992)
39. Reid, G. & Busscher, H. J. Importance of surface properties in bacterial adhesion to biomaterials, with particular reference to the urinary tract. International Biodeterioration & Biodegradation 30, 105-122 (1992)
40. Nickel, J. C. et al. Antibiotic resistance of Pseudomonas aeruginosa colonizing a urinary catheter in vitro. Eur J, Clin Microbiol 4, 213-218 (1985)
41. Eckhart, L., Fischer, H., Barken, K. B., Tolker-Nielsen, T. & Tschachler, E. DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus. Br J Dermatol 156, 1342-1345 (2007)
42. Alhede, M., Bjarnsholt, T., Givskov, M. & Alhede, M. Chapter One - Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion. In: Advances in Applied Microbiology (ed^(eds Sima S, Geoffrey MG). Academic Press (2014)
43. Nijland, R., Hall, M. J. & Burgess, J. G. Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase. PLoS ONE 5, e15668 (2010)
44. Thallinger, B., Prasetyo, E. N., Nyanhongo, G. S. & Guebitz, G. M. Antimicrobial enzymes: An emerging strategy to fight microbes and microbial biofilms. Biotechnology Journal 8, 97-109 (2013)
45. Tetz, G. V., Artemenko, N. K. & Tetz, V. V. Effect of DNase and Antibiotics on Biofilm Characteristics. Antimicrobial Agents and Chemotherapy 53, 1204-1209 (2009)
46. Ghavami, S. et al. S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. Journal of Leukocyte Biology 83, 1484-1492 (2008)
47. Banerjee, A., Kunwar, A., Mishra, B. & Priyadarsini, K. I. Concentration dependent antioxidant/pro-oxidant activity of curcumin: Studies from AAPH induced hemolysis of RBCs. Chemico-Biological Interactions 174, 134-139 (2008)
48. Bernier, S. P. & Surette, M. G. Concentration-dependent activity of antibiotics in natural environments. Frontiers in Microbiology 4, 20 (2013)
49. Folkesson, A. et al. Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective. Nat Rev Microbiol 10, 841-851 (2012)
50. Ma, L., Wang, S., Wang, D., Parsek, M. R. & Wozniak, D. J. The roles of biofilm matrix polysaccharide Psl in mucoid Pseudomonas aeruginosa biofilms. FEMS Immunology & Medical Microbiology 65, 377-380 (2012)
51. Fuchs, H. J. et al. Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis. New England Journal of Medicine 331, 637-642 (1994)
52. Bucki, R. et al. Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin. Journal of Cystic Fibrosis, (2015). doi: 10. 1016/j. jcf. 2015. 02. 001
53. Deacon, J. et al. Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: Formulation, characterisation and functionalisation with dornase alfa (DNase). Journal of Controlled Release 198, 55-61 (2015)
54. Holloway, B. W. & Morgan, A. F. Genome organization in Pseudomonas. Annu Rev Microbiol 40, 79-105 (1986)
55. Okajima, Y., Kobayakawa, S., Tsuji, A. & Tochikubo, T. Biofilm Formation by Staphylococcus epidermidis on Intraocular Lens Material. Investigative Ophthalmology & Visual Science 47, 2971-2975 (2006)
56. Nolan, L. M. et al. Extragenic suppressor mutations that restore twitching motility to fimL mutants of Pseudomonas aeruginosa are associated with elevated intracellular cyclic AMP levels. MicrobiologyOpen 1, 490-501 (2012)
57. Odak, E. & Trafny, E. A. Secretion of Proteases by Pseudomonas aeruginosa Biofilms Exposed to Ciprofloxacin. Antimicrobial Agents and Chemotherapy 49, 3281-3288 (2005)