Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction

Experimental Biology and Medicine

Volumn 240, Issue 9, 2015, Pages 1247-1255

  Korkmaz, Sevil ^a   Atmanli, Ayhan ^a   Li, Shiliang ^a   Radovits, Tamás ^b   Hegedűs, Peter ^a,b   Barnucz, Enikő ^a,b   Hirschberg, Kristóf ^a   Loganathan, Sivakkanan ^a   Yoshikawa, Yutaka ^c   Yasui, Hiroyuki ^c   Karck, Matthias ^a   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acetylsalicylic acid; Antioxidant; Cardiac function; Isoproterenol; Myocardial ischemia; Zinc complex of acetylsalicylic acid

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOPRENALINE; MESSENGER RNA; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TROPONIN T; UNCLASSIFIED DRUG; ZINC COMPLEX OF ACETYLSALICYLIC ACID; BIS(ASPIRINATO)ZINC(II); COORDINATION COMPOUND; NONSTEROID ANTIINFLAMMATORY AGENT; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; BLOOD ANALYSIS; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; DRUG MECHANISM; ELECTROCARDIOGRAPHY; GENE EXPRESSION; HEART HEMODYNAMICS; HEART MUSCLE INJURY; HEART RATE; HEART STROKE VOLUME; HISTOPATHOLOGY; INFLAMMATION; LEFT VENTRICULAR CONTRACTILITY INDEX; MYOCARDIAL DISEASE; NONHUMAN; QT INTERVAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; ST SEGMENT ELEVATION; SYSTEMIC VASCULAR RESISTANCE; ULCEROGENESIS; VASCULAR RESISTANCE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; COMPARATIVE STUDY; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; HEART CONTRACTION; HEART INFARCTION; HEMODYNAMICS; MALE; MYOCARDIAL ISCHEMIA; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; COORDINATION COMPLEXES; ELECTROCARDIOGRAPHY; GENE EXPRESSION REGULATION; HEMODYNAMICS; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; RATS; RATS, SPRAGUE-DAWLEY; TROPONIN T; ZINC;

EID: 84946728954     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370215570184     Document Type: Article

References (33)

1. Whellan DJ. Heart failure disease management: implementation and outcomes. Cardiol Rev 2005;13:231–9
2. Sahna E, Deniz E, Bay-Karabulut A, Burma O. Melatonin protects myocardium from ischemia-reperfusion injury in hypertensive rats: role of myeloperoxidase activity. Clin Exp Hypertens 2008;30:673–81
3. Haft JI, Kranz PD, Albert FJ, Fani K. Intravascular platelet aggregation in the heart induced by norepinephrine. Microscopic studies. Circulation 1972;46:698–708
4. Karmazyn M, Moffat MP, Beamish RE, Dhalla NS. Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenolinduced heart damage. J Pharmacol Exp Ther 1981;218:764–70
5. Kraikitpanitch S, Haygood CC, Baxter DJ, Yunice AA, Lindeman RD. Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs. Am Heart J 1976;92:615–22
6. Troskot B, Simicevic VN, Dodig M, Rotkvic I, Ivankovic D, Duvnjak M. The protective effect of zinc sulphate pretreatment against duodenal ulcers in the rat. Biometals 1997;10:325–9
7. Shih CJ, Chiou YL. Zinc sulfate inhibited inflammation of Der p2- induced airway smooth muscle cells by suppressing ERK1/2 and NFkappaB phosphorylation. Inflammation 2013;36:616–24
8. Chvapil M, Owen JA. Effect of zinc on acute and chronic isoproterenol induced heart injury. J Mol Cell Cardiol 1977;9:151–9
9. Powell SR. The antioxidant properties of zinc. J Nutr 2000;130:1447S–54S
10. Powell SR, Hall D, Aiuto L, Wapnir RA, Teichberg S, Tortolani AJ. Zinc improves postischemic recovery of isolated rat hearts through inhibition of oxidative stress. Am J Physiol 1994;266:H2497–507
11. Singla AK, Wadhwa H. Zinc-aspirin complex - synthesis, physicochemical and biological evaluation. Int J Pharm 1994;108:173–85
12. Rona G. Catecholamine cardiotoxicity. JMol Cell Cardiol 1985;17:291–306
13. Wexler BC. Myocardial infarction in young vs old male rats: pathophysiologic changes. Am Heart J 1978;96:70–80
14. Wexler BC, Greenberg BP. Effect of exercise on myocardial infarction in young vs. old male rats: electrocardiograph changes. Am Heart J 1974;88:343–50
15. Chagoya de Sanchez V, Hernandez-Munoz R, Lopez-Barrera F, Yanez L, Vidrio S, Suarez J, Cota-Garza MD, Aranda-Fraustro A, Cruz D. Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats: a long-term and integrative study. Can J Physiol Pharmacol 1997;75:1300–11
16. Korkmaz S, Radovits T, Barnucz E, Hirschberg K, Neugebauer P, Loganathan S, Veres G, Pali S, Seidel B, Zollner S, Karck M, Szabo G. Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury. Circulation 2009;120:677–86
17. Kmecova J, Klimas J. Heart rate correction of the QT duration in rats. Eur J Pharmacol 2010;641:187–92
18. Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA. Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. Nat Protoc 2008;3:1422–34
19. Wang T, Yu X, Qu S, Xu H, Han B, Sui D. Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. Eur J Pharmacol 2010;636:121–5
20. Zhou R, Xu Q, Zheng P, Yan L, Zheng J, Dai G. Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat. Eur J Pharmacol 2008;586:244–50
21. Suga H. Cardiac energetics: from E(max) to pressure-volume area. Clin Exp Pharmacol Physiol 2003;30:580–5
22. Sides GD. QT interval prolongation as a biomarker for torsades de pointes and sudden death in drug development. Dis Markers 2002;18:57–62
23. Luscher MS, Thygesen K, Ravkilde J, Heickendorff L. Applicability of cardiac troponin Tand I for early risk stratification in unstable coronary artery disease. TRIM Study Group. Thrombin inhibition in myocardial ischemia. Circulation 1997;96:2578–85
24. Ravkilde J, Nissen H, Horder M, Thygesen K. Independent prognostic value of serum creatine kinase isoenzyme MB mass, cardiac troponin T and myosin light chain levels in suspected acute myocardial infarction. Analysis of 28 months of follow-up in 196 patients. J Am Coll Cardiol 1995;25:574–81
25. Martynyuk RA, Semenova LA, Tsellarius YG. Effect of acetylsalicylic acid on development of infarct-like myocardial necroses induced in rats by a single injection of isoproterenol. Bull Exp Bio Med 1975;79:31–3
26. Ahn YK, Cho JG, Park WS, Kim NH, Kim JW, Kim SH, Cho JH, Park JH, Jeong MH, Park JC, Kang JC. The effects of antiplatelet agents in the prevention of ventricular tachyarrhythmias during acute myocardial ischemia in rats. Jpn Heart J 1999;40:79–86
27. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 2007;74:184–95
28. Frantz S, Hu K, Adamek A, Wolf J, Sallam A, Maier SK, Lonning S, Ling H, Ertl G, Bauersachs J. Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction. Basic Res Cardiol 2008;103:485–92
29. Chohan ZH, Iqbal MS, Iqbal HS, Scozzafava A, Supuran CT. Transition metal acetylsalicylates and their anti-inflammatory activity. J Enzyme Inhib Med Chem 2002;17:87–91
30. Radovits T, Gero D, Lin LN, Loganathan S, Hoppe-Tichy T, Szabo C, Karck M, Sakurai H, Szabo G. Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)- aspirinate complex. Rejuvenation Res 2008;11:945–56
31. Ott I, Kircher B, Bagowski CP, Vlecken DH, Ott EB, Will J, Bensdorf K, Sheldrick WS, Gust R.Modulation of the biological properties of aspirin by formation of a bioorganometallic derivative. Angew Chem Int Ed Engl 2009;48:1160–3
32. Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Toxicology 2007;230:178–88
33. Karthick M, Stanely Mainzen Prince P. Preventive effect of rutin, a bioflavonoid, on lipid peroxides and antioxidants in isoproterenolinduced myocardial infarction in rats. J Pharm Pharmacol 2006;58:701–7